CCD71_HUMAN
ID CCD71_HUMAN Reviewed; 467 AA.
AC Q8IV32; Q6IPE2; Q9H8H4; Q9H9F1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Coiled-coil domain-containing protein 71;
GN Name=CCDC71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-317 AND ARG-339.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-317 AND ARG-339.
RC TISSUE=Ovary, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK022862; BAB14278.1; -; mRNA.
DR EMBL; AK023691; BAB14642.1; ALT_INIT; mRNA.
DR EMBL; AC135506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035516; AAH35516.1; -; mRNA.
DR EMBL; BC071960; AAH71960.1; -; mRNA.
DR CCDS; CCDS2790.1; -.
DR RefSeq; NP_075054.3; NM_022903.3.
DR AlphaFoldDB; Q8IV32; -.
DR SMR; Q8IV32; -.
DR BioGRID; 122347; 37.
DR IntAct; Q8IV32; 6.
DR STRING; 9606.ENSP00000319006; -.
DR iPTMnet; Q8IV32; -.
DR PhosphoSitePlus; Q8IV32; -.
DR BioMuta; CCDC71; -.
DR DMDM; 317373459; -.
DR EPD; Q8IV32; -.
DR jPOST; Q8IV32; -.
DR MassIVE; Q8IV32; -.
DR MaxQB; Q8IV32; -.
DR PaxDb; Q8IV32; -.
DR PeptideAtlas; Q8IV32; -.
DR PRIDE; Q8IV32; -.
DR ProteomicsDB; 70646; -.
DR Antibodypedia; 56320; 68 antibodies from 15 providers.
DR DNASU; 64925; -.
DR Ensembl; ENST00000321895.7; ENSP00000319006.6; ENSG00000177352.10.
DR GeneID; 64925; -.
DR KEGG; hsa:64925; -.
DR MANE-Select; ENST00000321895.7; ENSP00000319006.6; NM_022903.4; NP_075054.3.
DR UCSC; uc003cwg.5; human.
DR CTD; 64925; -.
DR GeneCards; CCDC71; -.
DR HGNC; HGNC:25760; CCDC71.
DR HPA; ENSG00000177352; Low tissue specificity.
DR neXtProt; NX_Q8IV32; -.
DR OpenTargets; ENSG00000177352; -.
DR PharmGKB; PA143485422; -.
DR VEuPathDB; HostDB:ENSG00000177352; -.
DR eggNOG; ENOG502RY9H; Eukaryota.
DR GeneTree; ENSGT00940000155306; -.
DR HOGENOM; CLU_049410_1_0_1; -.
DR InParanoid; Q8IV32; -.
DR OMA; EWKDSST; -.
DR OrthoDB; 802843at2759; -.
DR PhylomeDB; Q8IV32; -.
DR TreeFam; TF336191; -.
DR PathwayCommons; Q8IV32; -.
DR SignaLink; Q8IV32; -.
DR BioGRID-ORCS; 64925; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; CCDC71; human.
DR GenomeRNAi; 64925; -.
DR Pharos; Q8IV32; Tdark.
DR PRO; PR:Q8IV32; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8IV32; protein.
DR Bgee; ENSG00000177352; Expressed in stromal cell of endometrium and 106 other tissues.
DR InterPro; IPR026695; Ccdc71/71L.
DR PANTHER; PTHR14484; PTHR14484; 1.
DR Pfam; PF15374; CCDC71L; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..467
FT /note="Coiled-coil domain-containing protein 71"
FT /id="PRO_0000234421"
FT REGION 81..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 279..359
FT /evidence="ECO:0000255"
FT COMPBIAS 81..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..376
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 317
FT /note="Q -> L (in dbSNP:rs4955419)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026236"
FT VARIANT 339
FT /note="W -> R (in dbSNP:rs4955418)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026237"
SQ SEQUENCE 467 AA; 49648 MW; 287B1BF4CF30B1A1 CRC64;
MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA FLQGLRDDGF
QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA SAPRTAMRLP AGRATLLPMP
LSGRLAKAST PALAKHATTN LLLSSLKQSS ASHARGAAVG FPTHLYPGVY PAMRLSVVLE
ALVPLKTPMP CLGAKHKAQS LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT
RKGPGAGPRR GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA
RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR AKAKVARTQP
RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP PKKRTRLGPR SPKAWLGPGT
AKLLKFRAIK VDRRSSDDEV RQRAQRILRV NLSPVIRLQP LLPYSAV
