ID   CCD89_MACFA             Reviewed;         374 AA.
AC   Q95JI9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Coiled-coil domain-containing protein 89;
DE   AltName: Full=Bc8 orange-interacting protein;
GN   Name=CCDC89; Synonyms=BOIP; ORFNames=QtsA-17020;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14648848; DOI=10.1002/dvdy.10406;
RA   Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S.,
RA   Gessler M., Christophe D., Bellefroid E.J.;
RT   "Identification of BOIP, a novel cDNA highly expressed during
RT   spermatogenesis that encodes a protein interacting with the orange domain
RT   of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.";
RL   Dev. Dyn. 228:716-725(2003).
CC   -!- SUBUNIT: Interacts with HEY1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Uniformly distributed within the cell, but becomes recruited to
CC       the nucleus upon binding to HEY1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCDC89 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB070192; BAB63137.1; -; mRNA.
DR   RefSeq; NP_001274654.1; NM_001287725.1.
DR   RefSeq; XP_015290848.1; XM_015435362.1.
DR   RefSeq; XP_015290849.1; XM_015435363.1.
DR   RefSeq; XP_015290850.1; XM_015435364.1.
DR   RefSeq; XP_015290851.1; XM_015435365.1.
DR   RefSeq; XP_015290852.1; XM_015435366.1.
DR   RefSeq; XP_015290853.1; XM_015435367.1.
DR   RefSeq; XP_015290854.1; XM_015435368.1.
DR   RefSeq; XP_015290855.1; XM_015435369.1.
DR   RefSeq; XP_015290856.1; XM_015435370.1.
DR   RefSeq; XP_015290857.1; XM_015435371.1.
DR   RefSeq; XP_015290858.1; XM_015435372.1.
DR   AlphaFoldDB; Q95JI9; -.
DR   SMR; Q95JI9; -.
DR   STRING; 9541.XP_005579307.1; -.
DR   PRIDE; Q95JI9; -.
DR   GeneID; 102147065; -.
DR   KEGG; mcf:102147065; -.
DR   CTD; 220388; -.
DR   VEuPathDB; HostDB:ENSMFAG00000015719; -.
DR   eggNOG; ENOG502QU10; Eukaryota.
DR   OMA; AMLCSRI; -.
DR   OrthoDB; 1122259at2759; -.
DR   Proteomes; UP000233100; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR043450; CCDC89-like.
DR   PANTHER; PTHR34768; PTHR34768; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..374
FT                   /note="Coiled-coil domain-containing protein 89"
FT                   /id="PRO_0000271025"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..350
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        14..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         16
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DA73"
SQ   SEQUENCE   374 AA;  43881 MW;  59DE0DC4F50672A8 CRC64;
     MRAPMPQKEQ APRMDTSPPE ERLEKQNEKL NNQEEEMEFK ELDDLREALA NLRGLSEEER
     SEKAMLRSRI EDQSQLICIL KRRSDEALER CQILELLNAE LEEKMMQEAE KLKAQGEYTR
     KLEERFMTLA ANHELMIRFK DEYKSENIKL REENEKLKLE NSSLFSQALK DEEAKVLQLT
     VRCEALTGEL ETLKERCAQD ACQAQAREKE LLELQSQQAC THTKKTEQLR SQLQTLKQQH
     QQAVEQMAEA EETHSSLSQE LQARLQTVTR EKEELLQLSM ERGKVLQNKQ AEIRQLEEKL
     EIANEGRKHA LERFKQEAVA VDSNLRVREL QCKVDGIQKA YDELRLQSEA FKKHSLDLLS
     KERELNGKLR HLFP