CCD77_MOUSE
ID CCD77_MOUSE Reviewed; 489 AA.
AC Q9CZH8; Q8VEJ7;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Coiled-coil domain-containing protein 77;
GN Name=Ccdc77;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CZH8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CZH8-2; Sequence=VSP_022264;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK012598; BAB28344.1; -; mRNA.
DR EMBL; BC018387; AAH18387.1; -; mRNA.
DR CCDS; CCDS20481.1; -. [Q9CZH8-1]
DR RefSeq; NP_080304.1; NM_026028.5. [Q9CZH8-1]
DR RefSeq; XP_006506553.1; XM_006506490.2. [Q9CZH8-1]
DR RefSeq; XP_006506554.1; XM_006506491.3. [Q9CZH8-1]
DR RefSeq; XP_006506555.1; XM_006506492.2.
DR RefSeq; XP_006506556.1; XM_006506493.3.
DR RefSeq; XP_006506557.1; XM_006506494.3. [Q9CZH8-2]
DR RefSeq; XP_006506558.1; XM_006506495.2. [Q9CZH8-2]
DR RefSeq; XP_006506559.1; XM_006506496.1.
DR RefSeq; XP_011239734.1; XM_011241432.2. [Q9CZH8-1]
DR RefSeq; XP_011239735.1; XM_011241433.2. [Q9CZH8-2]
DR AlphaFoldDB; Q9CZH8; -.
DR SMR; Q9CZH8; -.
DR BioGRID; 212011; 18.
DR IntAct; Q9CZH8; 18.
DR STRING; 10090.ENSMUSP00000032283; -.
DR iPTMnet; Q9CZH8; -.
DR PhosphoSitePlus; Q9CZH8; -.
DR EPD; Q9CZH8; -.
DR MaxQB; Q9CZH8; -.
DR PaxDb; Q9CZH8; -.
DR PeptideAtlas; Q9CZH8; -.
DR PRIDE; Q9CZH8; -.
DR ProteomicsDB; 265597; -. [Q9CZH8-1]
DR ProteomicsDB; 265598; -. [Q9CZH8-2]
DR Antibodypedia; 50661; 12 antibodies from 9 providers.
DR DNASU; 67200; -.
DR Ensembl; ENSMUST00000032283; ENSMUSP00000032283; ENSMUSG00000030177. [Q9CZH8-1]
DR Ensembl; ENSMUST00000112703; ENSMUSP00000108323; ENSMUSG00000030177. [Q9CZH8-2]
DR GeneID; 67200; -.
DR KEGG; mmu:67200; -.
DR UCSC; uc009dmz.2; mouse. [Q9CZH8-1]
DR UCSC; uc009dna.2; mouse. [Q9CZH8-2]
DR CTD; 84318; -.
DR MGI; MGI:1914450; Ccdc77.
DR VEuPathDB; HostDB:ENSMUSG00000030177; -.
DR eggNOG; ENOG502QT8A; Eukaryota.
DR GeneTree; ENSGT00390000010251; -.
DR HOGENOM; CLU_035281_0_0_1; -.
DR InParanoid; Q9CZH8; -.
DR OMA; HYQRDVQ; -.
DR OrthoDB; 1565693at2759; -.
DR PhylomeDB; Q9CZH8; -.
DR TreeFam; TF329022; -.
DR BioGRID-ORCS; 67200; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc77; mouse.
DR PRO; PR:Q9CZH8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CZH8; protein.
DR Bgee; ENSMUSG00000030177; Expressed in spermatocyte and 190 other tissues.
DR ExpressionAtlas; Q9CZH8; baseline and differential.
DR Genevisible; Q9CZH8; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR InterPro; IPR037696; CCDC77.
DR PANTHER; PTHR22091; PTHR22091; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..489
FT /note="Coiled-coil domain-containing protein 77"
FT /id="PRO_0000271004"
FT COILED 57..120
FT /evidence="ECO:0000255"
FT COILED 212..487
FT /evidence="ECO:0000255"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 14..31
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022264"
FT CONFLICT 172
FT /note="R -> K (in Ref. 2; AAH18387)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="M -> R (in Ref. 2; AAH18387)"
FT /evidence="ECO:0000305"
FT CONFLICT 341
FT /note="T -> A (in Ref. 2; AAH18387)"
FT /evidence="ECO:0000305"
FT CONFLICT 358
FT /note="K -> R (in Ref. 2; AAH18387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 57569 MW; 4206650430531681 CRC64;
MNFTPTRTPI CRKISFASKR GAGSGFGDTN RWKKMADSME STPLPSVEDR LAVLCPSQEL
LEYYQKKMAN CESENEDLLK KLELYREACE EQHKLEWNLQ QREEEIAELQ KALSDMQVCL
FQEREHVLRL YSENDRLRIR ELEDKKKIQN LLALVGPDAG EVTYFHKEPP HRVSILQKTL
QAAVACEPSA SKADPGVSKR QVRIKDKEGI SERHQRDTEM LLLQVEALQA QLGEQTKLSR
EQVEGLMEDR RIRVEEIQVQ HQRNQEKIME LTKSLHHTQE LLYESTKDFL QLKFENQNKE
KVWMLEKDHL MSKITQYRAQ CKKKEDKLGK VVPILHESHH TQNEYIKSLK DKLIQEKKLS
NMYQEQCISL EEELARIREE EGVRREIFKD RSNKMGKRLQ IMTKRYQALE HRRALEVEGF
KTDIKSLRQK LRDLEQMLYK ATMNNTHGDQ DLAMLCEVRD SNRRAHKIQG ELKNLKSKVF
GLENALRLC
