CCDC7_MOUSE
ID CCDC7_MOUSE Reviewed; 371 AA.
AC Q9D541; D3YY17;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Coiled-coil domain-containing protein 7;
DE AltName: Full=Protein BIOT2;
GN Name=Ccdc7; Synonyms=Biot2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=19277478; DOI=10.2478/s11658-009-0004-6;
RA Wang C.T., Zhang P., Wang Y.S., Ruan X.Z., Li Z.Y., Peng F., Yang H.S.,
RA Wei Y.Q.;
RT "RNA interference against Biot2, a novel mouse testis-specific gene,
RT inhibits the growth of tumor cells.";
RL Cell. Mol. Biol. Lett. 14:363-376(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in tumorigenesis.
CC {ECO:0000269|PubMed:19277478}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the testes. Abundantly
CC expressed in mouse cancer cell line derived from epithelial cells.
CC {ECO:0000269|PubMed:19277478}.
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DR EMBL; AY854152; AAX47309.1; -; mRNA.
DR EMBL; AK015811; BAB29987.1; -; mRNA.
DR EMBL; AC104928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC148114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466525; EDL11834.1; -; Genomic_DNA.
DR CCDS; CCDS40524.1; -.
DR RefSeq; NP_001183970.1; NM_001197041.1.
DR RefSeq; NP_083337.1; NM_029061.3.
DR AlphaFoldDB; Q9D541; -.
DR SMR; Q9D541; -.
DR STRING; 10090.ENSMUSP00000092780; -.
DR iPTMnet; Q9D541; -.
DR PhosphoSitePlus; Q9D541; -.
DR PaxDb; Q9D541; -.
DR PRIDE; Q9D541; -.
DR DNASU; 74703; -.
DR Ensembl; ENSMUST00000095158; ENSMUSP00000092780; ENSMUSG00000025808.
DR GeneID; 74703; -.
DR KEGG; mmu:74703; -.
DR UCSC; uc009nzy.2; mouse.
DR CTD; 74703; -.
DR MGI; MGI:1921953; Ccdc7.
DR VEuPathDB; HostDB:ENSMUSG00000025808; -.
DR eggNOG; ENOG502S48H; Eukaryota.
DR GeneTree; ENSGT00390000009751; -.
DR InParanoid; Q9D541; -.
DR OrthoDB; 1514586at2759; -.
DR PhylomeDB; Q9D541; -.
DR TreeFam; TF337205; -.
DR BioGRID-ORCS; 74703; 2 hits in 40 CRISPR screens.
DR ChiTaRS; Ccdc7a; mouse.
DR PRO; PR:Q9D541; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D541; protein.
DR Bgee; ENSMUSG00000025808; Expressed in spermatid and 37 other tissues.
DR ExpressionAtlas; Q9D541; baseline and differential.
DR Genevisible; Q9D541; MM.
DR InterPro; IPR029272; CCDC7.
DR PANTHER; PTHR22035; PTHR22035; 1.
DR Pfam; PF15368; BioT2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..371
FT /note="Coiled-coil domain-containing protein 7"
FT /id="PRO_0000419668"
FT REGION 21..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 277..331
FT /evidence="ECO:0000255"
FT COMPBIAS 29..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 42515 MW; B0DADD5BBE21F556 CRC64;
MKCAKHPSTI SMKLTSVPEL PYKKGLLNSS PKPKEKHNAK SKYGKNESMV LRSPPTGESI
VRFALPIPLS KTKDKISADE MVRRITTNLK MVVSNLEDTY GACYDNGEKA AEKSEAEGLS
IGDDVSSFLL CCSQFTSQLE EAVKEECGAL ESLYKWFQQQ VNQMEEISKD QSNLEELQSD
GKTASLNIVQ IAKLARKFED FKSRLKTRKE VMQTKNEDKE IMAETLKHYG LMEKQIEEFI
TSHSALESQT ETESQSGTPS VTTRMARMIK IFENQSTMLE KALNDQQTIE SKYKQLETDF
QMLIMEKTLL EAEIRRLREI ERVKSAAKEE QTKKSGKSEK KKFKEKEKYD MKICYLFIPQ
LVKMYLNHGL F
