CCG3_MACFA
ID CCG3_MACFA Reviewed; 315 AA.
AC Q4R589;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Voltage-dependent calcium channel gamma-3 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-3;
DE Short=TARP gamma-3;
GN Name=CACNG3; ORFNames=QccE-13852;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the trafficking to the somatodendritic compartment
CC and gating properties of AMPA-selective glutamate receptors (AMPARs).
CC Promotes their targeting to the cell membrane and synapses and
CC modulates their gating properties by slowing their rates of activation,
CC deactivation and desensitization. Does not show subunit-specific AMPA
CC receptor regulation and regulates all AMPAR subunits. Thought to
CC stabilize the calcium channel in an inactivated (closed) state.
CC {ECO:0000250|UniProtKB:Q8VHX0}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5,
CC CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1
CC with the adaptor protein complex 4 (AP-4) to target GRIA1 to the
CC somatodendritic compartment of neurons. {ECO:0000250|UniProtKB:Q8VHX0,
CC ECO:0000250|UniProtKB:Q9JJV5}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}. Note=Displays a somatodendritic localization and
CC is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AB169655; BAE01736.1; -; mRNA.
DR RefSeq; NP_001270151.1; NM_001283222.1.
DR AlphaFoldDB; Q4R589; -.
DR SMR; Q4R589; -.
DR STRING; 9541.XP_005591531.1; -.
DR Ensembl; ENSMFAT00000012440; ENSMFAP00000038185; ENSMFAG00000038460.
DR GeneID; 101926678; -.
DR CTD; 10368; -.
DR eggNOG; ENOG502QVF5; Eukaryota.
DR GeneTree; ENSGT01050000244893; -.
DR OrthoDB; 1117127at2759; -.
DR Proteomes; UP000233100; Chromosome 20.
DR Bgee; ENSMFAG00000038460; Expressed in temporal lobe and 1 other tissue.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0036477; C:somatodendritic compartment; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0006605; P:protein targeting; ISS:UniProtKB.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008368; VDCC_gsu.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..315
FT /note="Voltage-dependent calcium channel gamma-3 subunit"
FT /id="PRO_0000226296"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VHX0"
SQ SEQUENCE 315 AA; 35549 MW; 5DCFB9FB44B5A2F4 CRC64;
MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH
SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL
CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY
FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST
EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
ESLHNNPANR RTTPV
