CCD73_HUMAN
ID CCD73_HUMAN Reviewed; 1079 AA.
AC Q6ZRK6; Q6P5Q7; Q6ZMW0; Q86WE7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 73;
DE AltName: Full=Sarcoma antigen NY-SAR-79;
GN Name=CCDC73;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 361-621 (ISOFORM 1).
RX PubMed=12601173; DOI=10.1073/pnas.0437972100;
RA Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B.,
RA Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.;
RT "Immunomic analysis of human sarcoma.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZRK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZRK6-2; Sequence=VSP_024861, VSP_024862, VSP_024863;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH62749.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAO65175.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC87304.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD18615.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK128159; BAC87304.1; ALT_INIT; mRNA.
DR EMBL; AK131470; BAD18615.1; ALT_FRAME; mRNA.
DR EMBL; BC062749; AAH62749.1; ALT_INIT; mRNA.
DR EMBL; AY211922; AAO65175.1; ALT_SEQ; mRNA.
DR CCDS; CCDS41630.1; -. [Q6ZRK6-1]
DR RefSeq; NP_001008392.2; NM_001008391.3. [Q6ZRK6-1]
DR AlphaFoldDB; Q6ZRK6; -.
DR SMR; Q6ZRK6; -.
DR BioGRID; 138923; 2.
DR IntAct; Q6ZRK6; 1.
DR STRING; 9606.ENSP00000335325; -.
DR iPTMnet; Q6ZRK6; -.
DR PhosphoSitePlus; Q6ZRK6; -.
DR BioMuta; CCDC73; -.
DR DMDM; 146286064; -.
DR EPD; Q6ZRK6; -.
DR jPOST; Q6ZRK6; -.
DR MassIVE; Q6ZRK6; -.
DR MaxQB; Q6ZRK6; -.
DR PaxDb; Q6ZRK6; -.
DR PeptideAtlas; Q6ZRK6; -.
DR PRIDE; Q6ZRK6; -.
DR ProteomicsDB; 68144; -. [Q6ZRK6-1]
DR ProteomicsDB; 68145; -. [Q6ZRK6-2]
DR Antibodypedia; 49177; 18 antibodies from 8 providers.
DR DNASU; 493860; -.
DR Ensembl; ENST00000335185.10; ENSP00000335325.5; ENSG00000186714.13. [Q6ZRK6-1]
DR GeneID; 493860; -.
DR KEGG; hsa:493860; -.
DR MANE-Select; ENST00000335185.10; ENSP00000335325.5; NM_001008391.4; NP_001008392.2.
DR UCSC; uc001mtv.5; human. [Q6ZRK6-1]
DR CTD; 493860; -.
DR DisGeNET; 493860; -.
DR GeneCards; CCDC73; -.
DR HGNC; HGNC:23261; CCDC73.
DR HPA; ENSG00000186714; Tissue enriched (testis).
DR MIM; 612328; gene.
DR neXtProt; NX_Q6ZRK6; -.
DR OpenTargets; ENSG00000186714; -.
DR PharmGKB; PA143485424; -.
DR VEuPathDB; HostDB:ENSG00000186714; -.
DR eggNOG; ENOG502QQG1; Eukaryota.
DR GeneTree; ENSGT00390000013482; -.
DR HOGENOM; CLU_010526_0_0_1; -.
DR InParanoid; Q6ZRK6; -.
DR OMA; HSFHIKP; -.
DR OrthoDB; 137572at2759; -.
DR PhylomeDB; Q6ZRK6; -.
DR TreeFam; TF335743; -.
DR PathwayCommons; Q6ZRK6; -.
DR SignaLink; Q6ZRK6; -.
DR BioGRID-ORCS; 493860; 14 hits in 1062 CRISPR screens.
DR ChiTaRS; CCDC73; human.
DR GenomeRNAi; 493860; -.
DR Pharos; Q6ZRK6; Tdark.
DR PRO; PR:Q6ZRK6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6ZRK6; protein.
DR Bgee; ENSG00000186714; Expressed in testis and 91 other tissues.
DR ExpressionAtlas; Q6ZRK6; baseline and differential.
DR InterPro; IPR031650; CCDC73.
DR PANTHER; PTHR28660; PTHR28660; 1.
DR Pfam; PF15818; CCDC73; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1079
FT /note="Coiled-coil domain-containing protein 73"
FT /id="PRO_0000285294"
FT REGION 1052..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..210
FT /evidence="ECO:0000255"
FT COILED 236..384
FT /evidence="ECO:0000255"
FT COMPBIAS 1059..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 279..288
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024861"
FT VAR_SEQ 459..479
FT /note="DLQLFEKSFKNEIDTVVSQDE -> GNLKIILIFSNLYVDIYSKYF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024862"
FT VAR_SEQ 480..1079
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024863"
FT CONFLICT 374
FT /note="K -> E (in Ref. 1; BAD18615)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1079 AA; 124154 MW; 2EBE7434D7C7CB69 CRC64;
MESNFNTESS STFTLQSSSE TLFSIQLLDF KTSLLEALEE LRMRREAEIH YEEQIGKIIV
ETQELKWQKE TLQNQKETLA EQHKEAMAVF KKQLQMKMCA LEEEKGKYQL ATEIKEKEIE
GLKETLKALQ VSKYSLQKKV SEMEQKVQLH LLAKEDYHKQ LSEIEKYYAT ITGQFGLVKE
NHEKLEQNVR EAIQSNKRLS ALNKKQEAEI CSLKKELKKA ASDLIKSKVT CQYKMGEENI
NLTIKEQKFQ ELQERLNMEL ELNEKINEEI THIQEEKQDI IISFQHMQQL LRQQIQANTE
MEAELKVLKE NNQTLERDNE LQREKVKENE EKFLNLQNEH EKALGTWKRH AEELNGEINK
IKNELSSLKE THIKLQEHYN KLCNQKTFEE DKKFQNVPEV NNENSEMSTE KSENTIIQKY
NTEQEIREEN MENFCSDTEY REKEEKKEGS FIEEIIIDDL QLFEKSFKNE IDTVVSQDEN
QSEISLSKTL SLDKEVISQG QTSNVTDNRK SVTTEIKDKI CLEKDNGCTE FKSPNNHFVV
LDTAIETEKI HLERTRGLDV HHTDVNLEVE NNKTSFNSIL NETAHNTYHN NNKDVSENEP
FKQFRLLPGT REHALEKEIT NSDQTKADLD SSLDIKKNPV PCQKYSLRNS SNVMLDDKQC
KIKQIQLLTK KSECSILLSK QTSDFLQVCN DTLEKSELTV PCDIVIDHHV SYAAFSANSK
LLLKNSDKNV HSMSMLVKPN SSPGGKTMCK NMSDMQNSQF NNCLGYLENT NVNISHLHLN
NENSHASQAK DVKTAVHMKT CTETEFSNKK NQIDENQVTE ATKNDLFLFV SINERQHTLL
NNTEKTESLN DIVSGKMFSE GQLEESHSFH IEPSGDLVNR SGRSTFDLST SDKKTEKTPV
YMNFSDPGPW SKVNHIESQT ASSSTPCISL LLKERPLDPS ENKKIISMAL CKNIGVDDVG
KDIGPDTTSI NRVADTLNNW SIHPDPKGEP SEEKNAMAKT FYDSSFPTEH VKTKPLISTP
LQSHLQAIKT TKNTSGDDDW QSLITNQLNK SENLLSLEND NQPKKRKAEE TLEKNNRLK
