CCD81_HUMAN
ID CCD81_HUMAN Reviewed; 652 AA.
AC Q6ZN84; A0AVL7; Q53FW3; Q9H5E5;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Coiled-coil domain-containing protein 81;
GN Name=CCDC81;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lung;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=25074808; DOI=10.1242/jcs.157008;
RA Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT "Proteomic analysis of mammalian sperm cells identifies new components of
RT the centrosome.";
RL J. Cell Sci. 127:4128-4133(2014).
CC -!- INTERACTION:
CC Q6ZN84; Q6UWF3: SCIMP; NbExp=5; IntAct=EBI-14404745, EBI-2872510;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:25074808}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZN84-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZN84-2; Sequence=VSP_025806;
CC Name=3;
CC IsoId=Q6ZN84-3; Sequence=VSP_025805, VSP_025807;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD96888.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK027167; BAB15681.1; -; mRNA.
DR EMBL; AK131331; BAD18491.1; -; mRNA.
DR EMBL; AK223168; BAD96888.1; ALT_INIT; mRNA.
DR EMBL; BC126412; AAI26413.1; -; mRNA.
DR CCDS; CCDS53691.1; -. [Q6ZN84-1]
DR CCDS; CCDS8276.1; -. [Q6ZN84-2]
DR RefSeq; NP_001149946.1; NM_001156474.1. [Q6ZN84-1]
DR RefSeq; NP_068599.3; NM_021827.4. [Q6ZN84-2]
DR AlphaFoldDB; Q6ZN84; -.
DR SMR; Q6ZN84; -.
DR IntAct; Q6ZN84; 5.
DR STRING; 9606.ENSP00000415528; -.
DR GlyGen; Q6ZN84; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZN84; -.
DR PhosphoSitePlus; Q6ZN84; -.
DR SwissPalm; Q6ZN84; -.
DR BioMuta; CCDC81; -.
DR DMDM; 148841312; -.
DR MassIVE; Q6ZN84; -.
DR PaxDb; Q6ZN84; -.
DR PeptideAtlas; Q6ZN84; -.
DR PRIDE; Q6ZN84; -.
DR ProteomicsDB; 67993; -. [Q6ZN84-1]
DR ProteomicsDB; 67994; -. [Q6ZN84-2]
DR ProteomicsDB; 67995; -. [Q6ZN84-3]
DR Antibodypedia; 50011; 105 antibodies from 19 providers.
DR DNASU; 60494; -.
DR Ensembl; ENST00000354755.5; ENSP00000346800.1; ENSG00000149201.10. [Q6ZN84-2]
DR Ensembl; ENST00000445632.7; ENSP00000415528.2; ENSG00000149201.10. [Q6ZN84-1]
DR Ensembl; ENST00000528728.1; ENSP00000437165.1; ENSG00000149201.10. [Q6ZN84-3]
DR GeneID; 60494; -.
DR KEGG; hsa:60494; -.
DR MANE-Select; ENST00000445632.7; ENSP00000415528.2; NM_001156474.2; NP_001149946.1.
DR UCSC; uc001pbw.3; human. [Q6ZN84-1]
DR CTD; 60494; -.
DR DisGeNET; 60494; -.
DR GeneCards; CCDC81; -.
DR HGNC; HGNC:26281; CCDC81.
DR HPA; ENSG00000149201; Tissue enhanced (choroid plexus, fallopian tube).
DR neXtProt; NX_Q6ZN84; -.
DR OpenTargets; ENSG00000149201; -.
DR PharmGKB; PA128394704; -.
DR VEuPathDB; HostDB:ENSG00000149201; -.
DR eggNOG; ENOG502QT76; Eukaryota.
DR GeneTree; ENSGT00390000011985; -.
DR HOGENOM; CLU_020603_0_0_1; -.
DR InParanoid; Q6ZN84; -.
DR OMA; ETNIWKD; -.
DR OrthoDB; 759717at2759; -.
DR PhylomeDB; Q6ZN84; -.
DR TreeFam; TF336185; -.
DR PathwayCommons; Q6ZN84; -.
DR SignaLink; Q6ZN84; -.
DR BioGRID-ORCS; 60494; 6 hits in 1070 CRISPR screens.
DR ChiTaRS; CCDC81; human.
DR GenomeRNAi; 60494; -.
DR Pharos; Q6ZN84; Tdark.
DR PRO; PR:Q6ZN84; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6ZN84; protein.
DR Bgee; ENSG00000149201; Expressed in right uterine tube and 104 other tissues.
DR ExpressionAtlas; Q6ZN84; baseline and differential.
DR Genevisible; Q6ZN84; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR040673; CCDC81_HU_dom_2.
DR InterPro; IPR026295; Coiled-coil_dom_cont_p_81.
DR InterPro; IPR028034; HU-CCDC81.
DR PANTHER; PTHR14362; PTHR14362; 1.
DR Pfam; PF14908; HU-CCDC81_euk_1; 1.
DR Pfam; PF18289; HU-CCDC81_euk_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..652
FT /note="Coiled-coil domain-containing protein 81"
FT /id="PRO_0000288877"
FT REGION 238..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 436..493
FT /evidence="ECO:0000255"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 417
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT VAR_SEQ 1..217
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_025805"
FT VAR_SEQ 96..185
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_025806"
FT VAR_SEQ 324..371
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_025807"
FT VARIANT 449
FT /note="Y -> C (in dbSNP:rs3741005)"
FT /id="VAR_032524"
FT CONFLICT 83
FT /note="E -> G (in Ref. 1; BAD18491)"
FT /evidence="ECO:0000305"
FT CONFLICT 407
FT /note="K -> I (in Ref. 1; BAB15681)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 652 AA; 76084 MW; BE258DA8038343AE CRC64;
MLDTIARALQ DLGRQVLPTL PSLSQEEVSI IWGNVSEFVR RQLTLHKGVQ IPAFGTFTFI
RQKLEVGNNK FILIQRPVFI MVEKLVQIHG LKQNKVYTPG EIPIVPLNFV MISLEGPFNR
DVVEGCVKET LLFLSRSISM KQNVEFTFKG IGVLMIRDSK VKMRFYKDFL CTMDGSGALA
KALANRPGTV DSVLSSREAL RKWPSSVLAF PRIELKEMEN KLPMETLVEE CGENRERKCK
LKDQSDKEEG TRDISSPKRL RDRQALFPAK VTNVSLLEKF ERSESGGKIM TPESLSYPSC
LKHDSEMKPQ TSPACQDHNK AGQEMCYVCL QRAQRNSLLY YSEERRREIE DERLIQQYQM
LKDQEALFRH QMKSLATREQ NQKNAAYNLG VAEAIRNHKN EKPEFYKSFL FDKRPLSPAL
NALKQEEYSR SLLKQMDNRQ ENEIKQRQYR ELMDRLEQVQ LTEELAAQRA KFLKDKMEET
QCYKRALDAQ IKNKPSRLPP FEPDSSEPIF GKNEGELMVE KQKREQNYMK HQLEAAANHK
RKAILHQLVD QRRDLQMLQR TQREHLADRT AELERVNRVN QCLQEDWERS AAMKKQRDLE
DKAFERASDK LFLLDQCEKY RRCKQCQRRT SNVGESNLWP LNKFLPGSRL LV
