CCD82_HUMAN
ID CCD82_HUMAN Reviewed; 544 AA.
AC Q8N4S0; B3KPU7; Q8WV71; Q9H2Q5; Q9H5E3;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Coiled-coil domain-containing protein 82;
GN Name=CCDC82; ORFNames=HT025;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-327.
RC TISSUE=Lung, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP GLU-149 AND ARG-327.
RC TISSUE=Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-154, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-154, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-154 AND THR-227, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88; SER-131; SER-154;
RP SER-219; THR-227 AND SER-329, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4S0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4S0-2; Sequence=VSP_035403, VSP_035404;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15683.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF245436; AAG44484.1; -; mRNA.
DR EMBL; AK027171; BAB15683.1; ALT_FRAME; mRNA.
DR EMBL; AK056790; BAG51809.1; -; mRNA.
DR EMBL; BC018663; AAH18663.1; -; mRNA.
DR EMBL; BC033726; AAH33726.1; -; mRNA.
DR CCDS; CCDS8307.1; -. [Q8N4S0-1]
DR CCDS; CCDS86241.1; -. [Q8N4S0-2]
DR RefSeq; NP_001305665.1; NM_001318736.1. [Q8N4S0-1]
DR RefSeq; NP_001305666.1; NM_001318737.1. [Q8N4S0-2]
DR RefSeq; NP_079001.2; NM_024725.3. [Q8N4S0-1]
DR RefSeq; XP_005274349.1; XM_005274292.3. [Q8N4S0-1]
DR RefSeq; XP_011541286.1; XM_011542984.2. [Q8N4S0-1]
DR RefSeq; XP_011541289.1; XM_011542987.2. [Q8N4S0-1]
DR RefSeq; XP_011541290.1; XM_011542988.2. [Q8N4S0-1]
DR RefSeq; XP_016873794.1; XM_017018305.1.
DR RefSeq; XP_016873795.1; XM_017018306.1.
DR RefSeq; XP_016873796.1; XM_017018307.1. [Q8N4S0-1]
DR RefSeq; XP_016873797.1; XM_017018308.1.
DR AlphaFoldDB; Q8N4S0; -.
DR BioGRID; 122880; 23.
DR IntAct; Q8N4S0; 19.
DR STRING; 9606.ENSP00000278520; -.
DR iPTMnet; Q8N4S0; -.
DR MetOSite; Q8N4S0; -.
DR PhosphoSitePlus; Q8N4S0; -.
DR BioMuta; CCDC82; -.
DR DMDM; 97046260; -.
DR EPD; Q8N4S0; -.
DR jPOST; Q8N4S0; -.
DR MassIVE; Q8N4S0; -.
DR MaxQB; Q8N4S0; -.
DR PaxDb; Q8N4S0; -.
DR PeptideAtlas; Q8N4S0; -.
DR PRIDE; Q8N4S0; -.
DR ProteomicsDB; 71960; -. [Q8N4S0-1]
DR ProteomicsDB; 71961; -. [Q8N4S0-2]
DR Antibodypedia; 31692; 88 antibodies from 15 providers.
DR DNASU; 79780; -.
DR Ensembl; ENST00000278520.9; ENSP00000278520.5; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000423339.2; ENSP00000397156.2; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000530106.2; ENSP00000495640.1; ENSG00000149231.16. [Q8N4S0-2]
DR Ensembl; ENST00000530203.2; ENSP00000431148.2; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000644686.1; ENSP00000495081.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000645366.1; ENSP00000494629.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000645439.1; ENSP00000495063.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000645500.1; ENSP00000495485.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000646638.1; ENSP00000494657.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000646818.2; ENSP00000496393.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000679708.1; ENSP00000506371.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000679788.1; ENSP00000505510.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000679856.1; ENSP00000505833.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000679960.1; ENSP00000506164.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000680171.1; ENSP00000505858.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000680763.1; ENSP00000504912.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000680979.1; ENSP00000505977.1; ENSG00000149231.16. [Q8N4S0-1]
DR Ensembl; ENST00000681164.1; ENSP00000506296.1; ENSG00000149231.16. [Q8N4S0-1]
DR GeneID; 79780; -.
DR KEGG; hsa:79780; -.
DR MANE-Select; ENST00000646818.2; ENSP00000496393.1; NM_024725.4; NP_079001.2.
DR UCSC; uc009ywp.4; human. [Q8N4S0-1]
DR CTD; 79780; -.
DR DisGeNET; 79780; -.
DR GeneCards; CCDC82; -.
DR HGNC; HGNC:26282; CCDC82.
DR HPA; ENSG00000149231; Low tissue specificity.
DR MalaCards; CCDC82; -.
DR neXtProt; NX_Q8N4S0; -.
DR OpenTargets; ENSG00000149231; -.
DR PharmGKB; PA143485431; -.
DR VEuPathDB; HostDB:ENSG00000149231; -.
DR eggNOG; KOG4805; Eukaryota.
DR GeneTree; ENSGT00390000004986; -.
DR HOGENOM; CLU_037130_0_0_1; -.
DR InParanoid; Q8N4S0; -.
DR OMA; HYVHFKR; -.
DR PhylomeDB; Q8N4S0; -.
DR TreeFam; TF328837; -.
DR PathwayCommons; Q8N4S0; -.
DR SignaLink; Q8N4S0; -.
DR BioGRID-ORCS; 79780; 28 hits in 1078 CRISPR screens.
DR ChiTaRS; CCDC82; human.
DR GenomeRNAi; 79780; -.
DR Pharos; Q8N4S0; Tdark.
DR PRO; PR:Q8N4S0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N4S0; protein.
DR Bgee; ENSG00000149231; Expressed in calcaneal tendon and 180 other tissues.
DR ExpressionAtlas; Q8N4S0; baseline and differential.
DR Genevisible; Q8N4S0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR025244; CCDC82.
DR InterPro; IPR025451; DUF4211.
DR Pfam; PF13846; DUF4196; 2.
DR Pfam; PF13926; DUF4211; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..544
FT /note="Coiled-coil domain-containing protein 82"
FT /id="PRO_0000234288"
FT REGION 1..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 229..256
FT /evidence="ECO:0000255"
FT COMPBIAS 12..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..294
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 131
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 154
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66H73"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 227
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 331..344
FT /note="YSFSDHYTHFERVV -> CKFNIKKMFHELFS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035403"
FT VAR_SEQ 345..544
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035404"
FT VARIANT 128
FT /note="K -> R (in dbSNP:rs3748261)"
FT /id="VAR_050764"
FT VARIANT 149
FT /note="Q -> E (in dbSNP:rs17851661)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026164"
FT VARIANT 327
FT /note="Q -> R (in dbSNP:rs10831519)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026165"
SQ SEQUENCE 544 AA; 64002 MW; 472518C7D444638B CRC64;
MIHVRRHETR RNSKSHVPEQ KSRVDWRRTK RSSISQLLDS DEELDSEEFD SDEELDSDES
FENDEELDSN KGPDCNKTPG SERELNLSKI QSEGNDSKCL INSGNGSTYE EETNKIKHRN
IDLQDQEKHL SQEDNDLNKQ TGQIIEDDQE KHLSQEDNDL NKQTGQIIED DLEEEDIKRG
KRKRLSSVMC DSDESDDSDI LVRKVGVKRP RRVVEDEGSS VEMEQKTPEK TLAAQKREKL
QKLKELSKQR SRQRRSSGRD FEDSEKESCP SSDEVDEEEE EDNYESDEDG DDYIIDDFVV
QDEEGDEENK NQQGEKLTTS QLKLVKQNSL YSFSDHYTHF ERVVKALLIN ALDESFLGTL
YDGTRQKSYA KDMLTSLHYL DNRFVQPRLE SLVSRSRWKE QYKERVENYS NVSIHLKNPE
NCSCQACGLH RYCKYSVHLS GELYNTRTMQ IDNFMSHDKQ VFTVGRICAS RTRIYHKLKH
FKFKLYQECC TIAMTEEVED EQVKETVERI FRRSKENGWI KEKYGQLEEY LNFADYFQEE
KFEL
