CCD7_ORYSJ
ID CCD7_ORYSJ Reviewed; 609 AA.
AC Q7XU29; A0A0P0WDK3;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Carotenoid cleavage dioxygenase 7, chloroplastic;
DE Short=OsCCD7;
DE AltName: Full=Beta,beta-carotene 9',10'-oxygenase;
DE EC=1.13.11.68;
DE AltName: Full=Protein DWARF-17;
DE AltName: Full=Protein HIGH-TILLERING DWARF 1;
DE AltName: Full=Protein MAX3 homolog;
DE Flags: Precursor;
GN Name=CCD7; Synonyms=D17, HTD1;
GN OrderedLocusNames=Os04g0550600, LOC_Os04g46470;
GN ORFNames=OsJ_15694, OSJNBb0034G17.9;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Shiokari;
RX PubMed=15659436; DOI=10.1093/pcp/pci022;
RA Ishikawa S., Maekawa M., Arite T., Onishi K., Takamure I., Kyozuka J.;
RT "Suppression of tiller bud activity in tillering dwarf mutants of rice.";
RL Plant Cell Physiol. 46:79-86(2005).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY AUXIN, AND DISRUPTION PHENOTYPE.
RX PubMed=17092317; DOI=10.1111/j.1365-313x.2006.02916.x;
RA Zou J., Zhang S., Zhang W., Li G., Chen Z., Zhai W., Zhao X., Pan X.,
RA Xie Q., Zhu L.;
RT "The rice HIGH-TILLERING DWARF1 encoding an ortholog of Arabidopsis MAX3 is
RT required for negative regulation of the outgrowth of axillary buds.";
RL Plant J. 48:687-698(2006).
RN [9]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Shiokari;
RX PubMed=17655651; DOI=10.1111/j.1365-313x.2007.03210.x;
RA Arite T., Iwata H., Ohshima K., Maekawa M., Nakajima M., Kojima M.,
RA Sakakibara H., Kyozuka J.;
RT "DWARF10, an RMS1/MAX4/DAD1 ortholog, controls lateral bud outgrowth in
RT rice.";
RL Plant J. 51:1019-1029(2007).
RN [10]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Shiokari;
RX PubMed=18690207; DOI=10.1038/nature07272;
RA Umehara M., Hanada A., Yoshida S., Akiyama K., Arite T., Takeda-Kamiya N.,
RA Magome H., Kamiya Y., Shirasu K., Yoneyama K., Kyozuka J., Yamaguchi S.;
RT "Inhibition of shoot branching by new terpenoid plant hormones.";
RL Nature 455:195-200(2008).
RN [11]
RP CATALYTIC ACTIVITY.
RX PubMed=22422982; DOI=10.1126/science.1218094;
RA Alder A., Jamil M., Marzorati M., Bruno M., Vermathen M., Bigler P.,
RA Ghisla S., Bouwmeester H., Beyer P., Al-Babili S.;
RT "The path from beta-carotene to carlactone, a strigolactone-like plant
RT hormone.";
RL Science 335:1348-1351(2012).
RN [12]
RP DISRUPTION PHENOTYPE.
RX PubMed=23204501; DOI=10.1093/mp/sss138;
RA Fukui K., Ito S., Asami T.;
RT "Selective mimics of strigolactone actions and their potential use for
RT controlling damage caused by root parasitic weeds.";
RL Mol. Plant 6:88-99(2013).
CC -!- FUNCTION: Involved in strigolactones biosynthesis by cleaving
CC asymmetrically a variety of linear and cyclic carotenoids at the 9-10
CC double bond. Produces one C(13) beta-ionone and the C(27) 10'-apo-beta-
CC carotenal. Strigolactones are hormones that inhibit tillering and shoot
CC branching through the MAX-dependent pathway, contribute to the
CC regulation of shoot architectural response to phosphate-limiting
CC conditions and function as rhizosphere signal that stimulates hyphal
CC branching of arbuscular mycorrhizal fungi and trigger seed germination
CC of root parasitic weeds. Can rescue the phenotype in the Arabidopsis
CC max3 mutant. {ECO:0000269|PubMed:17092317}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal +
CC beta-ionone; Xref=Rhea:RHEA:34399, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32325, ChEBI:CHEBI:67188, ChEBI:CHEBI:67192;
CC EC=1.13.11.68; Evidence={ECO:0000269|PubMed:22422982};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular bundles of roots, leaves,
CC stems and panicles. {ECO:0000269|PubMed:17092317}.
CC -!- INDUCTION: By auxin. {ECO:0000269|PubMed:17092317}.
CC -!- DISRUPTION PHENOTYPE: Dwarf phenotype with increased branching and
CC tiller number, and strong reduction of the root levels of
CC strigolactones. {ECO:0000269|PubMed:15659436,
CC ECO:0000269|PubMed:17092317, ECO:0000269|PubMed:17655651,
CC ECO:0000269|PubMed:18690207, ECO:0000269|PubMed:23204501}.
CC -!- MISCELLANEOUS: The branching phenotypes of the ccd7/max3 and ccd8b/max4
CC mutants can be rescued by exogenous treatment with the synthetic
CC strigolactone analogs GR24 and 4BD. {ECO:0000305|PubMed:23204501}.
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family. {ECO:0000305}.
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DR EMBL; AL663000; CAD41601.3; -; Genomic_DNA.
DR EMBL; AP008210; BAF15405.1; -; Genomic_DNA.
DR EMBL; AP014960; BAS90374.1; -; Genomic_DNA.
DR EMBL; CM000141; EAZ31551.1; -; Genomic_DNA.
DR EMBL; AK109771; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015637185.1; XM_015781699.1.
DR AlphaFoldDB; Q7XU29; -.
DR SMR; Q7XU29; -.
DR STRING; 4530.OS04T0550600-01; -.
DR PaxDb; Q7XU29; -.
DR PRIDE; Q7XU29; -.
DR EnsemblPlants; Os04t0550600-01; Os04t0550600-01; Os04g0550600.
DR GeneID; 4336591; -.
DR Gramene; Os04t0550600-01; Os04t0550600-01; Os04g0550600.
DR KEGG; osa:4336591; -.
DR eggNOG; KOG1285; Eukaryota.
DR HOGENOM; CLU_016472_6_1_1; -.
DR InParanoid; Q7XU29; -.
DR OMA; EGGQPYE; -.
DR OrthoDB; 524712at2759; -.
DR PlantReactome; R-OSA-5367729; Strigolactone biosynthesis.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000007752; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR Genevisible; Q7XU29; OS.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0102395; F:9-cis-beta-carotene 9',10'-cleavage oxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0045549; F:9-cis-epoxycarotenoid dioxygenase activity; IBA:GO_Central.
DR GO; GO:0010436; F:carotenoid dioxygenase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IDA:UniProtKB.
DR GO; GO:0016121; P:carotene catabolic process; IDA:UniProtKB.
DR GO; GO:0009733; P:response to auxin; IMP:Gramene.
DR GO; GO:0010223; P:secondary shoot formation; IMP:Gramene.
DR GO; GO:1901601; P:strigolactone biosynthetic process; IDA:UniProtKB.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; PTHR10543; 1.
DR Pfam; PF03055; RPE65; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Plastid;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..34
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 35..609
FT /note="Carotenoid cleavage dioxygenase 7, chloroplastic"
FT /id="PRO_0000422058"
FT BINDING 263
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 316
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 394
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 603
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT CONFLICT 571
FT /note="H -> R (in Ref. 6; AK109771)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 609 AA; 68188 MW; 3DD6E61067EB7B4D CRC64;
MATQAIAPMH AAVVHRHHVL PPRRCVRRRG VFVRASAAAA AAAAETDTLS AAFWDYNLLF
RSQRDECLDS IPLRVTEGAI PPDFPAGTYY LAGPGIFSDD HGSTVHPLDG HGYLRSFRFR
PGDRTIHYSA RFVETAAKRE ESRDGASWRF THRGPFSVLQ GGKKVGNVKV MKNVANTSVL
RWGGRLLCLW EGGQPYEVDP RTLETVGPFD LLGLAAADDN KATNASAARR PWLQEAGLDA
AARLLRPVLS GVFDMPGKRL LAHYKIDPRR GRLLMVACNA EDMLLPRSHF TFYEFDAHFD
LVQKREFVVP DHLMIHDWAF TDTHYILLGN RIKLDIPGSL LALTGTHPMI AALAVDPRRQ
STPVYLLPRS PETEAGGRDW SVPIEAPSQM WSVHVGNAFE EANRRGGLDV RLHMSSCSYQ
WFHFHRMFGY NWHHKKLDPS FMNAAKGKEW LPRLVQVAIE LDRTGECRRC SVRRLSDQHA
RPADFPAINP SYANQRNRFV YAGAASGSRR FLPYFPFDSV VKVDVSDGSA RWWSTDGRKF
VGEPVFVPTG GGEDGGYVLL VEYAVSKHRC HLVVLDAKKI GTENALVAKL EVPKNLTFPM
GFHGFWGDE
