ID   CCD69_DANRE             Reviewed;         314 AA.
AC   A7MC22;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Coiled-coil domain-containing protein 69;
GN   Name=ccdc69;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a scaffold to regulate the recruitment and
CC       assembly of spindle midzone components. {ECO:0000250|UniProtKB:A6NI79}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:A6NI79}. Midbody {ECO:0000250|UniProtKB:A6NI79}.
CC       Note=During early anaphase, localizes along overlapping interpolar
CC       microtubules between the separating chromosomes. During late anaphase,
CC       localizes to the center of spindle midzone. Concentrated at the midbody
CC       during telophase. {ECO:0000250|UniProtKB:A6NI79}.
CC   -!- SIMILARITY: Belongs to the CCDC69 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI52014.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC152013; AAI52014.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A7MC22; -.
DR   SMR; A7MC22; -.
DR   PeptideAtlas; A7MC22; -.
DR   ZFIN; ZDB-GENE-120720-3; ccdc69.
DR   InParanoid; A7MC22; -.
DR   PRO; PR:A7MC22; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051233; C:spindle midzone; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051255; P:spindle midzone assembly; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Lipoprotein; Myristate;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..314
FT                   /note="Coiled-coil domain-containing protein 69"
FT                   /id="PRO_0000328964"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          106..291
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        16..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   314 AA;  36498 MW;  FC24B4EBF1B2F062 CRC64;
     MGCHNSKVCG QVSKKKKKNK AQEGEKRTKD IKLQDGRGTH SSEEERCCLE NQLENYEWQL
     KILHAVLTAS GDQEREQLLK DHPGDICTLV HSITEKVKTE ISADLNDLHE QQMRSVSEQH
     QSETEELQRL HSEEKNVLNE SHAAAEEALK DQIEDLTSEL KLFNELKRRA EASTLKRDLQ
     RNIETHGSPG EFWEQEQESL LFVIEMKRQN LQDQGNKLLQ MEAQVEKNLS LEDQLLQALQ
     QNEDFRVRIE NYQSLIQQLS KEQNDMQEVL EKQSLQNQKL IQEKEELLFK LLHRRDSCST
     FHLPSVIPTQ VSPS