CCD70_MOUSE
ID CCD70_MOUSE Reviewed; 223 AA.
AC Q9D9B0; Q9D9H6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 70;
GN Name=Ccdc70 {ECO:0000312|MGI:MGI:1915179};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK006920; BAB24790.1; -; mRNA.
DR EMBL; AK007190; BAB24892.1; -; mRNA.
DR EMBL; BC049553; AAH49553.1; -; mRNA.
DR CCDS; CCDS22167.1; -.
DR RefSeq; NP_080735.1; NM_026459.3.
DR RefSeq; XP_006509245.1; XM_006509182.1.
DR RefSeq; XP_006509246.1; XM_006509183.1.
DR AlphaFoldDB; Q9D9B0; -.
DR SMR; Q9D9B0; -.
DR STRING; 10090.ENSMUSP00000017193; -.
DR PhosphoSitePlus; Q9D9B0; -.
DR PaxDb; Q9D9B0; -.
DR PRIDE; Q9D9B0; -.
DR ProteomicsDB; 265596; -.
DR Antibodypedia; 42328; 66 antibodies from 18 providers.
DR Ensembl; ENSMUST00000017193; ENSMUSP00000017193; ENSMUSG00000017049.
DR Ensembl; ENSMUST00000070649; ENSMUSP00000069249; ENSMUSG00000017049.
DR GeneID; 67929; -.
DR KEGG; mmu:67929; -.
DR UCSC; uc009lci.1; mouse.
DR CTD; 83446; -.
DR MGI; MGI:1915179; Ccdc70.
DR VEuPathDB; HostDB:ENSMUSG00000017049; -.
DR eggNOG; ENOG502S3RY; Eukaryota.
DR GeneTree; ENSGT00940000153137; -.
DR HOGENOM; CLU_1293990_0_0_1; -.
DR InParanoid; Q9D9B0; -.
DR OMA; FREEMWN; -.
DR OrthoDB; 1426765at2759; -.
DR PhylomeDB; Q9D9B0; -.
DR TreeFam; TF336984; -.
DR BioGRID-ORCS; 67929; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D9B0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D9B0; protein.
DR Bgee; ENSMUSG00000017049; Expressed in seminiferous tubule of testis and 17 other tissues.
DR Genevisible; Q9D9B0; MM.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..223
FT /note="Coiled-coil domain-containing protein 70"
FT /id="PRO_0000234434"
FT REGION 199..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..153
FT /evidence="ECO:0000255"
FT COMPBIAS 203..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 11..13
FT /note="GLA -> DLP (in Ref. 1; BAB24790)"
FT /evidence="ECO:0000305"
FT CONFLICT 36..37
FT /note="EE -> GG (in Ref. 1; BAB24790)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="A -> G (in Ref. 1; BAB24790)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 223 AA; 27598 MW; 3568DE20D18F5D0D CRC64;
MFPFKVSKWM GLACLRSLVL PSPSIRQKKL IHKLQEEKAF REEMKIFHEK IEDFREEIWE
FRGKIRAFRG QILGFWEEER PFWEEEKIFW KEEKTFWEME KSFREEEKTF WKKYRTFWKE
DKAFWREDNA LWERDRNLLQ EDKALWEEEK ALWVEERALL AEEKALWEDK KSLWEEENAL
WEEEKALWVE GGGFHLLGEQ RHQNGPYNAN EEPQSTSFPR GRA
