CCD89_MOUSE
ID CCD89_MOUSE Reviewed; 370 AA.
AC Q9DA73;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Coiled-coil domain-containing protein 89 {ECO:0000250|UniProtKB:Q8N998};
DE AltName: Full=Bc8 orange-interacting protein {ECO:0000303|PubMed:14648848};
GN Name=Ccdc89 {ECO:0000312|MGI:MGI:1917304};
GN Synonyms=Boip {ECO:0000303|PubMed:14648848};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAB24410.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-370.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB24410.1};
RC TISSUE=Testis {ECO:0000312|EMBL:BAB24410.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305}
RP IDENTIFICATION, INTERACTION WITH HEY1, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=14648848; DOI=10.1002/dvdy.10406;
RA Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S.,
RA Gessler M., Christophe D., Bellefroid E.J.;
RT "Identification of BOIP, a novel cDNA highly expressed during
RT spermatogenesis that encodes a protein interacting with the orange domain
RT of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.";
RL Dev. Dyn. 228:716-725(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with HEY1. {ECO:0000269|PubMed:14648848}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7ZW57}. Nucleus
CC {ECO:0000250|UniProtKB:Q7ZW57}. Note=Uniformly distributed within the
CC cell, but becomes recruited to the nucleus upon binding to HEY1.
CC {ECO:0000250|UniProtKB:Q7ZW57}.
CC -!- TISSUE SPECIFICITY: Expression is restricted to the adult testis, where
CC localization is almost exclusive to round spermatids.
CC {ECO:0000269|PubMed:14648848}.
CC -!- DEVELOPMENTAL STAGE: Expressed in adults but not embryos.
CC {ECO:0000269|PubMed:14648848}.
CC -!- SIMILARITY: Belongs to the CCDC89 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24410.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB24410.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AC100322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK006105; BAB24410.1; ALT_SEQ; mRNA.
DR CCDS; CCDS52308.1; -.
DR RefSeq; NP_081574.1; NM_027298.1.
DR AlphaFoldDB; Q9DA73; -.
DR SMR; Q9DA73; -.
DR IntAct; Q9DA73; 1.
DR STRING; 10090.ENSMUSP00000060309; -.
DR iPTMnet; Q9DA73; -.
DR PhosphoSitePlus; Q9DA73; -.
DR PaxDb; Q9DA73; -.
DR PRIDE; Q9DA73; -.
DR ProteomicsDB; 265602; -.
DR Antibodypedia; 49524; 85 antibodies from 11 providers.
DR Ensembl; ENSMUST00000061391; ENSMUSP00000060309; ENSMUSG00000044362.
DR GeneID; 70054; -.
DR KEGG; mmu:70054; -.
DR UCSC; uc012fox.1; mouse.
DR CTD; 220388; -.
DR MGI; MGI:1917304; Ccdc89.
DR VEuPathDB; HostDB:ENSMUSG00000044362; -.
DR eggNOG; ENOG502QU10; Eukaryota.
DR GeneTree; ENSGT00390000016046; -.
DR HOGENOM; CLU_066884_0_0_1; -.
DR InParanoid; Q9DA73; -.
DR OMA; AMLCSRI; -.
DR OrthoDB; 1122259at2759; -.
DR PhylomeDB; Q9DA73; -.
DR TreeFam; TF333232; -.
DR BioGRID-ORCS; 70054; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9DA73; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9DA73; protein.
DR Bgee; ENSMUSG00000044362; Expressed in seminiferous tubule of testis and 98 other tissues.
DR Genevisible; Q9DA73; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:MGI.
DR InterPro; IPR043450; CCDC89-like.
DR PANTHER; PTHR34768; PTHR34768; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..370
FT /note="Coiled-coil domain-containing protein 89"
FT /id="PRO_0000370201"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 36..346
FT /evidence="ECO:0000255"
FT MOD_RES 12
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 107
FT /note="K -> E (in Ref. 2; BAB24410)"
FT /evidence="ECO:0000305"
FT CONFLICT 116..117
FT /note="QK -> KM (in Ref. 2; BAB24410)"
FT /evidence="ECO:0000305"
FT CONFLICT 224..225
FT /note="EL -> DV (in Ref. 2; BAB24410)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 43241 MW; 197E380266AC2064 CRC64;
MPQEEKTLRM DTPPPDEILG KQNENLQNQD EELGFKEMDG LREALANLRG LSEEEKGEKA
MLRSRIQEQS QLICILKRRS DEALERCQIL ELLNSELEEK RLQEMEKLKA QSEHIQKLEN
HFMILASNHE QMIRFKDAHK SENVKLKEEN ARLRQENNSL FSQALKDQEA KVLELTTLNK
ALVEELEVLK QRCAHEASQA QAREEELLGL QNQQACDHAK ETEELRSQLQ SIKQQHQQAT
EQMGKEQEAN LNLNQELQAR LQTVLREKEE LLQLSMERGK VLQNKQAEIR QLEEKLETAA
MAKKHALERF EQEAVAVDSN LRVRELQRRV DGIQKAYDEL RLQSEAFKKH SLDLLSKERE
LNAKLRHLFP
