CCD86_RAT
ID CCD86_RAT Reviewed; 341 AA.
AC Q5XIB5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Coiled-coil domain-containing protein 86;
DE AltName: Full=Cytokine-induced protein with coiled-coil domain;
GN Name=Ccdc86; Synonyms=Cyclon;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17300783; DOI=10.1016/j.febslet.2007.01.083;
RA Hoshino A., Fujii H.;
RT "Redundant promoter elements mediate IL-3-induced expression of a novel
RT cytokine-inducible gene, cyclon.";
RL FEBS Lett. 581:975-980(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND SER-124, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000250}.
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DR EMBL; DQ501253; ABF68614.1; -; mRNA.
DR EMBL; BC083770; AAH83770.1; -; mRNA.
DR RefSeq; NP_001006975.1; NM_001006974.2.
DR AlphaFoldDB; Q5XIB5; -.
DR SMR; Q5XIB5; -.
DR STRING; 10116.ENSRNOP00000028405; -.
DR iPTMnet; Q5XIB5; -.
DR PhosphoSitePlus; Q5XIB5; -.
DR jPOST; Q5XIB5; -.
DR PaxDb; Q5XIB5; -.
DR PRIDE; Q5XIB5; -.
DR GeneID; 293738; -.
DR KEGG; rno:293738; -.
DR UCSC; RGD:1359280; rat.
DR CTD; 79080; -.
DR RGD; 1359280; Ccdc86.
DR VEuPathDB; HostDB:ENSRNOG00000020925; -.
DR eggNOG; KOG4538; Eukaryota.
DR HOGENOM; CLU_065828_0_0_1; -.
DR InParanoid; Q5XIB5; -.
DR OMA; FSQMLQD; -.
DR OrthoDB; 1470010at2759; -.
DR PhylomeDB; Q5XIB5; -.
DR TreeFam; TF325663; -.
DR PRO; PR:Q5XIB5; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020925; Expressed in ovary and 20 other tissues.
DR Genevisible; Q5XIB5; RN.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR InterPro; IPR026570; CCDC86.
DR InterPro; IPR005579; Cgr1-like.
DR PANTHER; PTHR13557; PTHR13557; 1.
DR Pfam; PF03879; Cgr1; 1.
PE 1: Evidence at protein level;
KW Citrullination; Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..341
FT /note="Coiled-coil domain-containing protein 86"
FT /id="PRO_0000286095"
FT REGION 1..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 261..304
FT /evidence="ECO:0000255"
FT COMPBIAS 25..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 66
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 70
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 103
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6F5"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 142
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ89"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ89"
FT MOD_RES 170
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ89"
FT MOD_RES 200
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ89"
FT MOD_RES 323
FT /note="Citrulline"
FT /evidence="ECO:0000250"
SQ SEQUENCE 341 AA; 38585 MW; 7ECF8C9CC5607477 CRC64;
MGTPLRRSRR LEGLNPLSLE NLPDPEVSRA KRALVDFKSN PEETRELESP RVPPLDLVSP
QPQPETSPES PCPKQDAGFG SPQRQPEPHP GSLQLHQDLG LDSPAGQTES NPESPQREQS
SKLSPTQDSE VAHAKEEVIP RSPEPCPGQQ APGPEPSQPA QELAFQAPSS PERQLEPSKL
PPAGESVTGS LDLKKRVIAS PQAPASKKLK EELPVIPKGK PKSGRVWKDR SKKRFSQMVQ
DKPLRTSWQR KMKERQERKL AKDFARHLEE EKQRRRQEKK ERRAENLRRR LENERKAEIV
QVIRNPAKLK KAKKKQLRSI QKRDTLALLQ KQPPQRPVAK V
