ID   CCDB1_MACFA             Reviewed;         332 AA.
AC   Q4R809;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Cyclin-D1-binding protein 1;
GN   Name=CCNDBP1; ORFNames=QtsA-13844;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate cell cycle progression. May act at
CC       least in part via inhibition of the cyclin-D1/CDK4 complex, thereby
CC       preventing phosphorylation of RB1 and blocking E2F-dependent
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5,
CC       RPLP0, SIRT6, SYF2 and TCF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCNDBP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB168652; BAE00763.1; -; mRNA.
DR   RefSeq; NP_001270015.1; NM_001283086.1.
DR   AlphaFoldDB; Q4R809; -.
DR   SMR; Q4R809; -.
DR   STRING; 9541.XP_005559380.1; -.
DR   GeneID; 101866754; -.
DR   CTD; 23582; -.
DR   eggNOG; ENOG502SGCW; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR026907; CCNDBP1.
DR   PANTHER; PTHR15492; PTHR15492; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
FT   CHAIN           2..332
FT                   /note="Cyclin-D1-binding protein 1"
FT                   /id="PRO_0000323373"
FT   REGION          2..208
FT                   /note="Required for interaction with CCND1"
FT                   /evidence="ECO:0000250"
FT   REGION          2..190
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   REGION          2..184
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          150..332
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          240..332
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
SQ   SEQUENCE   332 AA;  37034 MW;  E95B70FCD2492A7F CRC64;
     MASATAPAAA APTLAPPLQQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE MFWRRLNEAA
     VTVSREATTL TTVFSQLPLP SPQETQKFCE QVHAAIKAFI AVYYLLPKDQ GITLRKLVRG
     ATLDIVDGMA QLMEVLSITP TQSPENNDLI SYNSVWVACQ QMPQIPRDNK AAALLMLTKN
     VDFVKDAHEE MERAVEECDP YSGLLNDTDE NNSDNHNDED DVLGFPSNQD LYWSEDDQEL
     IIPCLALVRA SKACLKKIRI LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
     HLTVRINSAK LVSVLKKALM SAFKMELECL LD