CCG6_RAT
ID CCG6_RAT Reviewed; 260 AA.
AC Q8VHW7; Q8VHW6;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Voltage-dependent calcium channel gamma-6 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-6 subunit;
GN Name=Cacng6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND TISSUE
RP SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=11738816; DOI=10.1016/s0378-1119(01)00738-7;
RA Chu P.-J., Robertson H.M., Best P.M.;
RT "Calcium channel gamma subunits provide insights into the evolution of this
RT gene family.";
RL Gene 280:37-48(2001).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=21127204; DOI=10.1096/fj.10-172353;
RA Yang L., Katchman A., Morrow J.P., Doshi D., Marx S.O.;
RT "Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.";
RL FASEB J. 25:928-936(2011).
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit.
CC {ECO:0000250|UniProtKB:Q9BXT2}.
CC -!- SUBUNIT: Interacts with CACNA1C. Identified in a complex with the L-
CC type calcium channel subunits CACNA1C, CACNA2D1 and either CACNB1 or
CC CACNB2. {ECO:0000250|UniProtKB:Q9BXT2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXT2};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXT2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q8VHW7-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q8VHW7-2; Sequence=VSP_005074;
CC -!- TISSUE SPECIFICITY: Detected in heart atrium and ventricle, aorta and
CC skeletal muscle (PubMed:11738816). Detected in heart left ventricle
CC (PubMed:21127204). {ECO:0000269|PubMed:11738816,
CC ECO:0000269|PubMed:21127204}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; AF361343; AAL50038.1; -; mRNA.
DR EMBL; AF361344; AAL50039.1; -; mRNA.
DR RefSeq; NP_542425.1; NM_080694.1. [Q8VHW7-1]
DR RefSeq; XP_008756971.1; XM_008758749.1. [Q8VHW7-2]
DR AlphaFoldDB; Q8VHW7; -.
DR SMR; Q8VHW7; -.
DR STRING; 10116.ENSRNOP00000019211; -.
DR PaxDb; Q8VHW7; -.
DR PRIDE; Q8VHW7; -.
DR Ensembl; ENSRNOT00000106854; ENSRNOP00000092698; ENSRNOG00000063051. [Q8VHW7-2]
DR Ensembl; ENSRNOT00000111328; ENSRNOP00000095459; ENSRNOG00000063051. [Q8VHW7-1]
DR GeneID; 140727; -.
DR KEGG; rno:140727; -.
DR UCSC; RGD:628806; rat. [Q8VHW7-1]
DR CTD; 59285; -.
DR RGD; 628806; Cacng6.
DR eggNOG; ENOG502QUPR; Eukaryota.
DR GeneTree; ENSGT00390000007786; -.
DR HOGENOM; CLU_093876_0_0_1; -.
DR InParanoid; Q8VHW7; -.
DR OMA; KTLWVAD; -.
DR OrthoDB; 1226225at2759; -.
DR PhylomeDB; Q8VHW7; -.
DR TreeFam; TF331651; -.
DR Reactome; R-RNO-5576892; Phase 0 - rapid depolarisation.
DR Reactome; R-RNO-5576893; Phase 2 - plateau phase.
DR PRO; PR:Q8VHW7; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000057852; Expressed in skeletal muscle tissue and 8 other tissues.
DR Genevisible; Q8VHW7; RN.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008370; VDCC_g6su.
DR InterPro; IPR008368; VDCC_gsu.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01794; VDCCGAMMA6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Calcium channel; Calcium transport;
KW Cell membrane; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..260
FT /note="Voltage-dependent calcium channel gamma-6 subunit"
FT /id="PRO_0000164686"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 136..181
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:11738816"
FT /id="VSP_005074"
SQ SEQUENCE 260 AA; 28255 MW; DBE75E0F21C2BFC5 CRC64;
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE
FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF
TTGENAHIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAEFL LRLGAVCFGL
SGLLLFVSLE VFRHSVRALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL
LTLPSWPWRS LCPKRGGPTA