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CCD91_PONAB
ID   CCD91_PONAB             Reviewed;         405 AA.
AC   Q5RCA7;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Coiled-coil domain-containing protein 91;
DE   AltName: Full=GGA-binding partner;
GN   Name=CCDC91; Synonyms=GGABP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of membrane traffic through the
CC       trans-Golgi network (TGN). Functions in close cooperation with the GGAs
CC       in the sorting of hydrolases to lysosomes.
CC       {ECO:0000250|UniProtKB:Q7Z6B0}.
CC   -!- SUBUNIT: Homodimer. Interacts with GGA1, GGA2 and AP1G1.
CC       {ECO:0000250|UniProtKB:Q7Z6B0}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q7Z6B0};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q7Z6B0}. Golgi
CC       apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q7Z6B0};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q7Z6B0}. Golgi
CC       apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q7Z6B0}.
CC       Note=Colocalizes with GGA1, GGA2 and GGA3.
CC       {ECO:0000250|UniProtKB:Q7Z6B0}.
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DR   EMBL; CR858371; CAH90600.1; -; mRNA.
DR   RefSeq; NP_001127307.1; NM_001133835.1.
DR   AlphaFoldDB; Q5RCA7; -.
DR   SMR; Q5RCA7; -.
DR   GeneID; 100174368; -.
DR   KEGG; pon:100174368; -.
DR   CTD; 55297; -.
DR   eggNOG; ENOG502QW5U; Eukaryota.
DR   InParanoid; Q5RCA7; -.
DR   OrthoDB; 780637at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0090160; P:Golgi to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR034592; CCDC91.
DR   PANTHER; PTHR35072; PTHR35072; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..405
FT                   /note="Coiled-coil domain-containing protein 91"
FT                   /id="PRO_0000087480"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1..16
FT                   /note="GGA1-binding motif"
FT                   /evidence="ECO:0000250"
FT   REGION          210..377
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   COILED          126..376
FT                   /evidence="ECO:0000255"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AY97"
FT   MOD_RES         46
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AY97"
SQ   SEQUENCE   405 AA;  46030 MW;  B5D4E916640789F2 CRC64;
     MDDDDFGGFE AAETFDGGNG ETQTTSPAIP WAAFPTVSGV HLSPPSPEIV LDHDHSSAID
     CLSSDAIISS PENTHAENSI VSQTIPKAQI QQSTHTHLDI SLFPLGLTDE KSNGTIALVD
     DSEDPGANVS NIQLRQKISS LEIKLKVSEE EKQRIKQDVE SLMEKHNVLE KGFLKEKEQE
     AISFQDRYKE LQEKHKQELE DMRKAGHEAL SIIVDEYKHQ RLLEMLDTEK ELLKGKIKEA
     LIQQSQEQKE ILEKCLEEER QRNKEALVSA AKLEKEAMKD AVLKVVEEER KNSEKAHAEE
     RELWKTEHAK DQEKVSQEIQ KAIQEQRKIS QETVKAAIIE EQKRSEKAVE EAVKRTRDEL
     IEYIKEQKRL DQVIRQRSLS SLELFLSCAQ KQLSALIATE PVDIE
 
 
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