ID   CCDC3_HUMAN             Reviewed;         270 AA.
AC   Q9BQI4; Q5VYV8; Q5VYV9;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Coiled-coil domain-containing protein 3;
DE   AltName: Full=Fat/vessel-derived secretory protein;
DE            Short=Favine;
DE   Flags: Precursor;
GN   Name=CCDC3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Amygdala;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY, AND INDUCTION BY PIOGLITAZONE.
RX   PubMed=20043878; DOI=10.1016/j.bbrc.2009.12.142;
RA   Kobayashi S., Fukuhara A., Taguchi T., Matsuda M., Tochino Y., Otsuki M.,
RA   Shimomura I.;
RT   "Identification of a new secretory factor, CCDC3/Favine, in adipocytes and
RT   endothelial cells.";
RL   Biochem. Biophys. Res. Commun. 392:29-35(2010).
RN   [6]
RP   FUNCTION.
RX   PubMed=25193116; DOI=10.1016/j.cellsig.2014.08.025;
RA   Azad A.K., Chakrabarti S., Xu Z., Davidge S.T., Fu Y.;
RT   "Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-
RT   alpha/nuclear factor kappaB-induced endothelial inflammation.";
RL   Cell. Signal. 26:2793-2800(2014).
CC   -!- FUNCTION: Negatively regulates TNF-alpha-induced pro-inflammatory
CC       response in endothelial cells (ECs) via inhibition of TNF-alpha-induced
CC       NF-kappaB activation in ECs (PubMed:25193116). Positively regulates
CC       lipid accumulation in adipose cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q9D6Y1, ECO:0000269|PubMed:25193116}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9D6Y1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D6Y1}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BQI4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BQI4-2; Sequence=VSP_054551;
CC   -!- TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells
CC       (HUVEC), and at lower levels in aortic smooth muscle cells (HASMC).
CC       {ECO:0000269|PubMed:20043878}.
CC   -!- INDUCTION: Up-regulated by pioglitazone and down-regulated by TNF in
CC       HUVEC. {ECO:0000269|PubMed:20043878}.
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DR   EMBL; AL136562; CAB66497.1; -; mRNA.
DR   EMBL; AK095792; BAG53129.1; -; mRNA.
DR   EMBL; AL355355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL596124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC051334; AAH51334.1; -; mRNA.
DR   CCDS; CCDS60484.1; -. [Q9BQI4-2]
DR   CCDS; CCDS7093.1; -. [Q9BQI4-1]
DR   RefSeq; NP_001269587.1; NM_001282658.1. [Q9BQI4-2]
DR   RefSeq; NP_113643.1; NM_031455.3. [Q9BQI4-1]
DR   AlphaFoldDB; Q9BQI4; -.
DR   SMR; Q9BQI4; -.
DR   STRING; 9606.ENSP00000368102; -.
DR   GlyGen; Q9BQI4; 1 site.
DR   PhosphoSitePlus; Q9BQI4; -.
DR   BioMuta; CCDC3; -.
DR   DMDM; 50400629; -.
DR   MassIVE; Q9BQI4; -.
DR   PaxDb; Q9BQI4; -.
DR   PeptideAtlas; Q9BQI4; -.
DR   PRIDE; Q9BQI4; -.
DR   ProteomicsDB; 65653; -.
DR   ProteomicsDB; 78684; -. [Q9BQI4-1]
DR   Antibodypedia; 55471; 95 antibodies from 23 providers.
DR   DNASU; 83643; -.
DR   Ensembl; ENST00000378825.5; ENSP00000368102.3; ENSG00000151468.11. [Q9BQI4-1]
DR   Ensembl; ENST00000378839.1; ENSP00000368116.1; ENSG00000151468.11. [Q9BQI4-2]
DR   GeneID; 83643; -.
DR   KEGG; hsa:83643; -.
DR   MANE-Select; ENST00000378825.5; ENSP00000368102.3; NM_031455.4; NP_113643.1.
DR   UCSC; uc001ilq.2; human. [Q9BQI4-1]
DR   CTD; 83643; -.
DR   DisGeNET; 83643; -.
DR   GeneCards; CCDC3; -.
DR   HGNC; HGNC:23813; CCDC3.
DR   HPA; ENSG00000151468; Tissue enhanced (skin).
DR   neXtProt; NX_Q9BQI4; -.
DR   OpenTargets; ENSG00000151468; -.
DR   PharmGKB; PA134863738; -.
DR   VEuPathDB; HostDB:ENSG00000151468; -.
DR   eggNOG; ENOG502QPN3; Eukaryota.
DR   GeneTree; ENSGT00390000014429; -.
DR   HOGENOM; CLU_085750_1_0_1; -.
DR   InParanoid; Q9BQI4; -.
DR   OMA; QDYAYFF; -.
DR   OrthoDB; 1381750at2759; -.
DR   PhylomeDB; Q9BQI4; -.
DR   TreeFam; TF331410; -.
DR   PathwayCommons; Q9BQI4; -.
DR   BioGRID-ORCS; 83643; 12 hits in 1089 CRISPR screens.
DR   ChiTaRS; CCDC3; human.
DR   GeneWiki; CCDC3; -.
DR   GenomeRNAi; 83643; -.
DR   Pharos; Q9BQI4; Tbio.
DR   PRO; PR:Q9BQI4; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9BQI4; protein.
DR   Bgee; ENSG00000151468; Expressed in saphenous vein and 169 other tissues.
DR   Genevisible; Q9BQI4; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR   GO; GO:0005576; C:extracellular region; IDA:GO_Central.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:GO_Central.
DR   GO; GO:0051055; P:negative regulation of lipid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045833; P:negative regulation of lipid metabolic process; IDA:GO_Central.
DR   GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IMP:UniProtKB.
DR   GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR040311; CCDC3.
DR   PANTHER; PTHR31663; PTHR31663; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250|UniProtKB:Q9D6Y1"
FT   CHAIN           22..270
FT                   /note="Coiled-coil domain-containing protein 3"
FT                   /id="PRO_0000020862"
FT   COILED          188..251
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..125
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_054551"
SQ   SEQUENCE   270 AA;  30731 MW;  BBC768A39B449FBB CRC64;
     MLRQLLLAAL CLAGPPAPAR ACQLPSEWRP LSEGCRAELA ETIVYARVLA LHPEAPGLYN
     HLPWQYHAGQ GGLFYSAEVE MLCDQAWGSM LEVPAGSRLN LTGLGYFSCH SHTVVQDYSY
     FFFLRMDENY NLLPHGVNFQ DAIFPDTQEN RRMFSSLFQF SNCSQGQQLA TFSSDWEIQE
     DSRLMCSSVQ KALFEEEDHV KKLQQKVATL EKRNRQLRER VKKVKRSLRQ ARKKGRHLEL
     ANQKLSEKLA AGALPHINAR GPVRPPYLRG