ID   CCD69_BOVIN             Reviewed;         294 AA.
AC   A6QNP9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Coiled-coil domain-containing protein 69;
GN   Name=CCDC69;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a scaffold to regulate the recruitment and
CC       assembly of spindle midzone components. Required for the localization
CC       of AURKB and PLK1 to the spindle midzone.
CC       {ECO:0000250|UniProtKB:A6NI79}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:A6NI79}. Midbody {ECO:0000250|UniProtKB:A6NI79}.
CC       Note=During early anaphase, localizes along overlapping interpolar
CC       microtubules between the separating chromosomes. During late anaphase,
CC       localizes to the center of spindle midzone. Concentrated at the midbody
CC       during telophase. {ECO:0000250|UniProtKB:A6NI79}.
CC   -!- SIMILARITY: Belongs to the CCDC69 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI48946.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC148945; AAI48946.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001193553.1; NM_001206624.1.
DR   AlphaFoldDB; A6QNP9; -.
DR   SMR; A6QNP9; -.
DR   STRING; 9913.ENSBTAP00000040454; -.
DR   PaxDb; A6QNP9; -.
DR   PRIDE; A6QNP9; -.
DR   Ensembl; ENSBTAT00000042846; ENSBTAP00000040454; ENSBTAG00000002834.
DR   GeneID; 529878; -.
DR   KEGG; bta:529878; -.
DR   CTD; 26112; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002834; -.
DR   VGNC; VGNC:26911; CCDC69.
DR   eggNOG; ENOG502RYPP; Eukaryota.
DR   GeneTree; ENSGT00950000183026; -.
DR   InParanoid; A6QNP9; -.
DR   OMA; FEWQLRI; -.
DR   OrthoDB; 1278490at2759; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000002834; Expressed in omental fat pad and 103 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051233; C:spindle midzone; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051255; P:spindle midzone assembly; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Lipoprotein; Myristate;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..294
FT                   /note="Coiled-coil domain-containing protein 69"
FT                   /id="PRO_0000328961"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          47..270
FT                   /evidence="ECO:0000255"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TCJ8"
FT   MOD_RES         239
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A6NI79"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   294 AA;  34021 MW;  3B3C7D8B0F94FD46 CRC64;
     MGCGHSRLSC CKPPKKRRQR PDQPPKPEPQ ELGPLNGDTA TTDHVCASEE AEQHQKAITR
     ILQQHEEDKK KWAQQVEKER ELELGEKLNE QRKVLEGEHV EALRVLQASY EQDKEALTHS
     FQEAKAALQE TIDRLTAQIE AFQAKMKRAE ESILSRDYKK HIQEHGSLSQ FWEQELESLH
     FVIEMKNERI HELDKRLILM ETVKEKNLLL EEKITTLQQE NEDLHARGRN QMVVSRQLSE
     DLLLAREALE KESQSRRQLQ QEKEELLYRV LGADAAPAFP LASVTPTEVS FLAT