CCD83_MOUSE
ID CCD83_MOUSE Reviewed; 305 AA.
AC Q9D4V3; Q8CEQ7; Q9D4W3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Coiled-coil domain-containing protein 83;
GN Name=Ccdc83;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D4V3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D4V3-2; Sequence=VSP_025813, VSP_025814;
CC Name=3;
CC IsoId=Q9D4V3-3; Sequence=VSP_025812;
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DR EMBL; AK016080; BAB30106.1; -; mRNA.
DR EMBL; AK016114; BAB30120.1; -; mRNA.
DR EMBL; AK016535; BAC25488.1; -; mRNA.
DR EMBL; BC120723; AAI20724.1; -; mRNA.
DR EMBL; BC120721; AAI20722.1; -; mRNA.
DR CCDS; CCDS21446.1; -. [Q9D4V3-1]
DR RefSeq; NP_083532.1; NM_029256.3. [Q9D4V3-1]
DR RefSeq; NP_899116.1; NM_183293.1.
DR AlphaFoldDB; Q9D4V3; -.
DR SMR; Q9D4V3; -.
DR STRING; 10090.ENSMUSP00000047758; -.
DR iPTMnet; Q9D4V3; -.
DR PhosphoSitePlus; Q9D4V3; -.
DR PaxDb; Q9D4V3; -.
DR PRIDE; Q9D4V3; -.
DR ProteomicsDB; 281505; -. [Q9D4V3-1]
DR ProteomicsDB; 281506; -. [Q9D4V3-2]
DR ProteomicsDB; 281507; -. [Q9D4V3-3]
DR Antibodypedia; 31411; 155 antibodies from 22 providers.
DR DNASU; 75338; -.
DR Ensembl; ENSMUST00000040413; ENSMUSP00000047758; ENSMUSG00000030617. [Q9D4V3-1]
DR GeneID; 75338; -.
DR KEGG; mmu:75338; -.
DR UCSC; uc009igy.1; mouse. [Q9D4V3-1]
DR CTD; 220047; -.
DR MGI; MGI:1918255; Ccdc83.
DR VEuPathDB; HostDB:ENSMUSG00000030617; -.
DR eggNOG; ENOG502QS0V; Eukaryota.
DR GeneTree; ENSGT00390000013087; -.
DR InParanoid; Q9D4V3; -.
DR OrthoDB; 987774at2759; -.
DR PhylomeDB; Q9D4V3; -.
DR TreeFam; TF329512; -.
DR BioGRID-ORCS; 75338; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc83; mouse.
DR PRO; PR:Q9D4V3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D4V3; protein.
DR Bgee; ENSMUSG00000030617; Expressed in seminiferous tubule of testis and 21 other tissues.
DR ExpressionAtlas; Q9D4V3; baseline and differential.
DR Genevisible; Q9D4V3; MM.
DR InterPro; IPR026702; CCDC83.
DR PANTHER; PTHR21468; PTHR21468; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..305
FT /note="Coiled-coil domain-containing protein 83"
FT /id="PRO_0000288883"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 37..186
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 133..305
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025812"
FT VAR_SEQ 217..220
FT /note="ENDW -> KMTG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025813"
FT VAR_SEQ 221..305
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025814"
FT CONFLICT 21
FT /note="K -> Q (in Ref. 1; BAC25488)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> T (in Ref. 1; BAC25488)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="E -> G (in Ref. 1; BAB30106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 35642 MW; 56E81BA749CE109E CRC64;
MDSSAKGSKK DAPDGPPKDS KLPVSEALLD YHREIKENAV ERFMFHIKKL REKNQKYQER
NRRLKEEQNW HIKNLIKELK EKNLDEAPIV TREEVEEAMK EKWEFERQQE ASLKEMRIQI
NEAEKLFLEK LSEKEYWEEY KNVGSAQHAQ LIVSLQNDID TVKENAEKMS EQYKVTLEDE
KKRISRETMI QLKQRKEWAT QHAVRFIDKN NYREIWENDW LKKEGDTASF GNVLSLLDFL
PPDLHTAEPC VSSGQSRGSL RILAPFALQL WSKLSGLLPT LVTPDPVCII WSFGPGQTNS
MAICP
