CCD9B_HUMAN
ID CCD9B_HUMAN Reviewed; 534 AA.
AC Q6ZUT6; B9EIQ8; Q68DG9; Q6ZTM3; Q6ZU22;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 9B {ECO:0000312|HGNC:HGNC:33488};
GN Name=CCDC9B {ECO:0000312|HGNC:HGNC:33488};
GN Synonyms=C15orf52 {ECO:0000312|HGNC:HGNC:33488};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Teratocarcinoma, Testis, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-534 (ISOFORM 4).
RC TISSUE=Endometrial tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [10]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-189.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6ZUT6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUT6-2; Sequence=VSP_027037, VSP_027040;
CC Name=3;
CC IsoId=Q6ZUT6-3; Sequence=VSP_027038, VSP_027039, VSP_027041,
CC VSP_027042;
CC Name=4;
CC IsoId=Q6ZUT6-4; Sequence=VSP_027038, VSP_027039;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-45 is the initiator.
CC Initiation at Met-45 is supported by CAGE data but there is peptide
CC data to support translation initiation at Met-1. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH18251.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK125329; BAC86132.1; -; mRNA.
DR EMBL; AK126035; BAC86405.1; -; mRNA.
DR EMBL; AK126485; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471125; EAW92404.1; -; Genomic_DNA.
DR EMBL; BC140897; AAI40898.1; -; mRNA.
DR EMBL; BC140902; AAI40903.1; -; mRNA.
DR EMBL; CR749408; CAH18251.1; ALT_INIT; mRNA.
DR RefSeq; NP_997263.2; NM_207380.2. [Q6ZUT6-1]
DR AlphaFoldDB; Q6ZUT6; -.
DR SMR; Q6ZUT6; -.
DR BioGRID; 132557; 7.
DR IntAct; Q6ZUT6; 3.
DR STRING; 9606.ENSP00000453969; -.
DR iPTMnet; Q6ZUT6; -.
DR PhosphoSitePlus; Q6ZUT6; -.
DR BioMuta; C15orf52; -.
DR DMDM; 74712068; -.
DR EPD; Q6ZUT6; -.
DR jPOST; Q6ZUT6; -.
DR MassIVE; Q6ZUT6; -.
DR MaxQB; Q6ZUT6; -.
DR PaxDb; Q6ZUT6; -.
DR PeptideAtlas; Q6ZUT6; -.
DR PRIDE; Q6ZUT6; -.
DR ProteomicsDB; 68361; -. [Q6ZUT6-1]
DR ProteomicsDB; 68362; -. [Q6ZUT6-2]
DR ProteomicsDB; 68363; -. [Q6ZUT6-3]
DR ProteomicsDB; 68364; -. [Q6ZUT6-4]
DR Antibodypedia; 52258; 51 antibodies from 10 providers.
DR DNASU; 388115; -.
DR Ensembl; ENST00000397536.7; ENSP00000380670.3; ENSG00000188549.13.
DR GeneID; 388115; -.
DR KEGG; hsa:388115; -.
DR UCSC; uc001zlh.5; human. [Q6ZUT6-1]
DR CTD; 388115; -.
DR DisGeNET; 388115; -.
DR GeneCards; CCDC9B; -.
DR HGNC; HGNC:33488; CCDC9B.
DR HPA; ENSG00000188549; Low tissue specificity.
DR neXtProt; NX_Q6ZUT6; -.
DR PharmGKB; PA162378161; -.
DR VEuPathDB; HostDB:ENSG00000188549; -.
DR eggNOG; ENOG502S0JY; Eukaryota.
DR HOGENOM; CLU_857803_0_0_1; -.
DR InParanoid; Q6ZUT6; -.
DR OMA; RNWTRGT; -.
DR OrthoDB; 602532at2759; -.
DR PhylomeDB; Q6ZUT6; -.
DR TreeFam; TF336272; -.
DR PathwayCommons; Q6ZUT6; -.
DR SignaLink; Q6ZUT6; -.
DR BioGRID-ORCS; 388115; 12 hits in 1042 CRISPR screens.
DR GenomeRNAi; 388115; -.
DR Pharos; Q6ZUT6; Tdark.
DR PRO; PR:Q6ZUT6; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q6ZUT6; protein.
DR Bgee; ENSG00000188549; Expressed in apex of heart and 94 other tissues.
DR ExpressionAtlas; Q6ZUT6; baseline and differential.
DR Genevisible; Q6ZUT6; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR029336; DUF4594.
DR PANTHER; PTHR15635; PTHR15635; 1.
DR Pfam; PF15266; DUF4594; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..534
FT /note="Coiled-coil domain-containing protein 9B"
FT /id="PRO_0000295733"
FT REGION 173..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..97
FT /evidence="ECO:0000255"
FT COMPBIAS 198..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983"
FT VAR_SEQ 1..210
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027037"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027038"
FT VAR_SEQ 69..121
FT /note="RIVALRKKNQALLRRYQEIQEDRRQAEQGGMAVTTPALLQPDGLTVTISQVP
FT G -> MPLACEHPVGVSSSVGNAGRAGVGTQAWGTTERTQHPGPAQHCPCGLRVFVLQ
FT (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027039"
FT VAR_SEQ 211..215
FT /note="DSARK -> MRHRE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027040"
FT VAR_SEQ 293..325
FT /note="PRSHQKLQPPPLLPDGKGRGGQASRPSVAPATG -> EPTPTSSLPSLALFI
FT FHPLVLSFLCLLVSYFQS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027041"
FT VAR_SEQ 326..534
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027042"
FT VARIANT 189
FT /note="G -> E (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035620"
FT CONFLICT 236
FT /note="A -> T (in Ref. 1; BAC86405)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="S -> N (in Ref. 1; BAC86405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 534 AA; 57325 MW; 6439262849AB35D1 CRC64;
MISCAEQRSR QGEAGRGPAP VAPAFLPLWL PRGCSGILSV PAVAMHSAGT PRAESPMSRQ
EKDAELDRRI VALRKKNQAL LRRYQEIQED RRQAEQGGMA VTTPALLQPD GLTVTISQVP
GEKRVVSRNW ARGTCGPRVT NEMLEDEDAE DHGGTFCLGE LVELAVTMEN KAEGKRIVSE
KPTRARNQGI EGSPGGRVTR SPPTQVAISS DSARKGSWEP WSRPVGEPPE AGWDYAQWKQ
EREQIDLARL ARHRDAQGDW RRPWDLDKAK STLQDCSQLR GEGPARAGSR RGPRSHQKLQ
PPPLLPDGKG RGGQASRPSV APATGSKARG KERLTGRARR WDMKEDKEEL EGQEGSQSTR
ETPSEEEQAQ KQSGMEQGRL GSAPAASPAL ASPEGPKGES VASTASSVPC SPQEPDLAPL
DLSLGGAGIP GPRESGCVLG LRPGAQESPV SWPEGSKQQP LGWSNHQAEL EVQTCPEPQR
GAGLPEPGED RSGKSGAQQG LAPRSRPTRG GSQRSRGTAG VRRRTGRPGP AGRC
