CCD96_MOUSE
ID CCD96_MOUSE Reviewed; 584 AA.
AC Q9CR92;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Coiled-coil domain-containing protein 96;
GN Name=Ccdc96;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q2M329}.
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DR EMBL; AK014878; BAB29599.1; -; mRNA.
DR EMBL; AK015646; BAB29914.1; -; mRNA.
DR EMBL; AK030023; BAC26742.1; -; mRNA.
DR CCDS; CCDS19239.1; -.
DR RefSeq; NP_080001.1; NM_025725.2.
DR AlphaFoldDB; Q9CR92; -.
DR SMR; Q9CR92; -.
DR STRING; 10090.ENSMUSP00000059636; -.
DR PhosphoSitePlus; Q9CR92; -.
DR EPD; Q9CR92; -.
DR PaxDb; Q9CR92; -.
DR PRIDE; Q9CR92; -.
DR ProteomicsDB; 281321; -.
DR DNASU; 66717; -.
DR Ensembl; ENSMUST00000060100; ENSMUSP00000059636; ENSMUSG00000050677.
DR GeneID; 66717; -.
DR KEGG; mmu:66717; -.
DR UCSC; uc008xeq.1; mouse.
DR CTD; 257236; -.
DR MGI; MGI:1913967; Ccdc96.
DR VEuPathDB; HostDB:ENSMUSG00000050677; -.
DR eggNOG; ENOG502QS75; Eukaryota.
DR GeneTree; ENSGT00940000154521; -.
DR HOGENOM; CLU_026534_0_0_1; -.
DR InParanoid; Q9CR92; -.
DR OMA; IRLNQKC; -.
DR OrthoDB; 624230at2759; -.
DR PhylomeDB; Q9CR92; -.
DR TreeFam; TF328830; -.
DR BioGRID-ORCS; 66717; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc96; mouse.
DR PRO; PR:Q9CR92; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CR92; protein.
DR Bgee; ENSMUSG00000050677; Expressed in seminiferous tubule of testis and 47 other tissues.
DR Genevisible; Q9CR92; MM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR InterPro; IPR025254; DUF4201.
DR Pfam; PF13870; DUF4201; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..584
FT /note="Coiled-coil domain-containing protein 96"
FT /id="PRO_0000234098"
FT REGION 1..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..470
FT /evidence="ECO:0000255"
FT COILED 530..561
FT /evidence="ECO:0000255"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 67256 MW; 0F360DF474D78E18 CRC64;
MDSHYGDIEG KDRAEEGLAR QSLEIKVSSE PLTPANPVEQ EPEPKPEPEP TQGREPESET
QPVSDSSKAK DSEGIDYAHV EVPESPGAAE TAGEAVSREP ESLPQTQPKT KPESKEPEDK
DEDEDEDEDE DEDEDEDEDE DEDEGEERDR PEKPKGKGKR EKRKESRFRP SLPLTTIVEE
GAAPGPQAAK EKARESLKKR DSEEIEGTDR ERHKSTEEQL HPGEAKEEEK QKGASTEEFE
WTADMQKLQE QQLRGELVEQ YHSLLVERNR YQRYNMYLQQ KIHETLRKKG LEAAAEPGDK
SAEPESPEKE QAYLRYLAML EELKKQEADD LEWYRQEVRE LKQQCQEKQT RVEKEWRRFQ
ALKKQVVMQV MGSCRTRGGR QAALREVEQL QALEDKKEKE MSAVRLENVQ LKQSLVHFET
RMKAQEDLAE GLLLIDFEQL KIENQTFNEK VEERNEELLK LRTKVTSNVQ IITHVKEKLS
FIDTENSCKK AQLSEVDAQV ALGRDLLTKT KQARDSLRID NVKLSQKCGL LGKESLLRDL
EEKVEKTEML NRRLESLKRH HAGLALSCKG VKQKIREAKT FLPS
