CCD93_MOUSE
ID CCD93_MOUSE Reviewed; 629 AA.
AC Q7TQK5; Q3TX53;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 93;
GN Name=Ccdc93;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the CCC complex, which is involved in the
CC regulation of endosomal recycling of surface proteins, including
CC integrins, signaling receptor and channels. The CCC complex associates
CC with SNX17, retriever and WASH complexes to prevent lysosomal
CC degradation and promote cell surface recycling of numerous cargos such
CC as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A
CC trafficking between the trans-Golgi network and vesicles in the cell
CC periphery; the function is proposed to depend on its association within
CC the CCC complex and cooperation with the WASH complex on early
CC endosomes and is dependent on its interaction with WASHC2C.
CC {ECO:0000250|UniProtKB:Q567U6}.
CC -!- SUBUNIT: Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6,
CC COMMD7, COMMD8, COMMD9, COMMD10, WASHC1. Interacts directly with
CC WASHC2C. Interacts with CCDC93; proposed to be a component of the CCC
CC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and
CC possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in
CC the complex interacts directly with CCDC22. Interacts with VPS35L;
CC associates with the retriever complex. Interacts with SNX17 and SNX31.
CC {ECO:0000250|UniProtKB:Q567U6}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q567U6}.
CC -!- SIMILARITY: Belongs to the CCDC93 family. {ECO:0000305}.
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DR EMBL; AK142302; BAE25021.1; -; mRNA.
DR EMBL; AK159415; BAE35063.1; -; mRNA.
DR EMBL; BC054083; AAH54083.1; -; mRNA.
DR CCDS; CCDS15237.1; -.
DR RefSeq; NP_001020327.1; NM_001025156.2.
DR AlphaFoldDB; Q7TQK5; -.
DR SMR; Q7TQK5; -.
DR BioGRID; 214279; 7.
DR IntAct; Q7TQK5; 2.
DR STRING; 10090.ENSMUSP00000043442; -.
DR iPTMnet; Q7TQK5; -.
DR PhosphoSitePlus; Q7TQK5; -.
DR EPD; Q7TQK5; -.
DR MaxQB; Q7TQK5; -.
DR PaxDb; Q7TQK5; -.
DR PeptideAtlas; Q7TQK5; -.
DR PRIDE; Q7TQK5; -.
DR ProteomicsDB; 265605; -.
DR Antibodypedia; 33361; 242 antibodies from 20 providers.
DR Ensembl; ENSMUST00000036025; ENSMUSP00000043442; ENSMUSG00000026339.
DR GeneID; 70829; -.
DR KEGG; mmu:70829; -.
DR UCSC; uc007cju.2; mouse.
DR CTD; 54520; -.
DR MGI; MGI:1918079; Ccdc93.
DR VEuPathDB; HostDB:ENSMUSG00000026339; -.
DR eggNOG; KOG2701; Eukaryota.
DR GeneTree; ENSGT00390000011294; -.
DR InParanoid; Q7TQK5; -.
DR OMA; QYYTLYN; -.
DR OrthoDB; 1091136at2759; -.
DR PhylomeDB; Q7TQK5; -.
DR TreeFam; TF323318; -.
DR BioGRID-ORCS; 70829; 10 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc93; mouse.
DR PRO; PR:Q7TQK5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q7TQK5; protein.
DR Bgee; ENSMUSG00000026339; Expressed in iris and 240 other tissues.
DR ExpressionAtlas; Q7TQK5; baseline and differential.
DR Genevisible; Q7TQK5; MM.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR039116; CCDC93.
DR InterPro; IPR019159; CCDC93_CC.
DR PANTHER; PTHR16441; PTHR16441; 1.
DR Pfam; PF09762; CCDC93_CC; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endosome; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..629
FT /note="Coiled-coil domain-containing protein 93"
FT /id="PRO_0000234605"
FT REGION 1..428
FT /note="Sufficient for interaction with CCDC22"
FT /evidence="ECO:0000250|UniProtKB:Q567U6"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..629
FT /note="Sufficient for interaction with WASHC2C"
FT /evidence="ECO:0000250|UniProtKB:Q567U6"
FT COILED 231..430
FT /evidence="ECO:0000255"
FT COILED 558..599
FT /evidence="ECO:0000255"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q567U6"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q567U6"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q567U6"
FT CONFLICT 106
FT /note="H -> L (in Ref. 1; BAE35063)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="Y -> N (in Ref. 1; BAE35063)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 629 AA; 72603 MW; 77404E34035FA440 CRC64;
MGLPKGPEGQ GLPEVETRED EEQNVKLTEI LELLVAAGYF RARIKGLSPF DKVVGGMTWC
ITTCSFDVDV DLLFQENSTI GQKIALSEKI VSVLPRMKCP HQLEPHQIQG MDFIHIFPVV
QWLVKRAIET KEEMGDYIRS YSISQFQKTY SLPEDDDFIK RKDKAVKTVV GLSDAYKPRR
KYRRQRGAEE LPDEESRVHS TLLEYGRRYG FSRQSKTEKA EDKKTALAAG LSAAEKVDAH
EEDELQAAEE QRIQSLMTKM TAMANEESRL TASSVGQIVG LCSEEIKQIV SEYAGKQSEL
SAEESPEKLG TSQLHQRKVI SLNKQILQKS KHLEELQANH TSLKAKYSDR KKTLTELKDH
GEKLDKEQAA LEKLEAKADP SMLQNLRALV AMNESLKSQE QEFKAHCREE MARLQQEIET
LKAERAPGEK IISGGEPQGA LTSTMTHNED LDRRYNMEKE KLYKIRLLQA RRNREIAILH
RKIDEVPSRA ELIQYQKRFI ELYRQISAVH KETKQFFTLY NTLDDKKVYL EKEISLLNSI
HENFSQAMAS PAARDQFLRQ MEQIVEGIKQ SRMKMEKKKQ ENKMRRDQLN DQYLELLEKQ
RLYFKTVKEF KEEGRKNELL LSKIKAKAS
