CCD97_HUMAN
ID CCD97_HUMAN Reviewed; 343 AA.
AC Q96F63; Q658N6; Q96IF3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coiled-coil domain-containing protein 97;
GN Name=CCDC97;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-343.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND SER-337, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47; SER-275 AND SER-337, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
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DR EMBL; BC007575; AAH07575.1; -; mRNA.
DR EMBL; BC011577; AAH11577.1; -; mRNA.
DR EMBL; AL833726; CAH56251.1; -; mRNA.
DR CCDS; CCDS12578.1; -.
DR RefSeq; NP_443080.1; NM_052848.2.
DR AlphaFoldDB; Q96F63; -.
DR SMR; Q96F63; -.
DR BioGRID; 124693; 59.
DR IntAct; Q96F63; 22.
DR MINT; Q96F63; -.
DR STRING; 9606.ENSP00000269967; -.
DR GlyGen; Q96F63; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96F63; -.
DR PhosphoSitePlus; Q96F63; -.
DR BioMuta; CCDC97; -.
DR DMDM; 74731660; -.
DR EPD; Q96F63; -.
DR jPOST; Q96F63; -.
DR MassIVE; Q96F63; -.
DR MaxQB; Q96F63; -.
DR PaxDb; Q96F63; -.
DR PeptideAtlas; Q96F63; -.
DR PRIDE; Q96F63; -.
DR ProteomicsDB; 76498; -.
DR Antibodypedia; 48733; 133 antibodies from 20 providers.
DR DNASU; 90324; -.
DR Ensembl; ENST00000269967.4; ENSP00000269967.2; ENSG00000142039.4.
DR GeneID; 90324; -.
DR KEGG; hsa:90324; -.
DR MANE-Select; ENST00000269967.4; ENSP00000269967.2; NM_052848.3; NP_443080.1.
DR UCSC; uc002oqg.3; human.
DR CTD; 90324; -.
DR DisGeNET; 90324; -.
DR GeneCards; CCDC97; -.
DR HGNC; HGNC:28289; CCDC97.
DR HPA; ENSG00000142039; Low tissue specificity.
DR neXtProt; NX_Q96F63; -.
DR OpenTargets; ENSG00000142039; -.
DR PharmGKB; PA144596464; -.
DR VEuPathDB; HostDB:ENSG00000142039; -.
DR eggNOG; KOG3044; Eukaryota.
DR GeneTree; ENSGT00390000015495; -.
DR HOGENOM; CLU_058245_1_1_1; -.
DR InParanoid; Q96F63; -.
DR OMA; DSYDVRN; -.
DR OrthoDB; 1227195at2759; -.
DR PhylomeDB; Q96F63; -.
DR TreeFam; TF316152; -.
DR PathwayCommons; Q96F63; -.
DR SignaLink; Q96F63; -.
DR BioGRID-ORCS; 90324; 15 hits in 1085 CRISPR screens.
DR ChiTaRS; CCDC97; human.
DR GenomeRNAi; 90324; -.
DR Pharos; Q96F63; Tdark.
DR PRO; PR:Q96F63; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96F63; protein.
DR Bgee; ENSG00000142039; Expressed in granulocyte and 167 other tissues.
DR ExpressionAtlas; Q96F63; baseline and differential.
DR Genevisible; Q96F63; HS.
DR InterPro; IPR040233; CCD97-like_C.
DR InterPro; IPR018613; Ccdc97-like.
DR PANTHER; PTHR31840; PTHR31840; 1.
DR Pfam; PF09747; DUF2052; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..343
FT /note="Coiled-coil domain-containing protein 97"
FT /id="PRO_0000286096"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 224..262
FT /evidence="ECO:0000255"
FT COMPBIAS 244..262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT MOD_RES 47
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
SQ SEQUENCE 343 AA; 38947 MW; 5153E473FF0D2069 CRC64;
MEAVATATAA KEPDKGCIEP GPGHWGELSR TPVPSKPQDK VEAAEATPVA LDSDTSGAEN
AAVSAMLHAV AASRLPVCSQ QQGEPDLTEH EKVAILAQLY HEKPLVFLER FRTGLREEHL
ACFGHVRGDH RADFYCAEVA RQGTARPRTL RTRLRNRRYA ALRELIQGGE YFSDEQMRFR
APLLYEQYIG QYLTQEELSA RTPTHQPPKP GSPGRPACPL SNLLLQSYEE RELQQRLLQQ
QEEEEACLEE EEEEEDSDEE DQRSGKDSEA WVPDSEERLI LREEFTSRMH QRFLDGKDGD
FDYSTVDDNP DFDNLDIVAR DEEERYFDEE EPEDAPSPEL DGD
