ID   CCG1_BOVIN              Reviewed;         223 AA.
AC   Q08DE1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Voltage-dependent calcium channel gamma-1 subunit;
DE   AltName: Full=Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma;
GN   Name=CACNG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of the voltage-gated calcium channel that
CC       gives rise to L-type calcium currents in skeletal muscle. Regulates
CC       channel inactivation kinetics. {ECO:0000250|UniProtKB:P19518}.
CC   -!- SUBUNIT: Component of a calcium channel complex consisting of a pore-
CC       forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or
CC       CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta,
CC       gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either
CC       CACNB1 or CACNB2. {ECO:0000250|UniProtKB:P19518}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC       {ECO:0000250|UniProtKB:P19518}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P19518}.
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:P19518}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC123800; AAI23801.1; -; mRNA.
DR   RefSeq; NP_001073806.1; NM_001080337.1.
DR   AlphaFoldDB; Q08DE1; -.
DR   SMR; Q08DE1; -.
DR   STRING; 9913.ENSBTAP00000009930; -.
DR   PaxDb; Q08DE1; -.
DR   Ensembl; ENSBTAT00000009930; ENSBTAP00000009930; ENSBTAG00000007547.
DR   GeneID; 781184; -.
DR   KEGG; bta:781184; -.
DR   CTD; 786; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007547; -.
DR   VGNC; VGNC:26686; CACNG1.
DR   eggNOG; ENOG502QT5N; Eukaryota.
DR   GeneTree; ENSGT00390000007786; -.
DR   HOGENOM; CLU_093876_0_0_1; -.
DR   InParanoid; Q08DE1; -.
DR   OMA; WIEYYYG; -.
DR   OrthoDB; 1261253at2759; -.
DR   TreeFam; TF331651; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000007547; Expressed in laryngeal cartilage and 31 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR   GO; GO:0042383; C:sarcolemma; ISS:UniProtKB.
DR   GO; GO:0030315; C:T-tubule; ISS:UniProtKB.
DR   GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:UniProtKB.
DR   GO; GO:0070296; P:sarcoplasmic reticulum calcium ion transport; IEA:Ensembl.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR005421; VDCC_g1su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   Pfam; PF13903; Claudin_2; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01601; VDCCGAMMA1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Cell membrane; Disulfide bond;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..223
FT                   /note="Voltage-dependent calcium channel gamma-1 subunit"
FT                   /id="PRO_0000261025"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        11..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P19518"
FT   TOPO_DOM        30..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P19518"
FT   TOPO_DOM        131..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P19518"
FT   TOPO_DOM        157..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        181..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P19518"
FT   TOPO_DOM        206..223
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        57..81
FT                   /evidence="ECO:0000250|UniProtKB:P19518"
SQ   SEQUENCE   223 AA;  24694 MW;  198E11649A515AA9 CRC64;
     MSQTKTLKVR VALLCILVGI VLALVAVVTD HWAVLSPHVE HHNSTCEAAH FGLWRICTKR
     IFVGDKERSC GPITLPGEKN CSYFRHFNPG ESSEIFEVTT QKEYSISAAA IAIFSLGFII
     VGTLCALLSF RKKRDYLLRP ASMFYIFAGL CLSVSAEVMR QSVQRMVDSE HTAWIAHSLA
     WSFICACVAA ALLLVGGLAL LLLALPRMPR DPWESCMDAE PEH