CCD73_MOUSE
ID CCD73_MOUSE Reviewed; 1066 AA.
AC Q8CDM4; A2A6Z9; Q501M4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Coiled-coil domain-containing protein 73;
GN Name=Ccdc73;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-661.
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 202-1066.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL606494; CAM17232.1; -; Genomic_DNA.
DR EMBL; BC095976; AAH95976.1; ALT_SEQ; mRNA.
DR EMBL; AK029862; BAC26648.1; ALT_INIT; mRNA.
DR CCDS; CCDS16494.2; -.
DR RefSeq; NP_808268.2; NM_177600.4.
DR AlphaFoldDB; Q8CDM4; -.
DR SMR; Q8CDM4; -.
DR BioGRID; 229274; 2.
DR STRING; 10090.ENSMUSP00000106743; -.
DR iPTMnet; Q8CDM4; -.
DR PhosphoSitePlus; Q8CDM4; -.
DR PaxDb; Q8CDM4; -.
DR PRIDE; Q8CDM4; -.
DR ProteomicsDB; 281316; -.
DR Antibodypedia; 49177; 18 antibodies from 8 providers.
DR DNASU; 211936; -.
DR Ensembl; ENSMUST00000111114; ENSMUSP00000106743; ENSMUSG00000045106.
DR GeneID; 211936; -.
DR KEGG; mmu:211936; -.
DR UCSC; uc008lkk.2; mouse.
DR CTD; 493860; -.
DR MGI; MGI:3606488; Ccdc73.
DR VEuPathDB; HostDB:ENSMUSG00000045106; -.
DR eggNOG; ENOG502QQG1; Eukaryota.
DR GeneTree; ENSGT00390000013482; -.
DR HOGENOM; CLU_010526_0_0_1; -.
DR InParanoid; Q8CDM4; -.
DR OMA; HSFHIKP; -.
DR OrthoDB; 137572at2759; -.
DR PhylomeDB; Q8CDM4; -.
DR TreeFam; TF335743; -.
DR BioGRID-ORCS; 211936; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ccdc73; mouse.
DR PRO; PR:Q8CDM4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CDM4; protein.
DR Bgee; ENSMUSG00000045106; Expressed in animal zygote and 74 other tissues.
DR ExpressionAtlas; Q8CDM4; baseline and differential.
DR Genevisible; Q8CDM4; MM.
DR InterPro; IPR031650; CCDC73.
DR PANTHER; PTHR28660; PTHR28660; 1.
DR Pfam; PF15818; CCDC73; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..1066
FT /note="Coiled-coil domain-containing protein 73"
FT /id="PRO_0000285295"
FT REGION 568..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..134
FT /evidence="ECO:0000255"
FT COILED 178..391
FT /evidence="ECO:0000255"
FT COMPBIAS 569..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 367
FT /note="S -> P (in Ref. 2; AAH95976)"
FT /evidence="ECO:0000305"
FT CONFLICT 615
FT /note="T -> A (in Ref. 2; AAH95976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1066 AA; 120389 MW; AF570EA3F7C641FE CRC64;
MEDSFNTTSS ASTFTLQSSS ETMVSIQLLD FRTSLLEALE ELRMRRKAET QYEEQIAKII
LETQELKWQK EALQNQKEAL IKQHKEAMGV LKNQLQMKMY ALEEEKGKYK LATEIKEKEI
EGLKETLKTL QVSQYSLQKK VSEMEQKAHL YHLAKEDYHK QLNEIEKYYA AITNQFGLVR
ENHVKLEQNV QEAIQLNKRL STLNEKQESE IHSLKKELKK AASELIKSKV TCQHKMEEES
IDLIIKEQKY EELQERLNME LEVNKKINEE ITHIQEEKQD IIISFQHMQQ LLQQETQANT
EIDAELKVLR ENNQTLERDN ELQREKVKEN EEKFLSLEKE HERALGTWKK HVEELSGEMN
VIKNELSSLR ETHAKLQEHY NKLCEQKKTE EYKKFQNVPE LNNENSDELT RKKSENIITQ
KYNSGPEIWG KNTKSFCLDT EYREEEKKDL PVGKTAEDLQ PFEISAKSEI NTMVSQDRNQ
SGMSPHRVLC LDKDATDQEQ TSDVTDSRKS VTVEVKDKLC LEKASGCSEF KSLNNFFLVV
DESLETEMVR LEGTEGLGLL HSGGDIPLDT RSNKASSNGM SNEMAHKRNY NTDGSESNPF
KQQSKLLPAD LENATEKEIT NQDQTKAGLD SFLDIKLNLD PCKKHGLQDS SHVTLDVKHQ
KIKQMVREES QCSTEPRSCY QLASKAPQKP GGTIACAAVV SPLGPSASSD NKLTALKKSE
NSINTLPTAA KPAPSPAERT TRTNTNDIQN SSLRNHLGAS ESSVSVSDFQ VNQGDSHTSQ
AKGLKTVVPL TTSSEKQPPS ESQITETPKS GLSSLVDVTG RQCMWLNNRD KTEALNGILS
GGTCHEGQLE EAHLSPATPS ADSVSTSARS AFDLPSPDKP EKTPGYIKFV PLSPWPKVNQ
TKTVGTATPS IPLFLKEKTV DLSGSRVITP VTFCKNVVLD DTRKNIESDP TSNSRAADTM
SNWSIHLDPK GQPREERNAT AQTVYDSSFP TEHVKAEPLI STVQQSHSQT VKVTDSPDPL
TFSPGNNDWQ SLVMNRLTEI EKLLSLESDN QPKRRKVEEM LDNIID
