ID   CCG3_PONAB              Reviewed;         315 AA.
AC   Q5R5X2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Voltage-dependent calcium channel gamma-3 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit;
DE   AltName: Full=Transmembrane AMPAR regulatory protein gamma-3;
DE            Short=TARP gamma-3;
GN   Name=CACNG3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the trafficking to the somatodendritic compartment
CC       and gating properties of AMPA-selective glutamate receptors (AMPARs).
CC       Promotes their targeting to the cell membrane and synapses and
CC       modulates their gating properties by slowing their rates of activation,
CC       deactivation and desensitization. Does not show subunit-specific AMPA
CC       receptor regulation and regulates all AMPAR subunits. Thought to
CC       stabilize the calcium channel in an inactivated (closed) state.
CC       {ECO:0000250|UniProtKB:Q8VHX0}.
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC       for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC       with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5,
CC       CACNG7 and CACNG8 (By similarity). Interacts with AP4M1 and GRIA1;
CC       associates GRIA1 with the adaptor protein complex 4 (AP-4) to target
CC       GRIA1 to the somatodendritic compartment of neurons (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:Q8VHX0,
CC       ECO:0000250|UniProtKB:Q9JJV5}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}. Note=Displays a somatodendritic localization and
CC       is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR860729; CAH92844.1; -; mRNA.
DR   RefSeq; NP_001126660.1; NM_001133188.1.
DR   RefSeq; XP_009248835.1; XM_009250560.1.
DR   AlphaFoldDB; Q5R5X2; -.
DR   SMR; Q5R5X2; -.
DR   STRING; 9601.ENSPPYP00000008140; -.
DR   Ensembl; ENSPPYT00000050903; ENSPPYP00000029392; ENSPPYG00000007200.
DR   GeneID; 100173660; -.
DR   GeneID; 100189826; -.
DR   CTD; 10368; -.
DR   eggNOG; ENOG502QVF5; Eukaryota.
DR   GeneTree; ENSGT01050000244893; -.
DR   HOGENOM; CLU_053704_0_1_1; -.
DR   InParanoid; Q5R5X2; -.
DR   OMA; TCCTEGI; -.
DR   OrthoDB; 1117127at2759; -.
DR   TreeFam; TF327980; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0036477; C:somatodendritic compartment; ISS:UniProtKB.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0006605; P:protein targeting; ISS:UniProtKB.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008368; VDCC_gsu.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..315
FT                   /note="Voltage-dependent calcium channel gamma-3 subunit"
FT                   /id="PRO_0000261027"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         248
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VHX0"
SQ   SEQUENCE   315 AA;  35549 MW;  5DCFB9FB44B5A2F4 CRC64;
     MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH
     SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL
     CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY
     FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST
     EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
     ESLHNNPANR RTTPV