CCD68_MOUSE
ID CCD68_MOUSE Reviewed; 333 AA.
AC Q8BVC4; Q80VD6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Coiled-coil domain-containing protein 68;
GN Name=Ccdc68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=28422092; DOI=10.1038/ncomms15057;
RA Huang N., Xia Y., Zhang D., Wang S., Bao Y., He R., Teng J., Chen J.;
RT "Hierarchical assembly of centriole subdistal appendages via centrosome
RT binding proteins CCDC120 and CCDC68.";
RL Nat. Commun. 8:15057-15057(2017).
CC -!- FUNCTION: Centriolar protein required for centriole subdistal appendage
CC assembly and microtubule anchoring in interphase cells
CC (PubMed:28422092). Together with CCDC120, cooperate with subdistal
CC appendage components ODF2, NIN and CEP170 for hierarchical subdistal
CC appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:28422092}.
CC -!- SUBUNIT: Interacts with CEP170. {ECO:0000250|UniProtKB:Q9H2F9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:Q9H2F9}.
CC Note=Localizes to the subdistal appendages of centrioles.
CC {ECO:0000250|UniProtKB:Q9H2F9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BVC4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BVC4-2; Sequence=VSP_021897;
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DR EMBL; AK078964; BAC37481.1; -; mRNA.
DR EMBL; BC046343; AAH46343.1; -; mRNA.
DR CCDS; CCDS29330.1; -. [Q8BVC4-1]
DR RefSeq; NP_958750.1; NM_201362.2. [Q8BVC4-1]
DR AlphaFoldDB; Q8BVC4; -.
DR SMR; Q8BVC4; -.
DR STRING; 10090.ENSMUSP00000046197; -.
DR iPTMnet; Q8BVC4; -.
DR PhosphoSitePlus; Q8BVC4; -.
DR MaxQB; Q8BVC4; -.
DR PaxDb; Q8BVC4; -.
DR PRIDE; Q8BVC4; -.
DR ProteomicsDB; 265592; -. [Q8BVC4-1]
DR ProteomicsDB; 265593; -. [Q8BVC4-2]
DR Antibodypedia; 53345; 95 antibodies from 21 providers.
DR DNASU; 381175; -.
DR Ensembl; ENSMUST00000043929; ENSMUSP00000046197; ENSMUSG00000038903. [Q8BVC4-1]
DR Ensembl; ENSMUST00000080050; ENSMUSP00000078959; ENSMUSG00000038903. [Q8BVC4-2]
DR GeneID; 381175; -.
DR KEGG; mmu:381175; -.
DR UCSC; uc008fnw.1; mouse. [Q8BVC4-1]
DR UCSC; uc008fnx.1; mouse. [Q8BVC4-2]
DR CTD; 80323; -.
DR MGI; MGI:3612676; Ccdc68.
DR VEuPathDB; HostDB:ENSMUSG00000038903; -.
DR eggNOG; ENOG502RXID; Eukaryota.
DR GeneTree; ENSGT00950000183065; -.
DR HOGENOM; CLU_071853_0_0_1; -.
DR InParanoid; Q8BVC4; -.
DR OMA; LRMEISV; -.
DR OrthoDB; 1010722at2759; -.
DR PhylomeDB; Q8BVC4; -.
DR TreeFam; TF331627; -.
DR BioGRID-ORCS; 381175; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ccdc68; mouse.
DR PRO; PR:Q8BVC4; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BVC4; protein.
DR Bgee; ENSMUSG00000038903; Expressed in otolith organ and 120 other tissues.
DR Genevisible; Q8BVC4; MM.
DR GO; GO:0120103; C:centriolar subdistal appendage; ISO:MGI.
DR GO; GO:0005814; C:centriole; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; ISO:MGI.
DR GO; GO:0008104; P:protein localization; ISO:MGI.
DR InterPro; IPR026735; Ccdc68.
DR PANTHER; PTHR23171:SF3; PTHR23171:SF3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..333
FT /note="Coiled-coil domain-containing protein 68"
FT /id="PRO_0000264612"
FT COILED 86..120
FT /evidence="ECO:0000255"
FT COILED 160..302
FT /evidence="ECO:0000255"
FT VAR_SEQ 199..289
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021897"
SQ SEQUENCE 333 AA; 37992 MW; AD17966A115FEE2F CRC64;
MTTVTVTTEV PSSGKTEDGH VFCDSSSAHI IEETEYVRQM RTTLEKIRNH MFKEKEGCGN
ARHKLDAEGS GNIQNGSDST TDPTCLDLLM ENMRRKDQQL LEMNRENEVL QIKLEASREA
GAAALRNVAQ RLFDNYQTQA GDLEKKHEGR KHLLQVNNLE KEQALKGSAE SLNLLSEKLE
EKHGQIVGLE NRVQRMENEK KTLLEKKLRL ESKLFQLKSN AANPKSCQDL QTEISILQEQ
ISHLQFVIHS QHQNLRSIIQ EMEGLKNTLK EQDTKIENLK EKVTVLEAQN KELKTRVAHW
TETPRTLVSK AVSTSELKTE GASPYLMLIR LRK
