CCD77_HUMAN
ID CCD77_HUMAN Reviewed; 488 AA.
AC Q9BR77; B4DDE8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Coiled-coil domain-containing protein 77;
GN Name=CCDC77;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-51, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BR77-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BR77-2; Sequence=VSP_043135;
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DR EMBL; AK027638; BAB55255.1; -; mRNA.
DR EMBL; AK293165; BAG56709.1; -; mRNA.
DR EMBL; AK316029; BAH14400.1; -; mRNA.
DR EMBL; AC005844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471116; EAW88967.1; -; Genomic_DNA.
DR EMBL; BC006444; AAH06444.1; -; mRNA.
DR CCDS; CCDS44781.1; -. [Q9BR77-2]
DR CCDS; CCDS8503.1; -. [Q9BR77-1]
DR RefSeq; NP_001123618.1; NM_001130146.1. [Q9BR77-2]
DR RefSeq; NP_001123619.1; NM_001130147.1. [Q9BR77-2]
DR RefSeq; NP_001123620.1; NM_001130148.1. [Q9BR77-2]
DR RefSeq; NP_115734.1; NM_032358.3. [Q9BR77-1]
DR AlphaFoldDB; Q9BR77; -.
DR SMR; Q9BR77; -.
DR BioGRID; 124044; 73.
DR IntAct; Q9BR77; 52.
DR MINT; Q9BR77; -.
DR STRING; 9606.ENSP00000239830; -.
DR iPTMnet; Q9BR77; -.
DR PhosphoSitePlus; Q9BR77; -.
DR BioMuta; CCDC77; -.
DR DMDM; 74732846; -.
DR EPD; Q9BR77; -.
DR jPOST; Q9BR77; -.
DR MassIVE; Q9BR77; -.
DR MaxQB; Q9BR77; -.
DR PaxDb; Q9BR77; -.
DR PeptideAtlas; Q9BR77; -.
DR PRIDE; Q9BR77; -.
DR ProteomicsDB; 78747; -. [Q9BR77-1]
DR ProteomicsDB; 78748; -. [Q9BR77-2]
DR Antibodypedia; 50661; 12 antibodies from 9 providers.
DR DNASU; 84318; -.
DR Ensembl; ENST00000239830.9; ENSP00000239830.4; ENSG00000120647.10. [Q9BR77-1]
DR Ensembl; ENST00000412006.6; ENSP00000412925.2; ENSG00000120647.10. [Q9BR77-2]
DR Ensembl; ENST00000422000.5; ENSP00000391870.1; ENSG00000120647.10. [Q9BR77-2]
DR Ensembl; ENST00000540180.5; ENSP00000440554.1; ENSG00000120647.10. [Q9BR77-2]
DR GeneID; 84318; -.
DR KEGG; hsa:84318; -.
DR MANE-Select; ENST00000239830.9; ENSP00000239830.4; NM_032358.4; NP_115734.1.
DR UCSC; uc001qig.4; human. [Q9BR77-1]
DR CTD; 84318; -.
DR DisGeNET; 84318; -.
DR GeneCards; CCDC77; -.
DR HGNC; HGNC:28203; CCDC77.
DR HPA; ENSG00000120647; Low tissue specificity.
DR neXtProt; NX_Q9BR77; -.
DR OpenTargets; ENSG00000120647; -.
DR PharmGKB; PA143485429; -.
DR VEuPathDB; HostDB:ENSG00000120647; -.
DR eggNOG; ENOG502QT8A; Eukaryota.
DR GeneTree; ENSGT00390000010251; -.
DR HOGENOM; CLU_035281_0_0_1; -.
DR InParanoid; Q9BR77; -.
DR OMA; HYQRDVQ; -.
DR OrthoDB; 1565693at2759; -.
DR PhylomeDB; Q9BR77; -.
DR TreeFam; TF329022; -.
DR PathwayCommons; Q9BR77; -.
DR SignaLink; Q9BR77; -.
DR BioGRID-ORCS; 84318; 28 hits in 1078 CRISPR screens.
DR ChiTaRS; CCDC77; human.
DR GenomeRNAi; 84318; -.
DR Pharos; Q9BR77; Tdark.
DR PRO; PR:Q9BR77; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9BR77; protein.
DR Bgee; ENSG00000120647; Expressed in oocyte and 125 other tissues.
DR ExpressionAtlas; Q9BR77; baseline and differential.
DR Genevisible; Q9BR77; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR InterPro; IPR037696; CCDC77.
DR PANTHER; PTHR22091; PTHR22091; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..488
FT /note="Coiled-coil domain-containing protein 77"
FT /id="PRO_0000271003"
FT REGION 21..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 55..118
FT /evidence="ECO:0000255"
FT COILED 208..488
FT /evidence="ECO:0000255"
FT COMPBIAS 194..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CZH8"
FT CROSSLNK 51
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043135"
FT VARIANT 25
FT /note="S -> R (in dbSNP:rs4980895)"
FT /id="VAR_029838"
FT VARIANT 335
FT /note="M -> T (in dbSNP:rs735295)"
FT /id="VAR_029839"
SQ SEQUENCE 488 AA; 57486 MW; 845D0113DA64889F CRC64;
MNFTPTHTPV CRKRTVVSKR GVAVSGPTKR RGMADSLEST PLPSPEDRLA KLHPSKELLE
YYQKKMAECE AENEDLLKKL ELYKEACEGQ HKLECDLQQR EEEIAELQKA LSDMQVCLFQ
EREHVLRLYS ENDRLRIREL EDKKKIQNLL ALVGTDAGEV TYFCKEPPHK VTILQKTIQA
VGECEQSESS AFKADPKISK RRPSRERKES SEHYQRDIQT LILQVEALQA QLGEQTKLSR
EQIEGLIEDR RIHLEEIQVQ HQRNQNKIKE LTKNLHHTQE LLYESTKDFL QLRSENQNKE
KSWMLEKDNL MSKIKQYRVQ CKKKEDKIGK VLPVMHESHH AQSEYIKSLK DKLVQEKKLS
NMYQEQCISL EEELARIREE EGMRREIFKD RTNKMGKRLQ IMTKRYEALE RRRILEVEGF
KTDIKVLRQK LKDLEQMLYK ATVNARANQD LALLCEVRDS NRRAHKIQGE LKNLKSKVFG
LENELRLC
