CCG5_HUMAN
ID CCG5_HUMAN Reviewed; 275 AA.
AC Q9UF02; A8K2A6; Q547R3; Q8WXS7; Q9UHM3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Voltage-dependent calcium channel gamma-5 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-5 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-5;
DE Short=TARP gamma-5;
GN Name=CACNG5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=10613843; DOI=10.1101/gr.9.12.1204;
RA Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.;
RT "Identification of three novel Ca(2+) channel gamma subunit genes reveals
RT molecular diversification by tandem and chromosome duplication.";
RL Genome Res. 9:1204-1213(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C.,
RA Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT "The novel product of a five-exon stargazin-related gene abolishes CaV2.2
RT calcium channel expression.";
RL EMBO J. 21:1514-1523(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates the gating properties of AMPA-selective glutamate
CC receptors (AMPARs). Modulates their gating properties by accelerating
CC their rates of activation, deactivation and desensitization. Displays
CC subunit-specific AMPA receptor regulation. Shows specificity for GRIA1,
CC GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium
CC channel in an inactivated (closed) state (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4,
CC CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AF142621; AAF03089.1; -; Genomic_DNA.
DR EMBL; AF142618; AAF03089.1; JOINED; Genomic_DNA.
DR EMBL; AF142619; AAF03089.1; JOINED; Genomic_DNA.
DR EMBL; AF142620; AAF03089.1; JOINED; Genomic_DNA.
DR EMBL; AF148220; AAF00132.1; -; mRNA.
DR EMBL; AF361351; AAL50046.1; -; mRNA.
DR EMBL; AF458898; AAM00595.1; -; mRNA.
DR EMBL; AK290171; BAF82860.1; -; mRNA.
DR EMBL; BC101607; AAI01608.1; -; mRNA.
DR EMBL; BC101633; AAI01634.1; -; mRNA.
DR CCDS; CCDS11665.1; -.
DR RefSeq; NP_665810.1; NM_145811.2.
DR AlphaFoldDB; Q9UF02; -.
DR SMR; Q9UF02; -.
DR BioGRID; 117993; 56.
DR IntAct; Q9UF02; 39.
DR STRING; 9606.ENSP00000436836; -.
DR ChEMBL; CHEMBL2363032; -.
DR DrugBank; DB13746; Bioallethrin.
DR DrugBank; DB11148; Butamben.
DR DrugBank; DB00228; Enflurane.
DR DrugBank; DB00153; Ergocalciferol.
DR DrugBank; DB00421; Spironolactone.
DR iPTMnet; Q9UF02; -.
DR PhosphoSitePlus; Q9UF02; -.
DR BioMuta; CACNG5; -.
DR DMDM; 20532390; -.
DR PaxDb; Q9UF02; -.
DR PeptideAtlas; Q9UF02; -.
DR PRIDE; Q9UF02; -.
DR ProteomicsDB; 84162; -.
DR Antibodypedia; 31684; 101 antibodies from 30 providers.
DR DNASU; 27091; -.
DR Ensembl; ENST00000307139.4; ENSP00000303092.3; ENSG00000075429.9.
DR Ensembl; ENST00000533854.6; ENSP00000436836.1; ENSG00000075429.9.
DR GeneID; 27091; -.
DR KEGG; hsa:27091; -.
DR MANE-Select; ENST00000533854.6; ENSP00000436836.1; NM_145811.3; NP_665810.1.
DR UCSC; uc010wqi.3; human.
DR CTD; 27091; -.
DR DisGeNET; 27091; -.
DR GeneCards; CACNG5; -.
DR HGNC; HGNC:1409; CACNG5.
DR HPA; ENSG00000075429; Group enriched (brain, retina).
DR MIM; 606405; gene.
DR neXtProt; NX_Q9UF02; -.
DR OpenTargets; ENSG00000075429; -.
DR PharmGKB; PA26019; -.
DR VEuPathDB; HostDB:ENSG00000075429; -.
DR eggNOG; ENOG502QTQ7; Eukaryota.
DR GeneTree; ENSGT01050000244961; -.
DR HOGENOM; CLU_053704_1_1_1; -.
DR InParanoid; Q9UF02; -.
DR OMA; EEIYRPH; -.
DR OrthoDB; 1093662at2759; -.
DR PhylomeDB; Q9UF02; -.
DR TreeFam; TF327980; -.
DR PathwayCommons; Q9UF02; -.
DR SignaLink; Q9UF02; -.
DR BioGRID-ORCS; 27091; 13 hits in 1063 CRISPR screens.
DR ChiTaRS; CACNG5; human.
DR GenomeRNAi; 27091; -.
DR Pharos; Q9UF02; Tdark.
DR PRO; PR:Q9UF02; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9UF02; protein.
DR Bgee; ENSG00000075429; Expressed in anterior cingulate cortex and 28 other tissues.
DR ExpressionAtlas; Q9UF02; baseline and differential.
DR Genevisible; Q9UF02; HS.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098978; C:glutamatergic synapse; IMP:SynGO.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0015075; F:ion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; IMP:SynGO.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008369; VDCC_g5su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107:SF4; PTHR12107:SF4; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01793; VDCCGAMMA5.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Postsynaptic cell membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..275
FT /note="Voltage-dependent calcium channel gamma-5 subunit"
FT /id="PRO_0000164681"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 191..275
FT /note="SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQFLHPDAWVRGRS
FT PSDISSEASLQMNSNYPALLKCPDYDQMSSSPC -> VKPVTLSMDRLGLGTAPLSRGE
FT WGWGRRDIPQPFWTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHFPPHSSC
FT VLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 30903 MW; 889E04DAC036C2AE CRC64;
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI KMSLHSGLWR
VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILNNI
GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA
FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG
RSPSDISSEA SLQMNSNYPA LLKCPDYDQM SSSPC
