CCD89_HUMAN
ID CCD89_HUMAN Reviewed; 374 AA.
AC Q8N998;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Coiled-coil domain-containing protein 89;
DE AltName: Full=Bc8 orange-interacting protein;
GN Name=CCDC89; Synonyms=BOIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neonatal skin;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14648848; DOI=10.1002/dvdy.10406;
RA Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S.,
RA Gessler M., Christophe D., Bellefroid E.J.;
RT "Identification of BOIP, a novel cDNA highly expressed during
RT spermatogenesis that encodes a protein interacting with the orange domain
RT of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.";
RL Dev. Dyn. 228:716-725(2003).
CC -!- SUBUNIT: Interacts with HEY1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N998; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-12814117, EBI-742802;
CC Q8N998; Q96CN5: LRRC45; NbExp=3; IntAct=EBI-12814117, EBI-2805176;
CC Q8N998; Q92569: PIK3R3; NbExp=3; IntAct=EBI-12814117, EBI-79893;
CC Q8N998; P43897: TSFM; NbExp=3; IntAct=EBI-12814117, EBI-1049298;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Uniformly distributed within the cell, but becomes recruited to
CC the nucleus upon binding to HEY1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCDC89 family. {ECO:0000305}.
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DR EMBL; AK095478; BAC04556.1; -; mRNA.
DR EMBL; BC044814; AAH44814.1; -; mRNA.
DR CCDS; CCDS8270.1; -.
DR RefSeq; NP_689936.1; NM_152723.2.
DR AlphaFoldDB; Q8N998; -.
DR SMR; Q8N998; -.
DR BioGRID; 128643; 18.
DR IntAct; Q8N998; 17.
DR STRING; 9606.ENSP00000320649; -.
DR iPTMnet; Q8N998; -.
DR PhosphoSitePlus; Q8N998; -.
DR BioMuta; CCDC89; -.
DR DMDM; 74729632; -.
DR EPD; Q8N998; -.
DR MassIVE; Q8N998; -.
DR PaxDb; Q8N998; -.
DR PeptideAtlas; Q8N998; -.
DR PRIDE; Q8N998; -.
DR ProteomicsDB; 72509; -.
DR Antibodypedia; 49524; 85 antibodies from 11 providers.
DR DNASU; 220388; -.
DR Ensembl; ENST00000316398.5; ENSP00000320649.3; ENSG00000179071.5.
DR GeneID; 220388; -.
DR KEGG; hsa:220388; -.
DR MANE-Select; ENST00000316398.5; ENSP00000320649.3; NM_152723.3; NP_689936.1.
DR UCSC; uc001pau.2; human.
DR CTD; 220388; -.
DR DisGeNET; 220388; -.
DR GeneCards; CCDC89; -.
DR HGNC; HGNC:26762; CCDC89.
DR HPA; ENSG00000179071; Tissue enriched (testis).
DR neXtProt; NX_Q8N998; -.
DR OpenTargets; ENSG00000179071; -.
DR PharmGKB; PA144596457; -.
DR VEuPathDB; HostDB:ENSG00000179071; -.
DR eggNOG; ENOG502QU10; Eukaryota.
DR GeneTree; ENSGT00390000016046; -.
DR HOGENOM; CLU_066884_0_0_1; -.
DR InParanoid; Q8N998; -.
DR OMA; AMLCSRI; -.
DR OrthoDB; 1122259at2759; -.
DR PhylomeDB; Q8N998; -.
DR TreeFam; TF333232; -.
DR PathwayCommons; Q8N998; -.
DR SignaLink; Q8N998; -.
DR BioGRID-ORCS; 220388; 13 hits in 1065 CRISPR screens.
DR GenomeRNAi; 220388; -.
DR Pharos; Q8N998; Tdark.
DR PRO; PR:Q8N998; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N998; protein.
DR Bgee; ENSG00000179071; Expressed in left testis and 95 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR043450; CCDC89-like.
DR PANTHER; PTHR34768; PTHR34768; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..374
FT /note="Coiled-coil domain-containing protein 89"
FT /id="PRO_0000271024"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..351
FT /evidence="ECO:0000255"
FT COMPBIAS 15..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9DA73"
SQ SEQUENCE 374 AA; 43809 MW; 161160AC06AC1491 CRC64;
MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA NLRGLSEEER
SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE LEEKMMQEAE KLKAQGEYSR
KLEERFMTLA ANHELMLRFK DEYKSENIKL REENEKLRLE NSSLFSQALK DEEAKVLQLT
VRCEALTGEL ETLKERCAQD ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH
QQAVEQIAKA EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL
EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA FKKHSLDLLS
KERELNGKLR HLSP
