CCD92_MOUSE
ID CCD92_MOUSE Reviewed; 314 AA.
AC Q8VDN4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Coiled-coil domain-containing protein 92;
GN Name=Ccdc92; Synonyms=D5Bwg0834e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Interferon-stimulated protein that plays a role in innate
CC immunity. {ECO:0000250|UniProtKB:Q53HC0}.
CC -!- SUBUNIT: Interacts with CEP164. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:Q53HC0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q53HC0}.
CC -!- PTM: Phosphorylated at Ser-192 by TTBK2.
CC {ECO:0000250|UniProtKB:Q53HC0}.
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DR EMBL; AK165371; BAE38150.1; -; mRNA.
DR EMBL; BC021492; AAH21492.1; -; mRNA.
DR CCDS; CCDS19681.1; -.
DR RefSeq; NP_659068.1; NM_144819.2.
DR RefSeq; XP_006504350.1; XM_006504287.3.
DR AlphaFoldDB; Q8VDN4; -.
DR SMR; Q8VDN4; -.
DR BioGRID; 229650; 3.
DR STRING; 10090.ENSMUSP00000038075; -.
DR iPTMnet; Q8VDN4; -.
DR PhosphoSitePlus; Q8VDN4; -.
DR EPD; Q8VDN4; -.
DR jPOST; Q8VDN4; -.
DR MaxQB; Q8VDN4; -.
DR PaxDb; Q8VDN4; -.
DR PeptideAtlas; Q8VDN4; -.
DR PRIDE; Q8VDN4; -.
DR ProteomicsDB; 281419; -.
DR Antibodypedia; 52615; 120 antibodies from 20 providers.
DR DNASU; 215707; -.
DR Ensembl; ENSMUST00000036206; ENSMUSP00000038075; ENSMUSG00000037979.
DR GeneID; 215707; -.
DR KEGG; mmu:215707; -.
DR UCSC; uc008zqr.1; mouse.
DR CTD; 80212; -.
DR MGI; MGI:106485; Ccdc92.
DR VEuPathDB; HostDB:ENSMUSG00000037979; -.
DR eggNOG; ENOG502QQWS; Eukaryota.
DR GeneTree; ENSGT00430000031027; -.
DR HOGENOM; CLU_076253_0_0_1; -.
DR InParanoid; Q8VDN4; -.
DR OMA; AHRIHHG; -.
DR OrthoDB; 1565079at2759; -.
DR PhylomeDB; Q8VDN4; -.
DR TreeFam; TF329066; -.
DR BioGRID-ORCS; 215707; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ccdc92; mouse.
DR PRO; PR:Q8VDN4; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8VDN4; protein.
DR Bgee; ENSMUSG00000037979; Expressed in animal zygote and 156 other tissues.
DR ExpressionAtlas; Q8VDN4; baseline and differential.
DR Genevisible; Q8VDN4; MM.
DR GO; GO:0005814; C:centriole; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR040370; CCDC74A/CCDC74B/CCDC92.
DR InterPro; IPR033224; CCDC92.
DR InterPro; IPR039496; CCDC92/74_CC_dom.
DR PANTHER; PTHR14882; PTHR14882; 1.
DR PANTHER; PTHR14882:SF4; PTHR14882:SF4; 1.
DR Pfam; PF14916; CCDC92; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Immunity; Innate immunity;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..314
FT /note="Coiled-coil domain-containing protein 92"
FT /id="PRO_0000274501"
FT REGION 153..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..27
FT /evidence="ECO:0000255"
FT COILED 59..113
FT /evidence="ECO:0000255"
FT COMPBIAS 179..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 192
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53HC0"
SQ SEQUENCE 314 AA; 35207 MW; 2CE8F50B158A04E5 CRC64;
MAATNLENQL HSAQKNLLFL QREHASTLKG LHAEIRRLQQ HCTDLTYELT LKSFELTGDS
SSRTTELKRR CEELEAQLKA KEEENRKLLQ ELEQKNAAIA VLENTVRERE KKYLEELKVK
SHKLSMLSGE LEQRASTVAY LTSQLHAAKK KLLSSSGTSD ASPAGSPALA SYKPTPPKDK
LPETPRRRMK KSLSAPLHPE FEEVYRFGAE SRKLLLREPV DAMPDPTPFL LARESAEVQL
KERPLVIPPI ASDRSATGQH SPARDKPHKT HVGVAHRIHH ATPSQAQPEG EMRAVDQVNA
SKVVRKHSGT DRTV
