CCD60_MOUSE
ID CCD60_MOUSE Reviewed; 545 AA.
AC Q8C4J0; B2RX39; Q6DIA4; Q6PAQ3;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Coiled-coil domain-containing protein 60;
GN Name=Ccdc60;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C4J0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C4J0-2; Sequence=VSP_019251, VSP_019252;
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DR EMBL; AK082047; BAC38398.1; -; mRNA.
DR EMBL; BC060151; AAH60151.1; -; mRNA.
DR EMBL; BC075662; AAH75662.1; -; mRNA.
DR EMBL; BC150892; AAI50893.1; -; mRNA.
DR CCDS; CCDS19599.1; -. [Q8C4J0-1]
DR RefSeq; NP_808427.1; NM_177759.3. [Q8C4J0-1]
DR AlphaFoldDB; Q8C4J0; -.
DR IntAct; Q8C4J0; 1.
DR STRING; 10090.ENSMUSP00000049912; -.
DR iPTMnet; Q8C4J0; -.
DR PhosphoSitePlus; Q8C4J0; -.
DR MaxQB; Q8C4J0; -.
DR PaxDb; Q8C4J0; -.
DR PRIDE; Q8C4J0; -.
DR ProteomicsDB; 281503; -. [Q8C4J0-1]
DR ProteomicsDB; 281504; -. [Q8C4J0-2]
DR Antibodypedia; 31402; 94 antibodies from 14 providers.
DR DNASU; 269693; -.
DR Ensembl; ENSMUST00000050178; ENSMUSP00000049912; ENSMUSG00000043913. [Q8C4J0-1]
DR GeneID; 269693; -.
DR KEGG; mmu:269693; -.
DR UCSC; uc008zey.1; mouse. [Q8C4J0-1]
DR CTD; 160777; -.
DR MGI; MGI:2141043; Ccdc60.
DR VEuPathDB; HostDB:ENSMUSG00000043913; -.
DR eggNOG; ENOG502QVFX; Eukaryota.
DR GeneTree; ENSGT00390000015428; -.
DR HOGENOM; CLU_036722_0_0_1; -.
DR InParanoid; Q8C4J0; -.
DR OMA; MQRKAPS; -.
DR OrthoDB; 1215093at2759; -.
DR PhylomeDB; Q8C4J0; -.
DR TreeFam; TF336372; -.
DR BioGRID-ORCS; 269693; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc60; mouse.
DR PRO; PR:Q8C4J0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8C4J0; protein.
DR Bgee; ENSMUSG00000043913; Expressed in spermatid and 59 other tissues.
DR ExpressionAtlas; Q8C4J0; baseline and differential.
DR InterPro; IPR031526; DUF4698.
DR PANTHER; PTHR34754; PTHR34754; 1.
DR Pfam; PF15769; DUF4698; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..545
FT /note="Coiled-coil domain-containing protein 60"
FT /id="PRO_0000239666"
FT REGION 224..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..99
FT /evidence="ECO:0000255"
FT COMPBIAS 234..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 188..207
FT /note="DPGGSKSTIKKINKDKSMGQ -> RKLIMQDPDWDENNDRPTL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019251"
FT VAR_SEQ 208..545
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019252"
SQ SEQUENCE 545 AA; 62969 MW; AC578617F52C4A84 CRC64;
MTKVPATKKL QKITSKKALW LFSSADQLTQ QASDKTAKNS KYIDKEIANL KKDLMRSRFL
IQCVKIGRGY FNILREENAM KKKQQLLQKL KEEELNKFQP AKKFSDIHCR DNLLATYDCE
KLKKLEAGII IRPFTPIHSC LMAPSLPESH VDPLFRQLCA LHWLLEALTI DHTHHTMRPL
IACWNPKDPG GSKSTIKKIN KDKSMGQRWD HFVTAPKTKK YKAPAIRTAM ASRKPSRRGS
TLSLTRTSGG SSPQSSMMSV NPGSDEPMGS KDIEDNESSS TKPEEEILHL YLQKLLEMVR
EDARRTILVE SEIQKKAPSI LSLVKQIKSE YGWKEWQTTH KSSERSSTTS AESHIQVIQK
KSKSRVNRDI IYCKTGVCSN MRAKFFSVAQ EAGFCLQDKM EILRKRQEER GLQKFHSFIV
TSNFQKDITK MRHQVSIVKG DAEEIADHWY FDLLSKLPED LKSFRPAKKI LMKLQKFGEN
LDLRIRPHVL LKVLQDLRIW ELCSPDIAVA IEFVREHIIH MPQEDYINWL QSRVNIPFRQ
RTILT
