CCG5_RAT
ID CCG5_RAT Reviewed; 275 AA.
AC Q8VHW8;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Voltage-dependent calcium channel gamma-5 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-5 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-5;
DE Short=TARP gamma-5;
GN Name=Cacng5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH GRIA1; GRIA2; GRIA3
RP AND GRIA4.
RX PubMed=18817736; DOI=10.1016/j.neuron.2008.07.034;
RA Kato A.S., Siuda E.R., Nisenbaum E.S., Bredt D.S.;
RT "AMPA receptor subunit-specific regulation by a distinct family of type II
RT TARPs.";
RL Neuron 59:986-996(2008).
RN [3]
RP FUNCTION, AND INTERACTION WITH GRIA1; GRIA2 AND GRIA4.
RX PubMed=19234459; DOI=10.1038/nn.2266;
RA Soto D., Coombs I.D., Renzi M., Zonouzi M., Farrant M., Cull-Candy S.G.;
RT "Selective regulation of long-form calcium-permeable AMPA receptors by an
RT atypical TARP, gamma-5.";
RL Nat. Neurosci. 12:277-285(2009).
RN [4]
RP ERRATUM OF PUBMED:19234459.
RX DOI=10.1038/nn0609-808c;
RA Soto D., Coombs I.D., Renzi M., Zonouzi M., Farrant M., Cull-Candy S.G.;
RL Nat. Neurosci. 12:808-808(2009).
RN [5]
RP SUBUNIT, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=19265014; DOI=10.1126/science.1167852;
RA Schwenk J., Harmel N., Zolles G., Bildl W., Kulik A., Heimrich B.,
RA Chisaka O., Jonas P., Schulte U., Fakler B., Kloecker N.;
RT "Functional proteomics identify cornichon proteins as auxiliary subunits of
RT AMPA receptors.";
RL Science 323:1313-1319(2009).
CC -!- FUNCTION: Regulates the gating properties of AMPA-selective glutamate
CC receptors (AMPARs). Modulates their gating properties by accelerating
CC their rates of activation, deactivation and desensitization. Displays
CC subunit-specific AMPA receptor regulation. Shows specificity for GRIA1,
CC GRIA4 and the long isoform of GRIA2. According to PubMed:18817736,
CC shows only specificity for GRIA2 and specifically to the form of GRIA2
CC for which a single amino acid in the pore region has been edited from a
CC glutamine to an arginine residue. Thought to stabilize the calcium
CC channel in an inactivated (closed) state. {ECO:0000269|PubMed:18817736,
CC ECO:0000269|PubMed:19234459}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4,
CC CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4.
CC {ECO:0000269|PubMed:18817736, ECO:0000269|PubMed:19234459,
CC ECO:0000269|PubMed:19265014}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Postsynaptic density membrane
CC {ECO:0000269|PubMed:18817736}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AF361342; AAL50037.1; -; mRNA.
DR RefSeq; NP_542424.1; NM_080693.1.
DR RefSeq; XP_017452463.1; XM_017596974.1.
DR AlphaFoldDB; Q8VHW8; -.
DR SMR; Q8VHW8; -.
DR STRING; 10116.ENSRNOP00000004578; -.
DR PaxDb; Q8VHW8; -.
DR PRIDE; Q8VHW8; -.
DR Ensembl; ENSRNOT00000004578; ENSRNOP00000004578; ENSRNOG00000003288.
DR GeneID; 140726; -.
DR KEGG; rno:140726; -.
DR UCSC; RGD:628805; rat.
DR CTD; 27091; -.
DR RGD; 628805; Cacng5.
DR eggNOG; ENOG502QTQ7; Eukaryota.
DR GeneTree; ENSGT01050000244961; -.
DR HOGENOM; CLU_053704_1_1_1; -.
DR InParanoid; Q8VHW8; -.
DR OMA; EEIYRPH; -.
DR OrthoDB; 1093662at2759; -.
DR PhylomeDB; Q8VHW8; -.
DR PRO; PR:Q8VHW8; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000003288; Expressed in adult mammalian kidney and 3 other tissues.
DR Genevisible; Q8VHW8; RN.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IDA:UniProtKB.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0014069; C:postsynaptic density; IDA:UniProtKB.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; IDA:UniProtKB.
DR GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; ISO:RGD.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008369; VDCC_g5su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107:SF4; PTHR12107:SF4; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01793; VDCCGAMMA5.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Postsynaptic cell membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..275
FT /note="Voltage-dependent calcium channel gamma-5 subunit"
FT /id="PRO_0000164683"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 275 AA; 30924 MW; 31177F24A99A34CC CRC64;
MSTCGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGI ILPQNQSTEV KMSLHSGLWR
VCFLAGEERG RCFTIEYVMP MNSQMTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILSNI
GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA
FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWIRG
RSPSDISSDA SLQMNSNYPA LLKCPDYDQM SSSPC
