ID   CCDB1_RAT               Reviewed;         355 AA.
AC   Q5BK06;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cyclin-D1-binding protein 1;
GN   Name=Ccndbp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   INDUCTION.
RX   PubMed=10915743; DOI=10.1053/jhep.2000.9092;
RA   Terai S., Aoki H., Thorgeirsson S.S.;
RT   "Human homologue of maid: a dominant inhibitory helix-loop-helix protein
RT   associated with liver-specific gene expression.";
RL   Hepatology 32:357-366(2000).
CC   -!- FUNCTION: May negatively regulate cell cycle progression. May act at
CC       least in part via inhibition of the cyclin-D1/CDK4 complex, thereby
CC       preventing phosphorylation of RB1 and blocking E2F-dependent
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5,
CC       RPLP0, SIRT6, SYF2 and TCF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Expression is induced by partial hepatectomy.
CC       {ECO:0000269|PubMed:10915743}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCNDBP1 family. {ECO:0000305}.
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DR   EMBL; BC091256; AAH91256.1; -; mRNA.
DR   RefSeq; NP_001013222.1; NM_001013204.1.
DR   AlphaFoldDB; Q5BK06; -.
DR   SMR; Q5BK06; -.
DR   STRING; 10116.ENSRNOP00000015472; -.
DR   PaxDb; Q5BK06; -.
DR   PRIDE; Q5BK06; -.
DR   GeneID; 362201; -.
DR   KEGG; rno:362201; -.
DR   UCSC; RGD:1304669; rat.
DR   CTD; 23582; -.
DR   RGD; 1304669; Ccndbp1.
DR   eggNOG; ENOG502SGCW; Eukaryota.
DR   HOGENOM; CLU_067580_0_0_1; -.
DR   InParanoid; Q5BK06; -.
DR   OrthoDB; 1249310at2759; -.
DR   PhylomeDB; Q5BK06; -.
DR   TreeFam; TF336444; -.
DR   PRO; PR:Q5BK06; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q5BK06; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR026907; CCNDBP1.
DR   PANTHER; PTHR15492; PTHR15492; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
FT   CHAIN           2..355
FT                   /note="Cyclin-D1-binding protein 1"
FT                   /id="PRO_0000323376"
FT   REGION          2..205
FT                   /note="Required for interaction with CCND1"
FT                   /evidence="ECO:0000250"
FT   REGION          2..187
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   REGION          2..181
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          147..355
FT                   /note="Interaction with TCF3"
FT                   /evidence="ECO:0000250"
FT   REGION          203..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..355
FT                   /note="Interaction with RPLP0"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        205..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O95273"
SQ   SEQUENCE   355 AA;  39066 MW;  37C12D70CCAC6B55 CRC64;
     MASSTTPVSF LAPPLEQLRH LAEELRSLLP RVRVGEAQET AEEFNREMFW RRLNEAAMKV
     SGEATVLTTL FSKIPSPSPQ ETQRICEQVH IATEEVIAAY YTFPKDQGIT LRKLVRNAVL
     DIVDGTAQLL DALLAAPSQS PENGDLISCN SVSVACQQVA EIPKDNKAAA LLMLTKSVDL
     VKDAHEEMEQ AVEECDPYCG LLDDSEDNSD SHHNEDGVGL PSNRDSYWSE EDQALITPCL
     ALVRASRASL KKIRILVAEN GRKDQVAQLD DIVDISDEIS PSVDDLVLSV YPPVCHLTVR
     ITSAKLVSVL IKALEITKAS HVSPQPGDSW IPLLINAVDH CMDRIKELTQ RAVEL