CCG6_MOUSE
ID CCG6_MOUSE Reviewed; 260 AA.
AC Q8VHW3;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Voltage-dependent calcium channel gamma-6 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-6 subunit;
GN Name=Cacng6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP IDENTIFICATION IN A COMPLEX WITH CACNA1C, SUBUNIT, AND TISSUE SPECIFICITY.
RX PubMed=21127204; DOI=10.1096/fj.10-172353;
RA Yang L., Katchman A., Morrow J.P., Doshi D., Marx S.O.;
RT "Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.";
RL FASEB J. 25:928-936(2011).
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit.
CC {ECO:0000250|UniProtKB:Q9BXT2}.
CC -!- SUBUNIT: Interacts with CACNA1C (PubMed:21127204). Identified in a
CC complex with the L-type calcium channel subunits CACNA1C, CACNA2D1 and
CC either CACNB1 or CACNB2 (By similarity). {ECO:0000250|UniProtKB:Q9BXT2,
CC ECO:0000269|PubMed:21127204}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXT2};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXT2}.
CC -!- TISSUE SPECIFICITY: Detected in brain and heart (at protein level).
CC {ECO:0000269|PubMed:21127204}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF361348; AAL50043.1; -; mRNA.
DR CCDS; CCDS39726.1; -.
DR RefSeq; NP_573446.1; NM_133183.2.
DR AlphaFoldDB; Q8VHW3; -.
DR SMR; Q8VHW3; -.
DR STRING; 10090.ENSMUSP00000138622; -.
DR PhosphoSitePlus; Q8VHW3; -.
DR PaxDb; Q8VHW3; -.
DR PRIDE; Q8VHW3; -.
DR ProteomicsDB; 281422; -.
DR Antibodypedia; 32772; 120 antibodies from 19 providers.
DR DNASU; 54378; -.
DR Ensembl; ENSMUST00000183200; ENSMUSP00000138622; ENSMUSG00000078815.
DR GeneID; 54378; -.
DR KEGG; mmu:54378; -.
DR UCSC; uc009euy.1; mouse.
DR CTD; 59285; -.
DR MGI; MGI:1859168; Cacng6.
DR VEuPathDB; HostDB:ENSMUSG00000078815; -.
DR eggNOG; ENOG502QUPR; Eukaryota.
DR GeneTree; ENSGT00390000007786; -.
DR InParanoid; Q8VHW3; -.
DR OMA; KTLWVAD; -.
DR OrthoDB; 1226225at2759; -.
DR PhylomeDB; Q8VHW3; -.
DR TreeFam; TF331651; -.
DR Reactome; R-MMU-5576892; Phase 0 - rapid depolarisation.
DR Reactome; R-MMU-5576893; Phase 2 - plateau phase.
DR BioGRID-ORCS; 54378; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8VHW3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VHW3; protein.
DR Bgee; ENSMUSG00000078815; Expressed in quadriceps femoris and 39 other tissues.
DR ExpressionAtlas; Q8VHW3; baseline and differential.
DR Genevisible; Q8VHW3; MM.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008370; VDCC_g6su.
DR InterPro; IPR008368; VDCC_gsu.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01794; VDCCGAMMA6.
PE 1: Evidence at protein level;
KW Calcium; Calcium channel; Calcium transport; Cell membrane; Ion channel;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..260
FT /note="Voltage-dependent calcium channel gamma-6 subunit"
FT /id="PRO_0000164685"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 260 AA; 28145 MW; 583C326BE6D88C80 CRC64;
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE
FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF
TTGENARIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAESL LRLGAVCFGL
SGLLLFVSLE VFRHSVGALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL
LTLPSWPWRS LCPKWGGPTA
