CCG4_NEUCR
ID CCG4_NEUCR Reviewed; 299 AA.
AC Q01301; Q01298; Q7RW13; Q96UP0;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Clock-controlled pheromone ccg-4;
DE Contains:
DE RecName: Full=Pheromone ccg-4;
DE Flags: Precursor;
GN Name=ccg-4; Synonyms=ppg1; ORFNames=NCU02500;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1] {ECO:0000312|EMBL:CAC86411.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=11738813; DOI=10.1016/s0378-1119(01)00786-7;
RA Poeggeler S., Kueck U.;
RT "Identification of transcriptionally expressed pheromone receptor genes in
RT filamentous fungi.";
RL Gene 280:9-17(2001).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAL23837.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhu H., Lai H., Kupfer D.M., Bell-Pedersen D., Loros J.J., Dunlap J.C.,
RA Roe B.A.;
RT "Neurospora crassa cDNA homolog of the pheromone precursor gene, ppg-1,
RT from Sordaria macrospora.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION, FUNCTION, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=FRQ7 / 695-425 / FGSC 4898;
RX PubMed=12139624; DOI=10.1046/j.1365-2958.2002.03052.x;
RA Bobrowicz P., Pawlak R., Correa A., Bell-Pedersen D., Ebbole D.J.;
RT "The Neurospora crassa pheromone precursor genes are regulated by the
RT mating type locus and the circadian clock.";
RL Mol. Microbiol. 45:795-804(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [5] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-299, FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC STRAIN=FRQ7 / 695-425 / FGSC 4898;
RX PubMed=8917550; DOI=10.1073/pnas.93.23.13096;
RA Bell-Pedersen D., Shinohara M.L., Loros J.J., Dunlap J.C.;
RT "Circadian clock-controlled genes isolated from Neurospora crassa are late
RT night- to early morning-specific.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:13096-13101(1996).
CC -!- FUNCTION: Pheromone that is regulated by the circadian clock.
CC Expression is mating type specific and under the control of the mating
CC type locus. Involved in conidiation. {ECO:0000269|PubMed:12139624,
CC ECO:0000269|PubMed:8917550}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12139624}.
CC -!- DEVELOPMENTAL STAGE: During conidial development. Expressed with a 22
CC hours rhythm under the control of the circadian biological clock.
CC {ECO:0000269|PubMed:8917550}.
CC -!- INDUCTION: By light and circadian rhythms.
CC {ECO:0000269|PubMed:8917550}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA98468.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAA98469.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AJ313526; CAC86411.1; -; mRNA.
DR EMBL; AY037927; AAL23837.1; -; mRNA.
DR EMBL; AF088909; AAC64288.2; -; Genomic_DNA.
DR EMBL; CM002236; EAA35858.1; -; Genomic_DNA.
DR EMBL; U46085; AAA98468.1; ALT_INIT; mRNA.
DR EMBL; U46085; AAA98469.1; ALT_SEQ; mRNA.
DR PIR; T47209; T47209.
DR PIR; T47210; T47210.
DR RefSeq; XP_965094.1; XM_960001.3.
DR AlphaFoldDB; Q01301; -.
DR STRING; 5141.EFNCRP00000001973; -.
DR EnsemblFungi; EAA35858; EAA35858; NCU02500.
DR GeneID; 3881235; -.
DR KEGG; ncr:NCU02500; -.
DR VEuPathDB; FungiDB:NCU02500; -.
DR HOGENOM; CLU_075116_0_0_1; -.
DR InParanoid; Q01301; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0000772; F:mating pheromone activity; IDA:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; IDA:UniProtKB.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Pheromone; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..28
FT /note="Removed by dipeptidase"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020867"
FT PEPTIDE 29..39
FT /note="Pheromone ccg-4"
FT /id="PRO_0000020868"
FT PROPEP 44..117
FT /id="PRO_0000020869"
FT PROPEP 120..125
FT /note="Removed by dipeptidase"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020870"
FT PEPTIDE 126..136
FT /note="Pheromone ccg-4"
FT /id="PRO_0000020871"
FT PROPEP 140..143
FT /note="Removed by dipeptidase"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020872"
FT PEPTIDE 144..154
FT /note="Pheromone ccg-4"
FT /id="PRO_0000020873"
FT PROPEP 157..164
FT /note="Removed by dipeptidase"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020874"
FT PEPTIDE 165..175
FT /note="Pheromone ccg-4"
FT /id="PRO_0000020875"
FT PROPEP 179..192
FT /note="Removed by dipeptidase"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020876"
FT PEPTIDE 193..203
FT /note="Pheromone ccg-4"
FT /id="PRO_0000020877"
FT PROPEP 208..299
FT /evidence="ECO:0000305"
FT /id="PRO_0000020878"
FT CONFLICT 221
FT /note="A -> T (in Ref. 5; AAA98468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 33268 MW; 3EB6B64B38638E9A CRC64;
MKFTLPLVIF AAVASATPVA QPNAEAEAQW CRIHGQSCWK VKRVADAFAN AIQGMGGLPP
RDESGHQPAQ VAKRQVDELA GIIALTQEDV NAYYDSLSLQ EKFAPSTEEE KKTEKVAKRE
AEAEAQWCRI HGQSCWKKRE AEAQWCRIHG QSCWKRDALP EAEPQWCRIH GQSCWKKRDA
APEAAPEAEA NPQWCRIHGQ SCWKAKRAAE AVMTAIQSAE AESALLLRDT TFSPVDRVGK
RDPQVCNMRL HPKKVCWKRD ASPEAACNAP DGSCTKATRD LHAMYNVARA ILTAHSDEN
