CCG5_MOUSE
ID CCG5_MOUSE Reviewed; 275 AA.
AC Q8VHW4;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Voltage-dependent calcium channel gamma-5 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-5 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-5;
DE Short=TARP gamma-5;
GN Name=Cacng5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18817736; DOI=10.1016/j.neuron.2008.07.034;
RA Kato A.S., Siuda E.R., Nisenbaum E.S., Bredt D.S.;
RT "AMPA receptor subunit-specific regulation by a distinct family of type II
RT TARPs.";
RL Neuron 59:986-996(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulates the gating properties of AMPA-selective glutamate
CC receptors (AMPARs). Modulates their gating properties by accelerating
CC their rates of activation, deactivation and desensitization. Displays
CC subunit-specific AMPA receptor regulation. Shows specificity for GRIA1,
CC GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium
CC channel in an inactivated (closed) state (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4,
CC CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Brain. Enriched in Bergman glia, as well as a
CC variety of neuronal populations including locus coeruleus, olfactory
CC bulb, lateral septal nucleus, interpeduncular nucleus, and the CA2 and
CC rostral/medial CA1 regions of hippocampus.
CC {ECO:0000269|PubMed:18817736}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF361347; AAL50042.1; -; mRNA.
DR CCDS; CCDS25572.1; -.
DR RefSeq; NP_001186230.1; NM_001199301.1.
DR RefSeq; NP_542375.1; NM_080644.3.
DR AlphaFoldDB; Q8VHW4; -.
DR SMR; Q8VHW4; -.
DR STRING; 10090.ENSMUSP00000047888; -.
DR TCDB; 8.A.16.2.4; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR iPTMnet; Q8VHW4; -.
DR PhosphoSitePlus; Q8VHW4; -.
DR PaxDb; Q8VHW4; -.
DR PRIDE; Q8VHW4; -.
DR ProteomicsDB; 265609; -.
DR Antibodypedia; 31684; 101 antibodies from 30 providers.
DR DNASU; 140723; -.
DR Ensembl; ENSMUST00000039071; ENSMUSP00000047888; ENSMUSG00000040373.
DR Ensembl; ENSMUST00000106742; ENSMUSP00000102353; ENSMUSG00000040373.
DR GeneID; 140723; -.
DR KEGG; mmu:140723; -.
DR UCSC; uc007mbb.1; mouse.
DR CTD; 27091; -.
DR MGI; MGI:2157946; Cacng5.
DR VEuPathDB; HostDB:ENSMUSG00000040373; -.
DR eggNOG; ENOG502QTQ7; Eukaryota.
DR GeneTree; ENSGT01050000244961; -.
DR HOGENOM; CLU_053704_1_1_1; -.
DR InParanoid; Q8VHW4; -.
DR OMA; EEIYRPH; -.
DR OrthoDB; 1093662at2759; -.
DR PhylomeDB; Q8VHW4; -.
DR TreeFam; TF327980; -.
DR BioGRID-ORCS; 140723; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Cacng5; mouse.
DR PRO; PR:Q8VHW4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VHW4; protein.
DR Bgee; ENSMUSG00000040373; Expressed in rostral migratory stream and 89 other tissues.
DR ExpressionAtlas; Q8VHW4; baseline and differential.
DR Genevisible; Q8VHW4; MM.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; ISO:MGI.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; ISO:MGI.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008369; VDCC_g5su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107:SF4; PTHR12107:SF4; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01793; VDCCGAMMA5.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Postsynaptic cell membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..275
FT /note="Voltage-dependent calcium channel gamma-5 subunit"
FT /id="PRO_0000164682"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 275 AA; 30894 MW; 37A01454A6CAC1CC CRC64;
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGI ILPQNQSTEV KMSLHSGLWR
VCFLAGEERG RCFTIEYVMP MNSQMTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILSNI
GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA
FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWIRG
RSPSDISSDA SLQMNSNYPA LLKCPDYDQM SSSPC
