CCD87_HUMAN
ID CCD87_HUMAN Reviewed; 849 AA.
AC Q9NVE4; Q8NE76;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Coiled-coil domain-containing protein 87;
GN Name=CCDC87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-217.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in spermatogenesis, where it is important for
CC normal sperm head morphology. Also required for the acrosome reaction
CC and thus normal male fertility. {ECO:0000250|UniProtKB:Q8CDL9}.
CC -!- INTERACTION:
CC Q9NVE4; Q01850: CDR2; NbExp=3; IntAct=EBI-749261, EBI-1181367;
CC Q9NVE4; Q08379: GOLGA2; NbExp=6; IntAct=EBI-749261, EBI-618309;
CC Q9NVE4; P19012: KRT15; NbExp=3; IntAct=EBI-749261, EBI-739566;
CC Q9NVE4; P14373: TRIM27; NbExp=3; IntAct=EBI-749261, EBI-719493;
CC Q9NVE4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-749261, EBI-2130429;
CC Q9NVE4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-749261, EBI-739895;
CC -!- SIMILARITY: Belongs to the CCDC87 family. {ECO:0000305}.
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DR EMBL; AK001648; BAA91808.1; -; mRNA.
DR EMBL; AP001157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034469; AAH34469.1; -; mRNA.
DR CCDS; CCDS8145.1; -.
DR RefSeq; NP_060689.2; NM_018219.2.
DR AlphaFoldDB; Q9NVE4; -.
DR BioGRID; 120526; 18.
DR IntAct; Q9NVE4; 13.
DR STRING; 9606.ENSP00000328487; -.
DR GlyGen; Q9NVE4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NVE4; -.
DR PhosphoSitePlus; Q9NVE4; -.
DR BioMuta; CCDC87; -.
DR DMDM; 296434428; -.
DR MassIVE; Q9NVE4; -.
DR PaxDb; Q9NVE4; -.
DR PeptideAtlas; Q9NVE4; -.
DR PRIDE; Q9NVE4; -.
DR ProteomicsDB; 82784; -.
DR Antibodypedia; 44485; 101 antibodies from 15 providers.
DR DNASU; 55231; -.
DR Ensembl; ENST00000333861.5; ENSP00000328487.3; ENSG00000182791.5.
DR GeneID; 55231; -.
DR KEGG; hsa:55231; -.
DR MANE-Select; ENST00000333861.5; ENSP00000328487.3; NM_018219.3; NP_060689.2.
DR UCSC; uc001oiq.5; human.
DR CTD; 55231; -.
DR GeneCards; CCDC87; -.
DR HGNC; HGNC:25579; CCDC87.
DR HPA; ENSG00000182791; Tissue enriched (testis).
DR neXtProt; NX_Q9NVE4; -.
DR OpenTargets; ENSG00000182791; -.
DR PharmGKB; PA144596455; -.
DR VEuPathDB; HostDB:ENSG00000182791; -.
DR eggNOG; ENOG502QQN1; Eukaryota.
DR GeneTree; ENSGT00390000018647; -.
DR HOGENOM; CLU_016540_0_0_1; -.
DR InParanoid; Q9NVE4; -.
DR OMA; WEKWSNK; -.
DR OrthoDB; 365617at2759; -.
DR PhylomeDB; Q9NVE4; -.
DR TreeFam; TF353429; -.
DR PathwayCommons; Q9NVE4; -.
DR SignaLink; Q9NVE4; -.
DR BioGRID-ORCS; 55231; 11 hits in 1067 CRISPR screens.
DR GenomeRNAi; 55231; -.
DR Pharos; Q9NVE4; Tdark.
DR PRO; PR:Q9NVE4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NVE4; protein.
DR Bgee; ENSG00000182791; Expressed in left testis and 73 other tissues.
DR Genevisible; Q9NVE4; HS.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; ISS:UniProtKB.
DR GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR037383; CCDC87.
DR PANTHER; PTHR16078; PTHR16078; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Differentiation; Fertilization; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..849
FT /note="Coiled-coil domain-containing protein 87"
FT /id="PRO_0000295145"
FT COILED 387..415
FT /evidence="ECO:0000255"
FT VARIANT 156
FT /note="A -> T (in dbSNP:rs1110707)"
FT /id="VAR_056782"
FT VARIANT 217
FT /note="F -> L (in dbSNP:rs17853294)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033224"
FT CONFLICT 738
FT /note="L -> R (in Ref. 1; BAA91808)"
FT /evidence="ECO:0000305"
FT CONFLICT 834
FT /note="K -> R (in Ref. 1; BAA91808)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 849 AA; 96402 MW; 6FFEAD6E56B6BCD8 CRC64;
MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL AKLTVASLCS
QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA ELSLSHKNNQ KLRKRLEAYV
LLSSEQLFLR YLHLLVTMST PRGVFTESAT LTRLAASLAR DCTLFLTSPN VYRGLLADFQ
ALLRAEQASG DVDKLHPVCP AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL
NEPGRMDPVK ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG LIVAEDLKQL
IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK MLRNLQEEEA SGQWDPQPPK
SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD RNFLDSFHIE GAGALYNHLA GELDPKAIEK
MDIDNFVGST TREVYKELMS HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI
INPELVGLYS QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP GEWDWNTVLE
HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD MTIKYSSKAR LRQLPSLVNA
WERALKPIQL REALLARLEW FEGQASNPNR FFKKTNLSSS HFLEENQVRS HLHRKLNLME
SSLVSLLEEI ELIFGEPVIF KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST
LFRSSAASL
