CCD89_XENLA
ID CCD89_XENLA Reviewed; 334 AA.
AC Q7ZW57; B7ZQE4; B7ZQF0; Q32NH5; Q7ZW52; Q7ZW53; Q7ZW54; Q7ZW55; Q7ZW56;
AC Q7ZW58;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Coiled-coil domain-containing protein 89 {ECO:0000250|UniProtKB:Q8N998};
DE AltName: Full=Bc8 orange-interacting protein {ECO:0000312|EMBL:CAD87598.1};
DE Short=XBoip;
GN Name=ccdc89 {ECO:0000250|UniProtKB:Q8N998};
GN Synonyms=boip {ECO:0000312|EMBL:CAD87598.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD87598.1}
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HEY1, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Neurula {ECO:0000312|EMBL:CAD87598.1};
RX PubMed=14648848; DOI=10.1002/dvdy.10406;
RA Van Wayenbergh R., Taelman V., Pichon B., Fischer A., Kricha S.,
RA Gessler M., Christophe D., Bellefroid E.J.;
RT "Identification of BOIP, a novel cDNA highly expressed during
RT spermatogenesis that encodes a protein interacting with the orange domain
RT of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.";
RL Dev. Dyn. 228:716-725(2003).
RN [2] {ECO:0000312|EMBL:AAI69777.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI69777.1}, and
RC Testis {ECO:0000312|EMBL:AAI08623.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Interacts (via C-terminus) with hey1/bc8 (via Orange domain).
CC {ECO:0000269|PubMed:14648848}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14648848}. Nucleus
CC {ECO:0000269|PubMed:14648848}. Note=Uniformly distributed within the
CC cell, but becomes recruited to the nucleus upon binding to hey1/bc8.
CC {ECO:0000269|PubMed:14648848}.
CC -!- TISSUE SPECIFICITY: In adults, expressed at varying levels in different
CC organs including the liver and brain, with highest expression in the
CC testis. {ECO:0000269|PubMed:14648848}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed in all embryonic stages, with expression increasing during
CC development. {ECO:0000269|PubMed:14648848}.
CC -!- SIMILARITY: Belongs to the CCDC89 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI08623.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ555186; CAD87597.1; -; mRNA.
DR EMBL; AJ555187; CAD87598.1; -; mRNA.
DR EMBL; AJ555188; CAD87599.1; -; mRNA.
DR EMBL; AJ555189; CAD87600.1; -; mRNA.
DR EMBL; AJ555190; CAD87601.1; -; mRNA.
DR EMBL; AJ555191; CAD87602.1; -; mRNA.
DR EMBL; AJ555192; CAD87603.1; -; mRNA.
DR EMBL; BC108622; AAI08623.1; ALT_INIT; mRNA.
DR EMBL; BC169777; AAI69777.1; -; mRNA.
DR EMBL; BC169783; AAI69783.1; -; mRNA.
DR RefSeq; NP_001082584.1; NM_001089115.1.
DR AlphaFoldDB; Q7ZW57; -.
DR SMR; Q7ZW57; -.
DR BioGRID; 99916; 1.
DR GeneID; 398585; -.
DR KEGG; xla:398585; -.
DR CTD; 398585; -.
DR Xenbase; XB-GENE-5853499; ccdc89.L.
DR OrthoDB; 1122259at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 398585; Expressed in testis and 17 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR InterPro; IPR043450; CCDC89-like.
DR PANTHER; PTHR34768; PTHR34768; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..334
FT /note="Coiled-coil domain-containing protein 89"
FT /id="PRO_0000370204"
FT COILED 75..318
FT /evidence="ECO:0000255"
FT CONFLICT 2
FT /note="P -> Q (in Ref. 1; CAD87599)"
FT /evidence="ECO:0000305"
FT CONFLICT 77..92
FT /note="Missing (in Ref. 1; CAD87603)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="Q -> E (in Ref. 1; CAD87597/CAD87600/CAD87601)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="S -> K (in Ref. 1; CAD87598 and 2; AAI69783)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="S -> R (in Ref. 1; CAD87602)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="G -> E (in Ref. 1; CAD87599/CAD87603 and 2;
FT AAI08623/AAI69777)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="R -> H (in Ref. 1; CAD87597/CAD87600/CAD87601/
FT CAD87602)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="E -> G (in Ref. 1; CAD87600)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="K -> R (in Ref. 1; CAD87602 and 2; AAI69783)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="D -> E (in Ref. 1; CAD87599/CAD87602/CAD87603 and 2;
FT AAI08623/AAI69777)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="S -> R (in Ref. 1; CAD87599/CAD87603 and 2;
FT AAI69777)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="A -> V (in Ref. 1; CAD87597/CAD87600/CAD87601)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 39492 MW; 2464FC0397B6B12D CRC64;
MPGGEGENRV GEGIQSLKQL HALPWDEKTE NEMLRSRLDE QSQLICMLKQ RADETQIKWQ
HLERVNGELE RQSGEAAQRF QSERERGERL EERFAILASN HQQMIRFKDE YKQQNEELRQ
LCDTMRESKY PELLHRDRCI QELRDQLGDT ETRLKEQEMN YGRKLDTLSA KVEQLEGEKR
TGSLELGDLT HRLKVSEETR HEAQEKLARL EEIKKAEKAE ADKRLEEIKK EKQELLNLCM
ERGRTLQDRQ REAAELSVRL QEAQKSLEKA EESYQRDKAA VDADIRVSDL QRKLEDGENQ
FEQLRRDFEA YKKHSGDLLT KERELNSKLR HLIG
