ID   CCDB1_BOVIN             Reviewed;         358 AA.
AC   Q2KIZ9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Cyclin-D1-binding protein 1;
GN   Name=CCNDBP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate cell cycle progression. May act at
CC       least in part via inhibition of the cyclin-D1/CDK4 complex, thereby
CC       preventing phosphorylation of RB1 and blocking E2F-dependent
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5,
CC       RPLP0, SIRT6, SYF2 and TCF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCNDBP1 family. {ECO:0000305}.
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DR   EMBL; BC112447; AAI12448.1; -; mRNA.
DR   RefSeq; NP_001040069.1; NM_001046604.1.
DR   AlphaFoldDB; Q2KIZ9; -.
DR   SMR; Q2KIZ9; -.
DR   STRING; 9913.ENSBTAP00000017326; -.
DR   PaxDb; Q2KIZ9; -.
DR   PRIDE; Q2KIZ9; -.
DR   GeneID; 617512; -.
DR   KEGG; bta:617512; -.
DR   CTD; 23582; -.
DR   eggNOG; ENOG502SGCW; Eukaryota.
DR   InParanoid; Q2KIZ9; -.
DR   OrthoDB; 1249310at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR026907; CCNDBP1.
DR   PANTHER; PTHR15492; PTHR15492; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..358
FT                   /note="Cyclin-D1-binding protein 1"
FT                   /id="PRO_0000323371"
FT   REGION          1..207
FT                   /note="Required for interaction with CCND1"
FT                   /evidence="ECO:0000250"
FT   REGION          1..189
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   REGION          1..183
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          149..358
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          238..358
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   358 AA;  39664 MW;  D74A188ADE659D01 CRC64;
     MESAAVSAAP DATLDPPLEQ LRHLAGELRQ LLPGVRVGEA QETTKEFDRE AFWRRFNEAA
     VTVSREATTL TVAFSRLPLP SPQETQRFCE QVHAAIKAII GVYYLFPKDQ GITLRKLVRS
     ATLDIVDDMA QLVEALYINP AQSSPENLIS YNSVWDACQH VPQIPKDNKA AALSVLTKSV
     DLVKDAHEEM EQAVEECDPY CGLLNDIEED SSDNHVDEDI LGCPNNRDSY WSEEDQELII
     PCLALARASK ACLKKIRLSV AENGKKDQVA QLDDIVDISD EISPSVDDLA LSIYPPVCPL
     TVRINSAKLA SVLKKALEIT KASHVTPQPE DSWIPLLINA VDHCMNRIKE LTQNEVES