CCD61_CHICK
ID CCD61_CHICK Reviewed; 403 AA.
AC Q5ZJ07;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Centrosomal protein CCDC61 {ECO:0000250|UniProtKB:Q9Y6R9};
DE AltName: Full=Coiled-coil domain-containing protein 61 {ECO:0000250|UniProtKB:Q9Y6R9};
DE AltName: Full=VFL3 homolog {ECO:0000250|UniProtKB:Q9Y6R9};
GN Name=CCDC61; Synonyms=VFL3 {ECO:0000250|UniProtKB:Q9Y6R9};
GN ORFNames=RCJMB04_22a5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Microtubule-binding centrosomal protein required for
CC centriole cohesion, independently of the centrosome-associated
CC protein/CEP250 and rootletin/CROCC linker. In interphase, required for
CC anchoring microtubule at the mother centriole subdistal appendages and
CC for centrosome positioning. During mitosis, may be involved in spindle
CC assembly and chromatin alignment by regulating the organization of
CC spindle microtubules into a symmetrical structure. Plays a non-
CC essential role in ciliogenesis. {ECO:0000250|UniProtKB:Q9Y6R9}.
CC -!- SUBUNIT: Forms homodimers (via head domain).
CC {ECO:0000250|UniProtKB:Q9Y6R9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9Y6R9}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriolar
CC satellite {ECO:0000250|UniProtKB:Q9Y6R9}. Cytoplasm, cytoskeleton,
CC cilium basal body {ECO:0000250|UniProtKB:Q9Y6R9}. Note=Localization at
CC the centriolar satellite is dependent on intact microtubule network.
CC Localizes at the centriole subdistal appendages and proximal ends.
CC Localized to centrosomal/satellite-like structures with the onset of
CC centrosome separation in early G2. {ECO:0000250|UniProtKB:Q9Y6R9}.
CC -!- DOMAIN: The coiled-coil domain is involved in microtubule-binding.
CC {ECO:0000250|UniProtKB:Q9Y6R9}.
CC -!- MISCELLANEOUS: The N-terminal 3D structure (head domain) resembles that
CC of NHEJ1/XLF, PAXX, SASS6 and XRCC4. {ECO:0000250|UniProtKB:Q9Y6R9}.
CC -!- SIMILARITY: Belongs to the CCDC61 family. {ECO:0000305}.
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DR EMBL; AJ720627; CAG32286.1; -; mRNA.
DR RefSeq; NP_001006546.1; NM_001006546.2.
DR RefSeq; XP_015132433.1; XM_015276947.1.
DR AlphaFoldDB; Q5ZJ07; -.
DR SMR; Q5ZJ07; -.
DR STRING; 9031.ENSGALP00000010847; -.
DR PaxDb; Q5ZJ07; -.
DR GeneID; 424880; -.
DR KEGG; gga:424880; -.
DR CTD; 729440; -.
DR VEuPathDB; HostDB:geneid_424880; -.
DR eggNOG; ENOG502QRAS; Eukaryota.
DR HOGENOM; CLU_038746_1_0_1; -.
DR InParanoid; Q5ZJ07; -.
DR OrthoDB; 1433381at2759; -.
DR PhylomeDB; Q5ZJ07; -.
DR TreeFam; TF329415; -.
DR PRO; PR:Q5ZJ07; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR GO; GO:0120103; C:centriolar subdistal appendage; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0098534; P:centriole assembly; ISS:UniProtKB.
DR GO; GO:0090307; P:mitotic spindle assembly; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..403
FT /note="Centrosomal protein CCDC61"
FT /id="PRO_0000311258"
FT REGION 1..142
FT /note="Head domain"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6R9"
FT REGION 224..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..178
FT /evidence="ECO:0000255"
FT COMPBIAS 275..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45322 MW; 8B89BE4009CA1682 CRC64;
MEEPRCLQAN CFFRGKEHSI QLSVSQAVLE VEVEERRSTK RWRGHFDAAS VEDLTRKTGN
FKQFGIFCSM LEAALMKSSE AVSLELLTYG DLEALRCCKV GVATRVPPST SPLSSKRYLI
LVYCVEFDRI HYPLPLPYIG EADMAALRRL VQEQQDELAQ LRDELRRAQQ EVWRLEDERL
RDKAWHQQEQ RRMTKELTEV KAAEKMLRAH VKTLTAELAV CRKGRSTSAT APGCPQDRRR
SNSRDSRSSS QGRLPPRSPS PAGSRPPRFN PTAFVRSREQ RRQEAELRRQ KLPRGTVSSG
DNCRRRGRRS SSAESLQSRR SAQSSGSEAD TCPQRRRGLG GPSTRSPLSA SSCNSTSVAS
HPNRGCKQHG KENLGTEPSA TLSEIDARLQ ALQAYISTLG THM
