CCD81_MOUSE
ID CCD81_MOUSE Reviewed; 654 AA.
AC Q9D5W4; A1L0U4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Coiled-coil domain-containing protein 81;
GN Name=Ccdc81;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q6ZN84}.
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DR EMBL; AK014876; BAB29597.1; -; mRNA.
DR EMBL; BC127049; AAI27050.1; -; mRNA.
DR CCDS; CCDS52306.1; -.
DR RefSeq; NP_001156451.1; NM_001162979.1.
DR AlphaFoldDB; Q9D5W4; -.
DR SMR; Q9D5W4; -.
DR BioGRID; 214318; 1.
DR STRING; 10090.ENSMUSP00000044087; -.
DR iPTMnet; Q9D5W4; -.
DR PhosphoSitePlus; Q9D5W4; -.
DR MaxQB; Q9D5W4; -.
DR PaxDb; Q9D5W4; -.
DR PRIDE; Q9D5W4; -.
DR ProteomicsDB; 265599; -.
DR Antibodypedia; 50011; 105 antibodies from 19 providers.
DR Ensembl; ENSMUST00000041195; ENSMUSP00000044087; ENSMUSG00000039391.
DR GeneID; 70884; -.
DR KEGG; mmu:70884; -.
DR UCSC; uc009igf.2; mouse.
DR CTD; 60494; -.
DR MGI; MGI:1918134; Ccdc81.
DR VEuPathDB; HostDB:ENSMUSG00000039391; -.
DR eggNOG; ENOG502QT76; Eukaryota.
DR GeneTree; ENSGT00390000011985; -.
DR HOGENOM; CLU_020603_0_0_1; -.
DR InParanoid; Q9D5W4; -.
DR OMA; ETNIWKD; -.
DR OrthoDB; 759717at2759; -.
DR PhylomeDB; Q9D5W4; -.
DR TreeFam; TF336185; -.
DR BioGRID-ORCS; 70884; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9D5W4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D5W4; protein.
DR Bgee; ENSMUSG00000039391; Expressed in spermatid and 44 other tissues.
DR ExpressionAtlas; Q9D5W4; baseline and differential.
DR Genevisible; Q9D5W4; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR040673; CCDC81_HU_dom_2.
DR InterPro; IPR026295; Coiled-coil_dom_cont_p_81.
DR InterPro; IPR028034; HU-CCDC81.
DR PANTHER; PTHR14362; PTHR14362; 1.
DR Pfam; PF14908; HU-CCDC81_euk_1; 1.
DR Pfam; PF18289; HU-CCDC81_euk_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..654
FT /note="Coiled-coil domain-containing protein 81"
FT /id="PRO_0000288878"
FT REGION 196..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..562
FT /evidence="ECO:0000255"
FT COMPBIAS 208..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN9"
SQ SEQUENCE 654 AA; 75826 MW; 8161BB8965EFA835 CRC64;
MLDRVGPGFQ DLCRQVLPTL PTLSQEEVST IWANVSDFVE RQLTMHKGVQ ISGLGTFTFS
RQQLEVGNKK FVLVQRPVFI MAEKLVQTHG LKQNKVFSPG DIPVVPLNFV MISLEGPFNR
DTIEGCVKET LLFLSRSISV KQKVEFTFKG IGVLSIRDSK VKMRFYKDFL CSMDGSGILT
KALANRPGTM DSVLSSRESY RKRPNSAMAF PRIEHKETEN KTPVEVVGEE GGENRPRKIK
LKDQSDKEGG AREISSPKKH RERQSISPAK VTSVSLLDKF ERSGNGGKIT ACENLSSPGC
QRNDNERPRT SPAPACQDHN KAGQEMCYVC LQRAQRNFAL HYGDERRRRE IEDERLMQQY
QILKDQEAFF KNQVKGMAAR EQNQKNAAYN LGVAEAIRNH KNEKPEFYKS FLFDKRPLSP
EINAFKQEEY SQSLLKQMES KREKEIKQRQ NRELMDRLEQ VQLTEELAAQ RAQYLKEKME
ETQHYKRALD AQVKNKPPQL PMFEPDSAEP IFGKNDGERE MEKRKREQSC MKHQMEAAAS
HKRNTILNQL VDQRRDLQML QRTQREHMAD RAAEMDRVNR LNQCLQEDWD RSLAMKKQRD
VEEKAFERAS DKLFLLDQCE KYRRCRQCQR RTCNTGESNL WPMNKFLQGS RLLV
