CCDCX_DROME
ID CCDCX_DROME Reviewed; 1234 AA.
AC Q7KW14; O46062; O76897; O76919; Q8MR25; Q95R31; Q9W566;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Coiled-coil domain-containing protein CG32809;
GN ORFNames=CG32809;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF45655.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF45655.2}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:CAA19834.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R {ECO:0000269|PubMed:10731137};
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL27638.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 495-1234 (ISOFORM D), AND RNA EDITING OF POSITION
RP 179.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL27638.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569}, and
RC Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP RNA EDITING OF POSITION 179.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=D {ECO:0000269|PubMed:10731132};
CC IsoId=Q7KW14-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=Q7KW14-2; Sequence=VSP_052617, VSP_052618;
CC -!- RNA EDITING: Modified_positions=179 {ECO:0000269|PubMed:12537569,
CC ECO:0000269|PubMed:17018572}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:17018572};
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52678.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA16808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA19735.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA19834.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAF45655.2; -; Genomic_DNA.
DR EMBL; AE014298; AAF45659.3; -; Genomic_DNA.
DR EMBL; AL021726; CAA16808.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL031025; CAA19834.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL030993; CAA19735.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY061827; AAL27638.1; -; mRNA.
DR EMBL; AY122166; AAM52678.1; ALT_INIT; mRNA.
DR RefSeq; NP_569934.2; NM_130578.3. [Q7KW14-1]
DR RefSeq; NP_726755.1; NM_166899.2. [Q7KW14-2]
DR AlphaFoldDB; Q7KW14; -.
DR SMR; Q7KW14; -.
DR BioGRID; 57672; 19.
DR IntAct; Q7KW14; 6.
DR STRING; 7227.FBpp0300642; -.
DR PaxDb; Q7KW14; -.
DR DNASU; 31121; -.
DR EnsemblMetazoa; FBtr0089814; FBpp0088755; FBgn0023531. [Q7KW14-2]
DR EnsemblMetazoa; FBtr0089815; FBpp0088756; FBgn0023531. [Q7KW14-1]
DR GeneID; 31121; -.
DR KEGG; dme:Dmel_CG32809; -.
DR UCSC; CG32809-RB; d. melanogaster. [Q7KW14-1]
DR FlyBase; FBgn0023531; CG32809.
DR VEuPathDB; VectorBase:FBgn0023531; -.
DR eggNOG; ENOG502QUBF; Eukaryota.
DR GeneTree; ENSGT00940000169091; -.
DR InParanoid; Q7KW14; -.
DR PhylomeDB; Q7KW14; -.
DR BioGRID-ORCS; 31121; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31121; -.
DR PRO; PR:Q7KW14; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0023531; Expressed in brain and 24 other tissues.
DR ExpressionAtlas; Q7KW14; baseline and differential.
DR Genevisible; Q7KW14; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR022782; AIP3-like_C.
DR Pfam; PF03915; AIP3; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; RNA editing.
FT CHAIN 1..1234
FT /note="Coiled-coil domain-containing protein CG32809"
FT /id="PRO_0000311725"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 412..436
FT /evidence="ECO:0000255"
FT COILED 565..594
FT /evidence="ECO:0000255"
FT COILED 630..666
FT /evidence="ECO:0000255"
FT COILED 1077..1105
FT /evidence="ECO:0000255"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 780..794
FT /note="PIPTPRMGSFALSGG -> FNWRWSSNFKEAITE (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052617"
FT VAR_SEQ 795..1234
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10731132,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_052618"
FT VARIANT 179
FT /note="K -> R (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:17018572"
SQ SEQUENCE 1234 AA; 134461 MW; F242447DD69AB0A8 CRC64;
MLIRWKSKDK SASSNQSVGG SSSSSSKKKR KGREGEEDWQ NEAKSGRLPS NEQGGDERRR
AMRRDDPRRH TLGGDMLVYG SQHPHAHQMA PQQQRAMDLE MSTRAQKNKK NQPMRGYAPV
NQGPLFDDDP GIMSEVETAS TGFRRGGKQR SSLPVVRTPS KTLERPLGLV FLQYRSETKR
ALLPNEITSI DTVRALFVRS FPRQLTMSYL EGPNVKIYIH DASKDMFYEL EDVRSHLREI
RDRSVLRLFE STEVAAPPQI LPGGPGIPQP LPQAQANWDQ DQSYFSEPEF DSDYKHQHIH
KSKIGKQPAP YYVGSSQTLP RGMYSSERNK VSMDGYTSSP ERSSRGNYEE PYYSQYGTRG
AVVAPIIDEE QSDGTMTEDQ YALYGIKVGP GPNRLTHRGN QIYDPTRPED LHRIRVEHME
RQLANLTGLV QKALVNQNPQ IAPLAVPTLD PNYLVVPSQM QANGSGDELY IREKAPKLGK
NSCQKSVSFE KSVSFSDDIQ GIPKSHNPLH AAETKPTKPA IKSSTLPRTS SQERDRLKPP
PPPKPIVLAQ TAHPNYRADI ALAPEVYNHL RGLQKKAKDL RMEVRTLRRL SQAQAVAVRE
DIKGTFMRIR ATLLASSGSF WDHQGDQDAT RISREEELYK QEVIRLEKDL SDLEGSVENL
RGEVINRRTR VNMTAVEDMA LVLSRASKTV AELKLKFPSL SNGLRCILSN EMEKVVREEK
FLKEEPDRLE SALRRCKKLT GTLVTLKRLA SVQEQRLPPN EPTISEETPR SADISAPDKP
IPTPRMGSFA LSGGLAPENA LDALLDELKT FSKPIAQQQQ QQQQQQQQQQ QQHQHQQLYE
IRPEDSASDE SAQAAVQSTV TTQISQARLY TEASVNVQQA TTGSMVIAVA SGTVSAQAQA
QRGVLTHQQS QSQAQLMVHT NMGSLRRLHS YPSESDGELP GPPPTGPRAS ETSSSTSLAN
GGSSSKPPVP ERNAELITKV GHKRIPPPPP PRTSSRSPLA SPTSPNVPPN QAAAATVNLI
PNSNSNASAN ANANANSNAT GNKGIVGETT SVVSGDTSSG DNSSGNESGN DHVQRQVALE
MRHQELLKKQ KMLQEQYQRL QQMSKLPSVD VASSSSSSAQ DIASGSNTLR KLGSETNIQQ
KIAALSLACE TSGAAAAAAA AAAAAATNGG VVASDATSGA IGGGGGAGAA GAAGASAAAA
HSNSNSNSNL NLNLNSQHQT ATTTTKQLYE TEIL
