ID   CCD78_XENLA             Reviewed;         559 AA.
AC   Q66KE8;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Coiled-coil domain-containing protein 78;
DE   AltName: Full=xCCDC78;
GN   Name=ccdc78;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=24075808; DOI=10.1016/j.devcel.2013.08.021;
RA   Klos Dehring D.A., Vladar E.K., Werner M.E., Mitchell J.W., Hwang P.,
RA   Mitchell B.J.;
RT   "Deuterosome-mediated centriole biogenesis.";
RL   Dev. Cell 27:103-112(2013).
CC   -!- FUNCTION: Component of the deuterosome, a structure that promotes de
CC       novo centriole amplification in multiciliated cells that can generate
CC       more than 100 centrioles. Deuterosome-mediated centriole amplification
CC       occurs in terminally differentiated multiciliated cells (G1/0) and not
CC       in S phase. Essential for centriole amplification and is required for
CC       cep152 localization to the deuterosome. {ECO:0000269|PubMed:24075808}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000269|PubMed:24075808}.
CC       Note=Localizes to centrioles and deuterosome.
CC   -!- TISSUE SPECIFICITY: Restricted to multiciliated cells.
CC       {ECO:0000269|PubMed:24075808}.
CC   -!- INDUCTION: Highly up-regulated in the ciliated epithelia of embryonic
CC       skin during the developmental window of centriole biogenesis.
CC       Expression is probably activated by mcidas/mcin.
CC       {ECO:0000269|PubMed:24075808}.
CC   -!- SIMILARITY: Belongs to the CCDC78 family. {ECO:0000305}.
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DR   EMBL; BC080433; AAH80433.1; -; mRNA.
DR   RefSeq; NP_001087605.1; NM_001094136.1.
DR   AlphaFoldDB; Q66KE8; -.
DR   SMR; Q66KE8; -.
DR   DNASU; 447429; -.
DR   GeneID; 447429; -.
DR   KEGG; xla:447429; -.
DR   CTD; 447429; -.
DR   Xenbase; XB-GENE-5895378; ccdc78.S.
DR   OrthoDB; 773737at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 447429; Expressed in brain and 9 other tissues.
DR   GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0098536; C:deuterosome; IDA:UniProtKB.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0098535; P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; IDA:UniProtKB.
DR   InterPro; IPR039873; CCDC78.
DR   InterPro; IPR029329; DUF4472.
DR   PANTHER; PTHR22106; PTHR22106; 1.
DR   Pfam; PF14739; DUF4472; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..559
FT                   /note="Coiled-coil domain-containing protein 78"
FT                   /id="PRO_0000424819"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          9..327
FT                   /evidence="ECO:0000255"
FT   COILED          419..541
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  65184 MW;  6E2662AF000A086D CRC64;
     MDSTEDRETP LKDQIRRLTN ENVQLQDRNE RLYAKLGELQ DKMGKLAGSK TDLSSKLVLS
     EEEKLKISKE LIELQIETNK IREHYEAETF ELKNTILTLE NRLMSLELQK EKLAGEHESV
     KERLQAVDAN RKELADEYIV LKSNYLALSK EHEKEVAKND ELSMELLNLA SRRGQDETYS
     QSRALVNEAT AELDRVKAMV NRLSARNIKP EDLVATEYER QKLERNLLGN QDHIREEIEN
     MKKIHETQQQ RLEERIIAMG KELQEAKRAI RNTQHKMAEQ SAVLLTSQSQ LQETEAQNSH
     LQLQLKELNE EYRSRLNRYI QDLADYVDGT ARSKGDGTRM KHFVDNMLSD IKASHRSREE
     QLAGAARQYK KRMQNLIKKH QSLLIAYRMQ REQLLASGNQ DVEPGPPEHH FTITDPELQS
     QVGLELNRLR EDKARLETQI HDLKEKKRLS DAGTSNQHVE HGGKLQEESW AEIRKQLREF
     THNTQEELER ERSQLLSRAL VAEEQVAELQ DYVDKHLARY KQEILRLRKL LGNEEQRAVS
     ADAPQSLLIR ALRRNSHEM