ID   CCDB1_PONAB             Reviewed;         360 AA.
AC   Q5RFN4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Cyclin-D1-binding protein 1;
GN   Name=CCNDBP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate cell cycle progression. May act at
CC       least in part via inhibition of the cyclin-D1/CDK4 complex, thereby
CC       preventing phosphorylation of RB1 and blocking E2F-dependent
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5,
CC       RPLP0, SIRT6, SYF2 and TCF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCNDBP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR857119; CAH89423.1; -; mRNA.
DR   RefSeq; NP_001124602.1; NM_001131130.2.
DR   AlphaFoldDB; Q5RFN4; -.
DR   SMR; Q5RFN4; -.
DR   STRING; 9601.ENSPPYP00000007258; -.
DR   Ensembl; ENSPPYT00000007559; ENSPPYP00000007258; ENSPPYG00000006406.
DR   GeneID; 100171439; -.
DR   KEGG; pon:100171439; -.
DR   CTD; 23582; -.
DR   eggNOG; ENOG502SGCW; Eukaryota.
DR   GeneTree; ENSGT00390000018016; -.
DR   HOGENOM; CLU_067580_0_0_1; -.
DR   InParanoid; Q5RFN4; -.
DR   OrthoDB; 1249310at2759; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR026907; CCNDBP1.
DR   PANTHER; PTHR15492; PTHR15492; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
FT   CHAIN           2..360
FT                   /note="Cyclin-D1-binding protein 1"
FT                   /id="PRO_0000323375"
FT   REGION          2..208
FT                   /note="Required for interaction with CCND1"
FT                   /evidence="ECO:0000250"
FT   REGION          2..190
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   REGION          2..184
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          150..360
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          240..360
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
SQ   SEQUENCE   360 AA;  40177 MW;  D651759F160482F6 CRC64;
     MASATAPAAA VPTLASPLGQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE MFWRRLNEAA
     VTVSREATTL TTVFSQLPLP SAQETQKFCE QVHAAIKAFI AVYYLLPKDQ GITLRKLVRG
     ATLDIVDGMA QLMEVLSITP TQSPENNELI SYNSVWVACQ QMPHIPRDNK AAALLMLTKN
     VDFVKDAHEE MERAVEECDP YSGLLNDTEE NNSDNHNDED DVLGFPSNQD LYWSEDDQEL
     IIPCLALVRA SKACLKKIRI LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
     HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI KELTQSELEL