ID   CCD96_HUMAN             Reviewed;         555 AA.
AC   Q2M329; Q8N2I7;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Coiled-coil domain-containing protein 96;
GN   Name=CCDC96;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-96.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=25074808; DOI=10.1242/jcs.157008;
RA   Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT   "Proteomic analysis of mammalian sperm cells identifies new components of
RT   the centrosome.";
RL   J. Cell Sci. 127:4128-4133(2014).
CC   -!- INTERACTION:
CC       Q2M329; Q9UBB9: TFIP11; NbExp=4; IntAct=EBI-12382974, EBI-1105213;
CC       Q2M329; P09493-10: TPM1; NbExp=3; IntAct=EBI-12382974, EBI-12123928;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:25074808}.
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DR   EMBL; AK075056; BAC11373.1; -; mRNA.
DR   EMBL; BC105055; AAI05056.1; -; mRNA.
DR   EMBL; BC112274; AAI12275.1; -; mRNA.
DR   CCDS; CCDS3395.1; -.
DR   RefSeq; NP_699207.1; NM_153376.2.
DR   AlphaFoldDB; Q2M329; -.
DR   SMR; Q2M329; -.
DR   BioGRID; 129209; 161.
DR   IntAct; Q2M329; 4.
DR   STRING; 9606.ENSP00000309285; -.
DR   CarbonylDB; Q2M329; -.
DR   iPTMnet; Q2M329; -.
DR   PhosphoSitePlus; Q2M329; -.
DR   BioMuta; CCDC96; -.
DR   DMDM; 94707508; -.
DR   MassIVE; Q2M329; -.
DR   MaxQB; Q2M329; -.
DR   PaxDb; Q2M329; -.
DR   PeptideAtlas; Q2M329; -.
DR   PRIDE; Q2M329; -.
DR   ProteomicsDB; 61364; -.
DR   Antibodypedia; 55414; 63 antibodies from 15 providers.
DR   DNASU; 257236; -.
DR   Ensembl; ENST00000310085.6; ENSP00000309285.4; ENSG00000173013.6.
DR   GeneID; 257236; -.
DR   KEGG; hsa:257236; -.
DR   MANE-Select; ENST00000310085.6; ENSP00000309285.4; NM_153376.3; NP_699207.1.
DR   UCSC; uc003gjv.4; human.
DR   CTD; 257236; -.
DR   DisGeNET; 257236; -.
DR   GeneCards; CCDC96; -.
DR   HGNC; HGNC:26900; CCDC96.
DR   HPA; ENSG00000173013; Tissue enriched (testis).
DR   MIM; 619347; gene.
DR   neXtProt; NX_Q2M329; -.
DR   OpenTargets; ENSG00000173013; -.
DR   PharmGKB; PA144596463; -.
DR   VEuPathDB; HostDB:ENSG00000173013; -.
DR   eggNOG; ENOG502QS75; Eukaryota.
DR   GeneTree; ENSGT00950000183337; -.
DR   HOGENOM; CLU_026534_0_0_1; -.
DR   InParanoid; Q2M329; -.
DR   OMA; IRLNQKC; -.
DR   OrthoDB; 993645at2759; -.
DR   PhylomeDB; Q2M329; -.
DR   TreeFam; TF328830; -.
DR   PathwayCommons; Q2M329; -.
DR   SignaLink; Q2M329; -.
DR   BioGRID-ORCS; 257236; 19 hits in 1078 CRISPR screens.
DR   GenomeRNAi; 257236; -.
DR   Pharos; Q2M329; Tdark.
DR   PRO; PR:Q2M329; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q2M329; protein.
DR   Bgee; ENSG00000173013; Expressed in left testis and 105 other tissues.
DR   Genevisible; Q2M329; HS.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   InterPro; IPR025254; DUF4201.
DR   Pfam; PF13870; DUF4201; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..555
FT                   /note="Coiled-coil domain-containing protein 96"
FT                   /id="PRO_0000234096"
FT   REGION          1..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          305..441
FT                   /evidence="ECO:0000255"
FT   COILED          505..531
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        176..202
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         96
FT                   /note="E -> K (in dbSNP:rs871134)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_026162"
SQ   SEQUENCE   555 AA;  62711 MW;  4C3E430F16287E97 CRC64;
     MDVSSEHTKD PGGEGGDGES LAARPSKIKA SSGPPTSPEP GELESEPEEE EEEQAASQGG
     TAADEQAEAP KGLTAAEAAG EEGPGEPGRP AEPQPEPEEP AEVGAEEPAQ PEPGAGPEEL
     EAEAGAEELE QAAEGKEVRF QASLPLTRID EEEAAAAPEA ETERVEGEEE DKEETQRDGA
     ESKERDGEGR PAKSQEEGKR LYGRDEFEDL EWSEEVQKLQ EQQLRSDLLD QYRSLLVERN
     RSQRYNLYLQ HKIFEALRRK KGLEAAEVAD RGAEAEAPEK EQAYLRHLGM LEELKKQQAD
     DLQWYHQELG QLKRQCQEKL TRVEKEWRRF QALKKQVVMQ AMGSCRMRGG RQAALREVEQ
     IQALEDKKEK EMSAVRLENI QLKQSLVHFE TRMRTQEDLT QGLLLIDFEQ LKIENQTFNE
     KIEERNEELL KLRSKVTNSV QVITHVKEKL HFMDMENACK KTQLAEIEAQ AALGRDILTK
     TKQAREGLRT DNIRLNQKCG LLGKDSLLRD LEEKVDKTEL LHRRLESLKR HHASLTLSCR
     GVRQKIREAK AFLPS