ID   CCD78_MOUSE             Reviewed;         437 AA.
AC   D3Z5T1;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Coiled-coil domain-containing protein 78;
GN   Name=Ccdc78;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Component of the deuterosome, a structure that promotes de
CC       novo centriole amplification in multiciliated cells that can generate
CC       more than 100 centrioles. Deuterosome-mediated centriole amplification
CC       occurs in terminally differentiated multiciliated cells (G1/0) and not
CC       in S phase. Essential for centriole amplification and is required for
CC       CEP152 localization to the deuterosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}.
CC       Sarcoplasmic reticulum {ECO:0000250}. Note=Localizes to centrioles and
CC       deuterosome. Found primarily in the perinuclear region as well as along
CC       the sarcolemmal membrane and in reticular pattern within the sarcoplasm
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCDC78 family. {ECO:0000305}.
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DR   EMBL; AC134908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50035.1; -.
DR   RefSeq; NP_001159401.1; NM_001165929.1.
DR   AlphaFoldDB; D3Z5T1; -.
DR   SMR; D3Z5T1; -.
DR   STRING; 10090.ENSMUSP00000093155; -.
DR   PhosphoSitePlus; D3Z5T1; -.
DR   EPD; D3Z5T1; -.
DR   MaxQB; D3Z5T1; -.
DR   PaxDb; D3Z5T1; -.
DR   PRIDE; D3Z5T1; -.
DR   ProteomicsDB; 265718; -.
DR   Antibodypedia; 22861; 25 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000095500; ENSMUSP00000093155; ENSMUSG00000071202.
DR   GeneID; 381077; -.
DR   KEGG; mmu:381077; -.
DR   UCSC; uc012ank.1; mouse.
DR   CTD; 124093; -.
DR   MGI; MGI:2685784; Ccdc78.
DR   VEuPathDB; HostDB:ENSMUSG00000071202; -.
DR   eggNOG; ENOG502R5JQ; Eukaryota.
DR   GeneTree; ENSGT00390000013678; -.
DR   HOGENOM; CLU_032909_0_0_1; -.
DR   InParanoid; D3Z5T1; -.
DR   OMA; GHSDDCR; -.
DR   OrthoDB; 773737at2759; -.
DR   PhylomeDB; D3Z5T1; -.
DR   TreeFam; TF336362; -.
DR   BioGRID-ORCS; 381077; 0 hits in 74 CRISPR screens.
DR   PRO; PR:D3Z5T1; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; D3Z5T1; protein.
DR   Bgee; ENSMUSG00000071202; Expressed in ovary and 42 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0098536; C:deuterosome; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042383; C:sarcolemma; ISS:UniProtKB.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0098535; P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:0003009; P:skeletal muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR039873; CCDC78.
DR   InterPro; IPR029329; DUF4472.
DR   PANTHER; PTHR22106; PTHR22106; 2.
DR   Pfam; PF14739; DUF4472; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome; Sarcoplasmic reticulum.
FT   CHAIN           1..437
FT                   /note="Coiled-coil domain-containing protein 78"
FT                   /id="PRO_0000415805"
FT   COILED          83..114
FT                   /evidence="ECO:0000255"
FT   COILED          147..287
FT                   /evidence="ECO:0000255"
FT   COILED          360..408
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   437 AA;  49472 MW;  FAD68A601FFCC216 CRC64;
     MDQRPELLSS MEYVASPDPK PGVPLRVAEN VAPGAEDWLP SASGHLAWAT SLETEHQTHL
     ELSEEQRLQI SKELVDLQIA THHLREQHEA EVFELRREIL RLESRVLELE LHGNGACQGH
     KVQPMANLGQ HQVPPLEPPG GQQKLQEELK WLLEHHRARQ QALETQVGVL SQQLQGAREE
     ARTTGQQLAS QAMVLASCKG QLRQAEAENT QLQLQLKKMN EEYAVRLQHY ARETVENASS
     TNQAALQAFL ESTLQDIRAA HRTREQQLAQ AARTYRKRLA DLNQRQELLL TTCRATFATA
     INLEPLPMHW ATELSHPREN EYGRHRTLLL YPEKGSGETS KENKSQPLAL DTASWAQIQQ
     RLQDFSQDTQ AELERERAQL MVRATMAEQQ LSELQEYVDQ HLGRYKQEIL KLRKLVNIGD
     PQGVEAVSSP GSGGARL