CCDC7_MACFA
ID CCDC7_MACFA Reviewed; 1394 AA.
AC Q95J40; Q8WNU5;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 08-JUN-2016, sequence version 3.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Coiled-coil domain-containing protein 7;
GN Name=CCDC7; ORFNames=QtsA-13406, QtsA-13472;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- FUNCTION: May play a role in tumorigenesis.
CC {ECO:0000250|UniProtKB:Q9D541}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95J40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95J40-2; Sequence=VSP_058372, VSP_058373, VSP_058374;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB63006.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAB63036.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAB84025.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};
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DR EMBL; AQIA01070568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01070575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB066550; BAB84025.1; ALT_SEQ; mRNA.
DR EMBL; AB070061; BAB63006.1; ALT_SEQ; mRNA.
DR EMBL; AB070091; BAB63036.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q95J40; -.
DR SMR; Q95J40; -.
DR STRING; 9541.XP_005564984.1; -.
DR eggNOG; ENOG502S48H; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR InterPro; IPR029272; CCDC7.
DR PANTHER; PTHR22035; PTHR22035; 3.
DR Pfam; PF15368; BioT2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1394
FT /note="Coiled-coil domain-containing protein 7"
FT /id="PRO_0000089400"
FT REGION 345..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 308..340
FT /evidence="ECO:0000255"
FT COILED 383..421
FT /evidence="ECO:0000255"
FT COMPBIAS 359..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 153..168
FT /note="VCILHYFFFCPSFVFL -> ILESLF (in isoform 2)"
FT /id="VSP_058372"
FT VAR_SEQ 181..190
FT /note="ISKDQTLLQA -> SLQNLAKQSL (in isoform 2)"
FT /id="VSP_058373"
FT VAR_SEQ 191..1394
FT /note="Missing (in isoform 2)"
FT /id="VSP_058374"
FT CONFLICT 87
FT /note="I -> V (in Ref. 2; BAB63006/BAB63036)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1394 AA; 158239 MW; 72B6DA1F68534C0F CRC64;
MKPVKHLLTT SNKSATLPAL TSKKGLHNLP LSPKLKEKHN AKLIHDKIEP MVLRSPPTGE
SIVRYALPIP SSKTKNLLPG DEMIGKIIKH LKMVVSTLEE TYGHCDQNGE EPFVKRENEE
LSLSIGDDMN SFLTCCSQFA TQLETALKEE QNVCILHYFF FCPSFVFLKW FQWQVNQMEE
ISKDQTLLQA EPPEPDKTVT LSIAQIVRLL QRFEELKNRL KQRSKSSWKV MLSKTMDEEN
RPEAVKSCEA VAQKIEEFIE AHSTDEFKGV SATEPQTAHS MTNRFNTMLK VFENQANMLE
RAVNDQVLLD AEYKQIQRDF ELLSEEKLVL ENELQKLKDT EKIKSTNNRT KKAAKTVKKK
DKGKSEDSEK KMSSEKEFKI KDLDQVQKVA RLEIENKVLQ EQLKQALQEA EKAKHQLNYF
LSQERKLLKS EGKTETTMRV GNSQTEVKGE DSKTIPLEKE TGKSLVSDSG GQKTSDKIQE
YPQITAQSGR LIEKSSEKKR SSPAISDLSQ ILKSQDESAF LESSNEVSVA ENQSNKSPSE
TRDESLTTVS SSKEVQDSLS VGTLAQKNET VMSPFILPPV LTESKKADVS EEQLQKKTEE
QTYQAPEKSQ AYSEVPDENL MVENKDSVTK VQVEQMKQTT SSMERREATL TTPQSPEDVV
LVSRSQSETK NLEATGNESF HSHNDVPEEN LMLEQDTKSK TEVEVKKQKS FQDNQLNTHN
EVPNERLIVE HQESMSKTKL QVKKQETSTE QPLTTHDKEP DENLTLGHQD SMSKSEMQVK
EQSTLKGQRI TTHEEEPGKN LALEHQDSLS KLEMQIKKNE KLPREKRHST HGEESSENPM
LKHQDAVSKI QVQLEKQETS EGGRSIPDKN SMFVHQDSVS KLQMQEKKKV TPGRERRNTH
IVVPNENVVS VHQDSKSKLQ MQEKKQINPG VEKHKTFPFE IQKKDISLEH LLPEEKVLLS
RRESQTKKLQ AKVTSRKITN EAASELPNTA ENLPAVYPSI SDLIIRLDLN KVVETDIESL
RGALGRRLLN DEFKTQPKSF PGSEIEQLTD AFGRDILKDE FKTRSKSLPE TDERLRRATE
RGTINNAMKT QLKRKSHPET GLKHLKGVNE KDIIKDLINI QSKRHAETDK EHLADAIGRG
IIKGSINAQL KGHQETDKNF FAYAIGRGVR KESIKTQLKS HPETDKEFLA DAIGRGIIIG
PIIRQLKSHQ ETDKQLLKDA IGRDIIKGPI NAQLKSHQET DVEPLTNAIG SSKTIGEIKT
QLRTHYDVNL FKNKDMSIQR QEGIFNRSIT PSKFPTKVIN LSPFENKEET YEYSSPYAIA
PSKAVYRTYR ASSSFSKDIH LPLLNQLHSG HSKVVTLNQK TIEFTLPSVT NTIGKPAYKV
LHAAARKSVP HPYF
