CCD63_HUMAN
ID CCD63_HUMAN Reviewed; 563 AA.
AC Q8NA47; B4DY03; Q0P603; Q6P2E1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Coiled-coil domain-containing protein 63 {ECO:0000312|HGNC:HGNC:26669};
GN Name=CCDC63 {ECO:0000312|HGNC:HGNC:26669};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in spermiogenesis. Involved in the elongation of
CC flagella and the formation of sperm heads.
CC {ECO:0000250|UniProtKB:Q8CDV6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NA47-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NA47-2; Sequence=VSP_054895;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH44815.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK093162; BAC04081.1; -; mRNA.
DR EMBL; AK302207; BAG63565.1; -; mRNA.
DR EMBL; AC002351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC002375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044815; AAH44815.1; ALT_FRAME; mRNA.
DR EMBL; BC064580; AAH64580.1; -; mRNA.
DR EMBL; BC073147; AAH73147.1; -; mRNA.
DR CCDS; CCDS66470.1; -. [Q8NA47-2]
DR CCDS; CCDS9151.1; -. [Q8NA47-1]
DR RefSeq; NP_001273172.1; NM_001286243.1. [Q8NA47-2]
DR RefSeq; NP_001273173.1; NM_001286244.1.
DR RefSeq; NP_689804.1; NM_152591.2. [Q8NA47-1]
DR RefSeq; XP_006719325.1; XM_006719262.1. [Q8NA47-1]
DR RefSeq; XP_011536301.1; XM_011537999.1. [Q8NA47-1]
DR RefSeq; XP_011536303.1; XM_011538001.2. [Q8NA47-1]
DR AlphaFoldDB; Q8NA47; -.
DR SMR; Q8NA47; -.
DR BioGRID; 127765; 2.
DR IntAct; Q8NA47; 3.
DR STRING; 9606.ENSP00000312399; -.
DR iPTMnet; Q8NA47; -.
DR PhosphoSitePlus; Q8NA47; -.
DR BioMuta; CCDC63; -.
DR DMDM; 74729832; -.
DR EPD; Q8NA47; -.
DR MassIVE; Q8NA47; -.
DR PaxDb; Q8NA47; -.
DR PeptideAtlas; Q8NA47; -.
DR PRIDE; Q8NA47; -.
DR ProteomicsDB; 5484; -.
DR ProteomicsDB; 72636; -. [Q8NA47-1]
DR Antibodypedia; 45271; 129 antibodies from 18 providers.
DR DNASU; 160762; -.
DR Ensembl; ENST00000308208.10; ENSP00000312399.5; ENSG00000173093.13. [Q8NA47-1]
DR Ensembl; ENST00000545036.5; ENSP00000445881.1; ENSG00000173093.13. [Q8NA47-2]
DR GeneID; 160762; -.
DR KEGG; hsa:160762; -.
DR MANE-Select; ENST00000308208.10; ENSP00000312399.5; NM_152591.3; NP_689804.1.
DR UCSC; uc001trv.2; human. [Q8NA47-1]
DR CTD; 160762; -.
DR DisGeNET; 160762; -.
DR GeneCards; CCDC63; -.
DR HGNC; HGNC:26669; CCDC63.
DR HPA; ENSG00000173093; Tissue enriched (testis).
DR MIM; 617969; gene.
DR neXtProt; NX_Q8NA47; -.
DR OpenTargets; ENSG00000173093; -.
DR PharmGKB; PA143485415; -.
DR VEuPathDB; HostDB:ENSG00000173093; -.
DR eggNOG; ENOG502QSIU; Eukaryota.
DR GeneTree; ENSGT00940000153116; -.
DR InParanoid; Q8NA47; -.
DR OMA; QRCLLMQ; -.
DR OrthoDB; 648380at2759; -.
DR PhylomeDB; Q8NA47; -.
DR TreeFam; TF323742; -.
DR PathwayCommons; Q8NA47; -.
DR SignaLink; Q8NA47; -.
DR BioGRID-ORCS; 160762; 7 hits in 1064 CRISPR screens.
DR ChiTaRS; CCDC63; human.
DR GenomeRNAi; 160762; -.
DR Pharos; Q8NA47; Tbio.
DR PRO; PR:Q8NA47; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NA47; protein.
DR Bgee; ENSG00000173093; Expressed in left testis and 31 other tissues.
DR ExpressionAtlas; Q8NA47; baseline and differential.
DR Genevisible; Q8NA47; HS.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR GO; GO:0036158; P:outer dynein arm assembly; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR InterPro; IPR029652; CCDC63_fam.
DR PANTHER; PTHR21694:SF18; PTHR21694:SF18; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Differentiation; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..563
FT /note="Coiled-coil domain-containing protein 63"
FT /id="PRO_0000288874"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 18..201
FT /evidence="ECO:0000255"
FT COILED 233..291
FT /evidence="ECO:0000255"
FT COILED 341..422
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054895"
FT VARIANT 212
FT /note="L -> S (in dbSNP:rs12371434)"
FT /id="VAR_050758"
FT CONFLICT 35..60
FT /note="RQQFRKMVESRKSFKFRNQQKIASQY -> VGSAVAAAVGQAARAATDKQSG
FT PRHC (in Ref. 3; AAH64580)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 563 AA; 66250 MW; 55FF11018BB9B2DC CRC64;
MSVLKKNRRK DSDTPQEPSE KAKEQQAEAE LRKLRQQFRK MVESRKSFKF RNQQKIASQY
KEIKTLKTEQ DEITLLLSLM KSSRNMNRSE KNYMELRLLL QTKEDYEALI KSLKVLLAEL
DEKILQMEKK IANQKQIFAK MQEANNPRKL QKQIHILETR LNLVTVHFDK MLTTNAKLRK
EIEDLRFEKA AYDNVYQQLQ HCLLMEKKTM NLAIEQSSQA YEQRVEAMAR MAAMKDRQKK
DTSQYNLEIR ELERLYAHES KLKSFLLVKL NDRNEFEEQA KREEALKAKK HVKKNRGESF
ESYEVAHLRL LKLAESGNLN QLIEDFLAKE EKNFARFTYV TELNNDMEMM HKRTQRIQDE
IILLRSQQKL SHDDNHSVLR QLEDKLRKTT EEADMYESKY GEVSKTLDLL KNSVEKLFKK
INCDATKILV QLGETGKVTD INLPQYFAII EKKTNDLLLL ETYRRILEVE GAEAEIPPPF
INPFWGGSAL LKPPEPIKVI PPVLGADPFS DRLDDVEQPL DHSSLRQLVL DNYILKENRS
KEVRGDSLPE KVDDFRSRKK VTM
