ID   CCD89_RAT               Reviewed;         370 AA.
AC   B2RZ86;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Coiled-coil domain-containing protein 89 {ECO:0000312|RGD:1305335};
DE   AltName: Full=Bc8 orange-interacting protein {ECO:0000303|PubMed:14648848};
GN   Name=Ccdc89 {ECO:0000312|EMBL:AAI67063.1, ECO:0000312|RGD:1305335};
GN   Synonyms=Boip {ECO:0000303|PubMed:14648848};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAI67063.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway {ECO:0000312|EMBL:AAI67063.1};
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI67063.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=14648848; DOI=10.1002/dvdy.10406;
RA   Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S.,
RA   Gessler M., Christophe D., Bellefroid E.J.;
RT   "Identification of BOIP, a novel cDNA highly expressed during
RT   spermatogenesis that encodes a protein interacting with the orange domain
RT   of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.";
RL   Dev. Dyn. 228:716-725(2003).
CC   -!- SUBUNIT: Interacts with HEY1. {ECO:0000250|UniProtKB:Q9DA73}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7ZW57}. Nucleus
CC       {ECO:0000250|UniProtKB:Q7ZW57}. Note=Uniformly distributed within the
CC       cell, but becomes recruited to the nucleus upon binding to HEY1.
CC       {ECO:0000250|UniProtKB:Q7ZW57}.
CC   -!- SIMILARITY: Belongs to the CCDC89 family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI67063.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC167063; AAI67063.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001128305.1; NM_001134833.2.
DR   RefSeq; XP_003748970.1; XM_003748922.4.
DR   RefSeq; XP_017446033.1; XM_017590544.1.
DR   AlphaFoldDB; B2RZ86; -.
DR   SMR; B2RZ86; -.
DR   STRING; 10116.ENSRNOP00000024095; -.
DR   iPTMnet; B2RZ86; -.
DR   PhosphoSitePlus; B2RZ86; -.
DR   PaxDb; B2RZ86; -.
DR   Ensembl; ENSRNOT00000074282; ENSRNOP00000064997; ENSRNOG00000048071.
DR   GeneID; 293107; -.
DR   KEGG; rno:293107; -.
DR   UCSC; RGD:1305335; rat.
DR   CTD; 220388; -.
DR   RGD; 1305335; Ccdc89.
DR   eggNOG; ENOG502QU10; Eukaryota.
DR   GeneTree; ENSGT00390000016046; -.
DR   HOGENOM; CLU_066884_0_0_1; -.
DR   InParanoid; B2RZ86; -.
DR   OMA; AMLCSRI; -.
DR   OrthoDB; 1122259at2759; -.
DR   PhylomeDB; B2RZ86; -.
DR   TreeFam; TF333232; -.
DR   PRO; PR:B2RZ86; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000022766; Expressed in testis and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR043450; CCDC89-like.
DR   PANTHER; PTHR34768; PTHR34768; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Coiled-coil domain-containing protein 89"
FT                   /id="PRO_0000370202"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          36..346
FT                   /evidence="ECO:0000255"
FT   MOD_RES         12
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DA73"
SQ   SEQUENCE   370 AA;  43453 MW;  9187A4E43ABE12C2 CRC64;
     MPQKEKTLRM DTPPPDEILG RQNENLENED DELGFKEMDG LREALANLRG LSEEEKGEKA
     MLRSRIQEQS QLICILKRRS DEALERCQIL ELLNSELEEK RMQEMEKMKV QNEQVQKLES
     RFMTLAANHE LMIRFKDEHK SENIKLKEEN EKLRQENNSL FSQALKDQEN KVLQLTAHNK
     ALVEELEVLK QRCAHEAGQA RAREEELLAL QNQQACEHAK ETEQLRSQLQ SIKQQHRQAT
     EQMGKDQEAN INMNQELQAR LHTVMREKEE LLQLSMERGK VLQNKQAEIR QLEEKLETAA
     MAKKHALERF EQEAVAVDSN LRVRELQRKV DGIQKAYDDL RLQSEAFKKH SLDLLSKERE
     LNAKLRHLFP